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paolagaruffo.bsky.social
Paola GAruffo
@paolagaruffo.bsky.social
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PhD candidate @Joyce lab | Brain Tumor Microenvironment | Immunsuppression | @joycelab.bsky.social
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Reposted by Paola GAruffo
johannajoyce.bsky.social
Celebrating our annual international lab dinner 🎉 👨🏽‍🍳 🧑🏻‍🍳

We are so fortunate to have this amazing team of motivated scientists, and very talented cooks 🤩 sharing delicious food & culture from around the world 🌍🌎🌏

Grateful for our #international #team 🇮🇹🇫🇷🇨🇦🇪🇸🇨🇭🇬🇧🇪🇬🇩🇪🇵🇹🇲🇽🇮🇪 - this truly enriches our science 🙏 🙌
Photo of all our team members at our international lab dinner, with some of the dishes at the front of the picture
September 25, 2025 at 1:46 PM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Dear friends at the University of Lausanne - please consider signing this petition

This is to say NO to the funding cut of 24 million CHF that will negatively impact the quality of our teaching & research 🧪🧑🏼‍🎓 - and have a knock-on effect on the local economy

All students, staff, faculty can sign ⏬
Let’s reject budget cuts in education and research!
We, researchers, students, and members of the administrative and technical staff of the University of Lausanne (UNIL), firmly oppose the budget cuts announced for UNIL by the government of Vaud on 24t...
vaud.ssp-vpod.ch
September 12, 2025 at 1:58 PM
Reposted by Paola GAruffo
helloeacr.bsky.social
A record 1732 posters are being presented at #EACR2025, covering a wide range of cancer research topics. The abstracts and e-Posters are online for anyone to browse: 2025.eacr.org/abstracts
June 18, 2025 at 8:53 AM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Wishing our amazing postdoc @lbejarano.bsky.social continued success and happiness - as she leaves us to start her own lab in Spain 🎉🥳

Leire has been one of the most positive, creative, and kind scientists I've had the privilege to mentor - we shall all miss you so much!

#NewPI 🤩
#ProudMentor 😊
May 27, 2025 at 6:07 PM
Reposted by Paola GAruffo
klangin.bsky.social
"The lived experience of a scientist right now is terrifying."

Story by @science.org's Warren Cornwall—about the fear of retaliation permeating the scientific community.

www.science.org/content/arti...
Trump’s ‘fear factor’: Scientists go silent as funding cuts escalate
Many worry about retribution. But for others, speaking out is worth the risk
www.science.org
May 13, 2025 at 4:42 PM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Thanks to "The Scientist" for this great article covering a recent study from our lab where we explored why breast-to-brain metastases resist #immunotherapy — even when the same cancer type responds outside the brain.. 🧠🧪🔬

#brain #cancer #metastasis

www.the-scientist.com/why-are-brea...
Why Are Breast Cancers That Metastasize to the Brain Hard to Treat?
Immunosuppressive factors prevent killer T cells from defeating brain tumors that arise from primary breast cancer.
www.the-scientist.com
May 16, 2025 at 11:12 AM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Not long after I started my lab, a prominent scientist told me it was “impossible” to be a successful PI and a mother

Don’t ever let the naysayers tell you it can’t be done - of course it can!

#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
May 9, 2025 at 6:23 PM
Reposted by Paola GAruffo
science.org
President Donald Trump today asked Congress to make massive and unprecedented cuts to the 2026 budgets of major federal science agencies. scim.ag/3Yszqnm
Trump’s proposed budget would mean ‘disastrous’ cuts to science
Key research budgets would shrink by one-third to one-half in 2026 spending plan
scim.ag
May 2, 2025 at 10:06 PM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Excited to see our image on the cover of #Immunity today 🤩

Congrats to the amazing @lbejarano.bsky.social & all authors for our #brain #tumor #vasculature study

www.cell.com/immunity/ful...

