@parenpatel.bsky.social
NanoTemper | Biophysics enthusiast | Grandpa | 🥼 | Talks about #GPCR #Membrane Proteins #mAbs | ♫ | 🍺 | 🎱 | 🌶️ and 🏎️🏁
🧬 𝐊𝐑𝐀𝐒 𝐁𝐢𝐧𝐝𝐢𝐧𝐠: 𝐀 𝐒𝐭𝐞𝐩 𝐓𝐨𝐰𝐚𝐫𝐝 𝐒𝐦𝐚𝐫𝐭𝐞𝐫 𝐈𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬
Different KRAS mutations shape the accessibility of the #switch-II pocket—a key target for modern small-molecule inhibitors.
www.linkedin.com/posts/parenp...
Different KRAS mutations shape the accessibility of the #switch-II pocket—a key target for modern small-molecule inhibitors.
www.linkedin.com/posts/parenp...
June 20, 2025 at 7:15 PM
🧬 𝐊𝐑𝐀𝐒 𝐁𝐢𝐧𝐝𝐢𝐧𝐠: 𝐀 𝐒𝐭𝐞𝐩 𝐓𝐨𝐰𝐚𝐫𝐝 𝐒𝐦𝐚𝐫𝐭𝐞𝐫 𝐈𝐧𝐡𝐢𝐛𝐢𝐭𝐨𝐫𝐬
Different KRAS mutations shape the accessibility of the #switch-II pocket—a key target for modern small-molecule inhibitors.
www.linkedin.com/posts/parenp...
Different KRAS mutations shape the accessibility of the #switch-II pocket—a key target for modern small-molecule inhibitors.
www.linkedin.com/posts/parenp...
𝐈𝐃-𝐓𝐞𝐬𝐭𝐢𝐧𝐠 𝐁𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐬 𝐌𝐚𝐧𝐮𝐟𝐚𝐜𝐭𝐮𝐫𝐢𝐧𝐠 - 𝑭𝒊𝒍𝒍 & 𝑭𝒊𝒏𝒊𝒔𝒉
See how Dr Marius Müller (Johnson & Johnson Innovative Medicine) employs unfolding curves like a fingerprint to confirm product identity.
Sign up here---> lnkd.in/evyFxgSJ
More here tinyurl.com/yc5z5wmf
#Biomanufacturing #Formulation #Biologics
See how Dr Marius Müller (Johnson & Johnson Innovative Medicine) employs unfolding curves like a fingerprint to confirm product identity.
Sign up here---> lnkd.in/evyFxgSJ
More here tinyurl.com/yc5z5wmf
#Biomanufacturing #Formulation #Biologics
March 5, 2025 at 9:15 PM
𝐈𝐃-𝐓𝐞𝐬𝐭𝐢𝐧𝐠 𝐁𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐬 𝐌𝐚𝐧𝐮𝐟𝐚𝐜𝐭𝐮𝐫𝐢𝐧𝐠 - 𝑭𝒊𝒍𝒍 & 𝑭𝒊𝒏𝒊𝒔𝒉
See how Dr Marius Müller (Johnson & Johnson Innovative Medicine) employs unfolding curves like a fingerprint to confirm product identity.
Sign up here---> lnkd.in/evyFxgSJ
More here tinyurl.com/yc5z5wmf
#Biomanufacturing #Formulation #Biologics
See how Dr Marius Müller (Johnson & Johnson Innovative Medicine) employs unfolding curves like a fingerprint to confirm product identity.
Sign up here---> lnkd.in/evyFxgSJ
More here tinyurl.com/yc5z5wmf
#Biomanufacturing #Formulation #Biologics
Reposted
There's a new toy in the lab! I’ve been dreaming of acquiring a Prometheus for a long time (since my PhD), and we finally managed to purchase one at the #LaJollaInstitute. I can't wait to start characterizing our glycoproteins with it! #biophysics #cryoem #proteinfolding
November 17, 2024 at 6:52 AM
There's a new toy in the lab! I’ve been dreaming of acquiring a Prometheus for a long time (since my PhD), and we finally managed to purchase one at the #LaJollaInstitute. I can't wait to start characterizing our glycoproteins with it! #biophysics #cryoem #proteinfolding
Reposted
Just out: A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors
A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors
Communications Chemistry, Published online: 03 February 2025; doi:10.1038/s42004-025-01439-9RNA methyltransferases (MTases) are drug targets that catalyze RNA methylation, a reaction associated to disease, but medium and high-throughput screening assays…
bit.ly
February 4, 2025 at 3:13 AM
Just out: A microscale thermophoresis-based enzymatic RNA methyltransferase assay enables the discovery of DNMT2 inhibitors
Reposted
During revisions, we've added lots of exciting new data, so be sure to check out the paper! Most importantly, we now demonstrate that Elongator regulates polyglutamylation levels of spindle microtubules, both in cells and in vivo.
