Organic Chemistry Portal
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Cerium chloride efficiently catalyses the ring opening of epoxides with aromatic amines to generate β-amino alcohols.
Cerium chloride efficiently catalyses the ring opening of epoxides with aromatic amines to generate β-amino alcohols.
November 24, 2025 at 11:43 AM
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Cerium chloride efficiently catalyses the ring opening of epoxides with aromatic amines to generate β-amino alcohols.
Cerium chloride efficiently catalyses the ring opening of epoxides with aromatic amines to generate β-amino alcohols.
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An N-heterocyclic carbene catalyzes a radical-mediated sulfonyl methylation of readily available aldehydes to provide α-sulfonyl ketones.
An N-heterocyclic carbene catalyzes a radical-mediated sulfonyl methylation of readily available aldehydes to provide α-sulfonyl ketones.
November 24, 2025 at 11:40 AM
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An N-heterocyclic carbene catalyzes a radical-mediated sulfonyl methylation of readily available aldehydes to provide α-sulfonyl ketones.
An N-heterocyclic carbene catalyzes a radical-mediated sulfonyl methylation of readily available aldehydes to provide α-sulfonyl ketones.
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The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes
The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes
November 24, 2025 at 11:37 AM
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The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes
The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes
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Oxidation of anthranilamides, salicylamides and some β-substituted amides with iodobenzene diacetate in methanolic potassium hydroxide
Oxidation of anthranilamides, salicylamides and some β-substituted amides with iodobenzene diacetate in methanolic potassium hydroxide
November 24, 2025 at 11:34 AM
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Oxidation of anthranilamides, salicylamides and some β-substituted amides with iodobenzene diacetate in methanolic potassium hydroxide
Oxidation of anthranilamides, salicylamides and some β-substituted amides with iodobenzene diacetate in methanolic potassium hydroxide
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Mechanochemically activated magnesium(0) metal is a highly active mediator for the direct C-4-H alkylation of pyridines with alkyl halides.
Mechanochemically activated magnesium(0) metal is a highly active mediator for the direct C-4-H alkylation of pyridines with alkyl halides.
November 24, 2025 at 11:31 AM
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Mechanochemically activated magnesium(0) metal is a highly active mediator for the direct C-4-H alkylation of pyridines with alkyl halides.
Mechanochemically activated magnesium(0) metal is a highly active mediator for the direct C-4-H alkylation of pyridines with alkyl halides.
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Trifluoromethyl thianthrenium triflate is a conveniently accessible trifluoromethylating reagent
Trifluoromethyl thianthrenium triflate is a conveniently accessible trifluoromethylating reagent
November 24, 2025 at 11:29 AM
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Trifluoromethyl thianthrenium triflate is a conveniently accessible trifluoromethylating reagent
Trifluoromethyl thianthrenium triflate is a conveniently accessible trifluoromethylating reagent
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Douglass features Carbon-Carbon Bond Formation: The Renata Synthesis of Lycoposerramine W
Douglass features Carbon-Carbon Bond Formation: The Renata Synthesis of Lycoposerramine W
November 23, 2025 at 5:40 PM
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Douglass features Carbon-Carbon Bond Formation: The Renata Synthesis of Lycoposerramine W
Douglass features Carbon-Carbon Bond Formation: The Renata Synthesis of Lycoposerramine W
Molecule of the week: Lycoposerramine W
Lycopodium alkaloids are attractive synthetic targets due to their diverse and unusual skeletal features. While numerous synthetic approaches have been reported, outstanding synthetic challenges remain.
More Info: www.organic-chemistry.org/Highlights/2...
Lycopodium alkaloids are attractive synthetic targets due to their diverse and unusual skeletal features. While numerous synthetic approaches have been reported, outstanding synthetic challenges remain.
More Info: www.organic-chemistry.org/Highlights/2...
November 23, 2025 at 5:30 PM
Molecule of the week: Lycoposerramine W
Lycopodium alkaloids are attractive synthetic targets due to their diverse and unusual skeletal features. While numerous synthetic approaches have been reported, outstanding synthetic challenges remain.
More Info: www.organic-chemistry.org/Highlights/2...
Lycopodium alkaloids are attractive synthetic targets due to their diverse and unusual skeletal features. While numerous synthetic approaches have been reported, outstanding synthetic challenges remain.
More Info: www.organic-chemistry.org/Highlights/2...