Huge 🙏 🙏 to the v talented @joanagcc.bsky.social for creating this super cover 🧠🧪

@cp-immunity.bsky.social
On the cover: The blood-brain barrier is a defining feature of brain tumors, shaping their biology and therapeutic response. In this issue, Bejarano et al. use single-cell RNA sequencing and spatial analysis to construct a vascular atlas of primary and metastatic brain tumors, revealing distinct alterations in endothelial and mural cells. Glioblastomas undergo substantial vascular remodeling compared to low-grade gliomas, while brain metastases exhibit even greater permeability and increased immune cell interactions. This unveiling of vascular heterogeneity is depicted as a red pencil coloring in the intricate details of tumor-associated blood vessels within a map of the human brain wherein a tumor is surrounded by diverse immune cells. Image by Joana C. Carvalho.
April 8, 2025 at 2:50 PM
Reposted by Paola GAruffo
johannajoyce.bsky.social
And if you're interested to read more 🤔 - here are some news perspectives from @ludwigcancer.bsky.social and @unil.bsky.social 🧪🧠

www.unil.ch/news/1742984...

www.ludwigcancerresearch.org/news-release...
Why breast-to-brain metastases resist immunotherapy and radiation
Why do breast cancer metastases resist treatment in the brain? A new Cell Reports study by Prof. Joyce and Dr. Wischnewski uncovers how the brain’s tumor environment suppresses immune responses, block...
www.unil.ch
March 31, 2025 at 12:26 PM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Why do brain metastases resist #immunotherapy — even when the same cancer responds outside the #brain? 🧠🧪💥

We just published a study diving into this question ⏬

Led by an amazing (former) PhD student in my lab —Vladimir Wischnewski 🎉

🧵 1/

@cp-cellreports.bsky.social

www.cell.com/cell-reports...
March 31, 2025 at 12:20 PM
Reposted by Paola GAruffo
ludwigcancer.bsky.social
Study led by Ludwig @fbm-unil.bsky.social’s @johannajoyce.bsky.social and alumnus Vladimir Wischnewski explains why brain metastases of breast cancer are likely to resist potentially synergistic combinations of radiotherapy and checkpoint blockade #immunotherapy. Learn more: bit.ly/4kZTKGo

#CanSky
March 24, 2025 at 3:56 PM
Reposted by Paola GAruffo
fbm-unil.bsky.social
🧬 Why do #breast-to-brain #metastases resist treatment?
This study in @cp-cellreports.bsky.social shows how the brain's tumor environment suppresses immune responses and impairs therapy.

🔗 Original paper: www.cell.com/cell-reports...
The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis
Wischnewski et al. demonstrate suppressed CD8+ T cell cytotoxicity in breast cancer brain metastases, contrasting with genetically identical extracranial tumors. Neutrophils and Trem2+ macrophages dri...
www.cell.com
March 27, 2025 at 9:34 AM
Reposted by Paola GAruffo
fbm-unil.bsky.social
🧠 Pourquoi les #métastases #cérébrales du cancer du #sein résistent-elles aux traitements?
Une étude de @joycelab.bsky.social révèle que l’environnement tumoral cérébral bloque l’action des cellules immunitaires.

🔗 News: www.unil.ch/news/1742984...
Why breast-to-brain metastases resist immunotherapy and radiation
Why do breast cancer metastases resist treatment in the brain? A new Cell Reports study by Prof. Joyce and Dr. Wischnewski uncovers how the brain’s tumor environment suppresses immune responses, block...
www.unil.ch
March 27, 2025 at 9:34 AM
Reposted by Paola GAruffo
johannajoyce.bsky.social
How does the #vasculature regulate #immune cell infiltration & function across different brain tumors? 🧠🧪

Excited to share our latest study in #Immunity where we uncover some interesting answers— led by the amazing @lbejarano.bsky.social 🤩👏🏻

🧵

@cp-immunity.bsky.social

www.cell.com/immunity/ful...
March 20, 2025 at 1:51 PM
Reposted by Paola GAruffo
lbejarano.bsky.social
Thrilled to see our vascular atlas across primary and metastatic brain tumors finally out in Immunity! 😍 🍾

Thanks to @johannajoyce.bsky.social for her invaluable mentorship and to all the authors involved! 🎉
March 20, 2025 at 10:12 AM
Reposted by Paola GAruffo
ludwigcancer.bsky.social
Researchers led by Ludwig @fbm-unil.bsky.social’s
@lbejarano.bsky.social & @johannajoyce.bsky.social analyzed individual cells of the blood-brain barrier across brain tissue, primary brain tumors & brain metastases, creating a vascular atlas to guide the design of new therapies.