January 17, 2025 at 9:46 AM
During revisions, we've added lots of exciting new data, so be sure to check out the paper! Most importantly, we now demonstrate that Elongator regulates polyglutamylation levels of spindle microtubules, both in cells and in vivo.
Reposted
Nanotemper #Prometheus looks so cool 😎
November 19, 2024 at 11:08 PM
Nanotemper #Prometheus looks so cool 😎
Reposted
I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….
February 19, 2025 at 8:22 PM
I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….
𝐀 𝐍𝐞𝐰 𝐄𝐫𝐚 𝐢𝐧 𝐓𝐚𝐫𝐠𝐞𝐭𝐞𝐝 𝐏𝐫𝐨𝐭𝐞𝐢𝐧 𝐃𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧
𝐂𝐲𝐜𝐥𝐢𝐧 𝐊 - 𝑯𝒐𝒘 𝒂𝒏 𝒊𝒏𝒉𝒊𝒃𝒊𝒕𝒐𝒓 𝒘𝒂𝒔 𝒕𝒓𝒂𝒏𝒔𝒇𝒐𝒓𝒎𝒆𝒅 𝒊𝒏𝒕𝒐 𝒂 𝒎𝒐𝒍𝒆𝒄𝒖𝒍𝒂𝒓 𝒈𝒍𝒖𝒆
tinyurl.com/3khpakrs
𝐂𝐲𝐜𝐥𝐢𝐧 𝐊 - 𝑯𝒐𝒘 𝒂𝒏 𝒊𝒏𝒉𝒊𝒃𝒊𝒕𝒐𝒓 𝒘𝒂𝒔 𝒕𝒓𝒂𝒏𝒔𝒇𝒐𝒓𝒎𝒆𝒅 𝒊𝒏𝒕𝒐 𝒂 𝒎𝒐𝒍𝒆𝒄𝒖𝒍𝒂𝒓 𝒈𝒍𝒖𝒆
tinyurl.com/3khpakrs
February 19, 2025 at 4:59 PM
𝐀 𝐍𝐞𝐰 𝐄𝐫𝐚 𝐢𝐧 𝐓𝐚𝐫𝐠𝐞𝐭𝐞𝐝 𝐏𝐫𝐨𝐭𝐞𝐢𝐧 𝐃𝐞𝐠𝐫𝐚𝐝𝐚𝐭𝐢𝐨𝐧
𝐂𝐲𝐜𝐥𝐢𝐧 𝐊 - 𝑯𝒐𝒘 𝒂𝒏 𝒊𝒏𝒉𝒊𝒃𝒊𝒕𝒐𝒓 𝒘𝒂𝒔 𝒕𝒓𝒂𝒏𝒔𝒇𝒐𝒓𝒎𝒆𝒅 𝒊𝒏𝒕𝒐 𝒂 𝒎𝒐𝒍𝒆𝒄𝒖𝒍𝒂𝒓 𝒈𝒍𝒖𝒆
tinyurl.com/3khpakrs
𝐂𝐲𝐜𝐥𝐢𝐧 𝐊 - 𝑯𝒐𝒘 𝒂𝒏 𝒊𝒏𝒉𝒊𝒃𝒊𝒕𝒐𝒓 𝒘𝒂𝒔 𝒕𝒓𝒂𝒏𝒔𝒇𝒐𝒓𝒎𝒆𝒅 𝒊𝒏𝒕𝒐 𝒂 𝒎𝒐𝒍𝒆𝒄𝒖𝒍𝒂𝒓 𝒈𝒍𝒖𝒆
tinyurl.com/3khpakrs