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Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF
Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF
November 21, 2025 at 12:58 PM
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Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF
Indium mediated reduction of azide and nitro groups in the presence of HCl (1.5 equiv based on indium) at room temperature in aqueous THF
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An unprecedented metal-free reaction of o-aminobenzamides with CO2 provides N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones
An unprecedented metal-free reaction of o-aminobenzamides with CO2 provides N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones
November 21, 2025 at 12:56 PM
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An unprecedented metal-free reaction of o-aminobenzamides with CO2 provides N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones
An unprecedented metal-free reaction of o-aminobenzamides with CO2 provides N-unsubstituted and N3-substituted quinazoline-2,4(1H,3H)-diones
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A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source
A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source
November 21, 2025 at 12:54 PM
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A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source
A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source
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A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates
A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates
November 21, 2025 at 12:51 PM
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A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates
A mild and convenient method for the preparation of amides from carboxylic acids and isocyanates
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A practical and efficient photoinduced decarboxylative/dehydrogenative coupling of α-fluoroacrylic acids with phosphine oxides
A practical and efficient photoinduced decarboxylative/dehydrogenative coupling of α-fluoroacrylic acids with phosphine oxides
November 21, 2025 at 12:48 PM
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A practical and efficient photoinduced decarboxylative/dehydrogenative coupling of α-fluoroacrylic acids with phosphine oxides
A practical and efficient photoinduced decarboxylative/dehydrogenative coupling of α-fluoroacrylic acids with phosphine oxides
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Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides
Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides
November 21, 2025 at 12:00 PM
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Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides
Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides
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A Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides
A Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides
November 21, 2025 at 11:58 AM
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A Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides
A Gold(I)-catalyzed hetero-tetradehydro-Diels-Alder cycloaddition of enynamides and cyanamides
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A convenient Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols
A convenient Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols
November 21, 2025 at 11:55 AM
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A convenient Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols
A convenient Ni-catalyzed cross-coupling of inactivated or β-aryl-substituted (E)-alkenyl halides with thio-alcohols/phenols
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A chloroaluminate ionic liquid can be used as a solvent as well as a catalyst for the The Fischer indole synthesis.
A chloroaluminate ionic liquid can be used as a solvent as well as a catalyst for the The Fischer indole synthesis.
November 21, 2025 at 11:53 AM
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A chloroaluminate ionic liquid can be used as a solvent as well as a catalyst for the The Fischer indole synthesis.
A chloroaluminate ionic liquid can be used as a solvent as well as a catalyst for the The Fischer indole synthesis.
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November 21, 2025 at 11:33 AM
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November 20, 2025 at 5:59 PM
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November 20, 2025 at 3:52 PM
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Metalated ketimines are converted into enaminones in good to excellent yields in the presence of acylbenzotriazoles.
Metalated ketimines are converted into enaminones in good to excellent yields in the presence of acylbenzotriazoles.
November 20, 2025 at 11:30 AM
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Metalated ketimines are converted into enaminones in good to excellent yields in the presence of acylbenzotriazoles.
Metalated ketimines are converted into enaminones in good to excellent yields in the presence of acylbenzotriazoles.
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N-Bromosuccinimide mediates a tandem oxidative/nucleophilic substitution approach for the synthesis of sulfinamidines
N-Bromosuccinimide mediates a tandem oxidative/nucleophilic substitution approach for the synthesis of sulfinamidines
November 20, 2025 at 11:27 AM
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N-Bromosuccinimide mediates a tandem oxidative/nucleophilic substitution approach for the synthesis of sulfinamidines
N-Bromosuccinimide mediates a tandem oxidative/nucleophilic substitution approach for the synthesis of sulfinamidines
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Depending on the Lewis base catalyst, a Michael addition of α-aminonitriles to simple activated alkenes provides functionalized γ-amino acid esters or γ-lactams.
Depending on the Lewis base catalyst, a Michael addition of α-aminonitriles to simple activated alkenes provides functionalized γ-amino acid esters or γ-lactams.
November 20, 2025 at 11:24 AM
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Depending on the Lewis base catalyst, a Michael addition of α-aminonitriles to simple activated alkenes provides functionalized γ-amino acid esters or γ-lactams.
Depending on the Lewis base catalyst, a Michael addition of α-aminonitriles to simple activated alkenes provides functionalized γ-amino acid esters or γ-lactams.
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A convenient 1,3-dipolar cycloaddition of pyridinium N-methylides - in situ generated from the corresponding N-(carboxymethyl)pyridinium halides
A convenient 1,3-dipolar cycloaddition of pyridinium N-methylides - in situ generated from the corresponding N-(carboxymethyl)pyridinium halides
November 20, 2025 at 11:21 AM
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A convenient 1,3-dipolar cycloaddition of pyridinium N-methylides - in situ generated from the corresponding N-(carboxymethyl)pyridinium halides
A convenient 1,3-dipolar cycloaddition of pyridinium N-methylides - in situ generated from the corresponding N-(carboxymethyl)pyridinium halides
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Synthesis of 3-substituted tetrahydropyridines with high enantioselectivity
Synthesis of 3-substituted tetrahydropyridines with high enantioselectivity
November 20, 2025 at 11:19 AM
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Synthesis of 3-substituted tetrahydropyridines with high enantioselectivity
Synthesis of 3-substituted tetrahydropyridines with high enantioselectivity