bit.ly/4bFqwYY
March 19, 2025 at 6:19 PM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Well done to the first recipients of the EACR-Mark Foundation postdoc fellowships 🎉🎊

And a happy coincidence that all three awardees are women scientists in the labs of three women PIs 🙌

#WomeninSTEM #WomeninScience 👩‍🔬👩🏻‍🔬🧪

@themarkfdn.bsky.social
@helloeacr.bsky.social
@juliemmazet.bsky.social
helloeacr.bsky.social EACR - European Association for Cancer Research @helloeacr.bsky.social · Mar 19
Congratulations to our first EACR-@themarkfdn Postdoctoral Fellowship winners! Julie Mazet, Christina Metoikidou and Martha Zarou 👏

This funding is awarded for a period of three years to support excellent postdoctoral researchers in laboratories throughout Europe.

magazine.eacr.org/congratulati...
March 19, 2025 at 10:33 AM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Cancer knows no borders, and setbacks in one part of the world can have lasting consequences for #patients everywhere

The #EACR, and all co-signing national #cancer societies & foundations, stand in solidarity and offer our full support to our friends and colleagues in the US

#StandUpForScience 🧪
March 10, 2025 at 12:06 PM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Now, more than ever, the #global #science community needs to stand together - #united against those who attack science 🧪, who seek to diminish #scientists, who destroy critical programs that advance #equality, #diversity and #inclusion

Please consider to join us in signing the #MilanDeclaration ⏬
March 5, 2025 at 11:52 AM
Reposted by Paola GAruffo
science.org
Rodent and monkey facilities could be imperiled by the Trump administration’s plan to slash overhead costs that the National Institutes of Health pays to institutions for medical research. scim.ag/3QvS4GC
‘Death by ax.’ Fate of millions of research animals at stake in NIH payments lawsuit
Rodent and monkey facilities imperiled by Trump plan to cut overhead payments
scim.ag
February 21, 2025 at 3:29 PM
Reposted by Paola GAruffo
vjrp.bsky.social
In my latest article for @science.org, I reflect on the current challenges faced by early-career researchers, including delays in grant reviews, uncertainty around NIH funding freezes and changes, and the critical need for continued support and advocacy.
www.science.org/content/arti...
I’m an NIH-funded researcher, drowning in uncertainty
“I’ll keep doing what I can to move my research forward. But I, and so many others, can’t do this indefinitely,” this assistant professor writes
www.science.org
February 21, 2025 at 6:58 PM
Reposted by Paola GAruffo
martin-jk.bsky.social
Die Rektoratsmitglieder der Uni Heidelberg begrüßen die von Wissenschaftlerinnen und Wissenschaftlern bundesweit getragene Initiative, die unter der Überschrift „Demokratie braucht Fakten“ zur Wahl demokratischer Parteien aufruft.
www.uni-heidelberg.de/de/bei-der-b...

#aufstehenfuerdemokratie
Bei der Bundestagswahl am 23. Februar vom Wahlrecht Gebrauch machen - Universität Heidelberg
Das Rektorat der Universität Heidelberg schließt sich einem gemeinsamen Aufruf der Hochschulrektorenkonferenz (HRK), des Deutschen Studierendenwerks (DSW) und
www.uni-heidelberg.de
February 10, 2025 at 4:33 PM
Reposted by Paola GAruffo
winklerlab.bsky.social
#aufstehenfuerdemokratie

Um 11:55 Uhr versammelte sich eine große Gruppe von Wissenschaftlern & Unterstützern, um ein Statement für faktenbasierte Entscheidungen und Demokratie abzugeben:

Geht wahlen-mit Verstand!

Inspirierende Worte von Prof. E. Winkler und Prof. S. Pfister -
Danke an Alle!
February 12, 2025 at 11:22 AM
Reposted by Paola GAruffo
johannajoyce.bsky.social
Happy International Day of Women and Girls in Science!

Its been a privilege to work with these extraordinary scientists in my lab over the years - all making an incredible impact throughout the world 🙌

We must never give up on #equality #diversity & #inclusion 💪

#WomeninScience #GirlsInSTEM 🧪🔬🔭🚀
Composite image of women scientists from the Joyce lab over the past 20 years
February 11, 2025 at 12:01 PM