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Paola GAruffo
@paolagaruffo.bsky.social
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PhD candidate @Joyce lab | Brain Tumor Microenvironment | Immunsuppression | @joycelab.bsky.social
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Reposted by Paola GAruffo
johannajoyce.bsky.social
And if you're interested to read more 🤔 - here are some news perspectives from @ludwigcancer.bsky.social and @unil.bsky.social 🧪🧠

www.unil.ch/news/1742984...

www.ludwigcancerresearch.org/news-release...
Why breast-to-brain metastases resist immunotherapy and radiation
Why do breast cancer metastases resist treatment in the brain? A new Cell Reports study by Prof. Joyce and Dr. Wischnewski uncovers how the brain’s tumor environment suppresses immune responses, block...
www.unil.ch
March 31, 2025 at 12:26 PM
Reposted by Paola GAruffo
fbm-unil.bsky.social
🧬 Why do #breast-to-brain #metastases resist treatment?
This study in @cp-cellreports.bsky.social shows how the brain's tumor environment suppresses immune responses and impairs therapy.

🔗 Original paper: www.cell.com/cell-reports...
The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis
Wischnewski et al. demonstrate suppressed CD8+ T cell cytotoxicity in breast cancer brain metastases, contrasting with genetically identical extracranial tumors. Neutrophils and Trem2+ macrophages dri...
www.cell.com
March 27, 2025 at 9:34 AM