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Communications regarding original articles and editorial management should be addressed to Kristina Tarczy-Hornoch, MD, DPhil, Editor in Chief, Journal of AAPOS. Information for authors appears at www.jaapos.org. Authors should consult these instructions before submitting manuscripts to this Journal.

The content on this site is intended for healthcare professionals. All content on this site: Copyright © 2025 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. The content on this site is intended for healthcare professionals. All content on this site: Copyright © 2025 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. Communication Communications regarding original articles and editorial management should be addressed to Kristina Tarczy-Hornoch, MD, DPhil, Editor in Chief, Journal of AAPOS. Information for authors appears at www.jaapos.org. Authors should consult these instructions before submitting manuscripts to this Journal. Contact Advertising Sales Service at 212-633-3648, for all advertising communications. Address business communications to Periodical Publisher, Elsevier Inc., 230 Park Avenue, Suite 800, New York, NY 10169. Visit our Web site at www.jaapos.org. Subscriptions Subscriptions may begin at any time. To enter a subscription to Journal of AAPOS (American Association for Pediatric Ophthalmology and Strabismus) visit https://www.jaapos.org/action/ecommerce or call 1-800-654-2452 or 1-314-447-8871 (outside the USA); fax 1-314-447-8029. Remittances made by check, draft, post office, or express money order should be in US funds, drawn through a US bank, made payable to this Journal, and sent to Elsevier Inc., Subscription Customer Service. Additional Services Indexed or abstracted in Index Medicus and MEDLINE. Commercial reprint inquiries should be addressed to Commercial Reprints Department, Elsevier Inc., 230 Park Avenue, Suite 800, New York, NY 10169; Email: reprints@elsevier.com. Orders, claims, and journal inquiries: Please visit our Support Hub page https://service.elsevier.com for assistance. Microform edition available from ProQuest Information and Learning, 300 N Zeeb Rd, Ann Arbor, MI 48106-1346. This Journal has been registered with Copyright Clearance Center, Inc, 222 Rosewood Dr, Danvers, MA 01923. Consent is given for the copying of articles for personal or internal use of specific clients. This consent is given on the condition that the copier pay directly to the center the per-copy fee stated on the first page of each article for copying beyond that permitted by US Copyright Law. This consent does not extend to other kinds of copying, such as for general distribution, resale, advertising, and promotional purposes, or for creating new collective works. All inquiries regarding copyrighted material from this publication, other than those that can be handled through the Center, should be directed, in writing (include complete citation, number of copies, and use), to Journals Permission Department, Elsevier, Journal Returns, 1799 Highway 50 East, Linn, MO 65051. All rights are reserved, including those for text and data mining, AI training, and similar technologies. No part of this publication may be reproduced, stored, or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher.

Enhanced premium tax credits, which have made Affordable Care Act coverage more accessible, will likely expire at the end of this year, which could lead to skyrocketing health care costs for many Americans. Dueling health care bills failed in the Senate today. Senators rejected both a bill to extend the tax credits for 3 years and an alternate plan that would have created new health savings accounts for consumers to put toward out-of-pocket costs, according to the Associated Press. The AP noted the arguments against each: some said the Democrat-backed extension legislation is too expensive and

Enhanced premium tax credits, which have made Affordable Care Act coverage more accessible, will likely expire at the end of this year, which could lead to skyrocketing health care costs for many Americans. Dueling health care bills failed in the Senate today. Senators rejected both a bill to extend the tax credits for 3 years and an alternate plan that would have created new health savings accounts for consumers to put toward out-of-pocket costs, according to the Associated Press. The AP noted the arguments against each: some said the Democrat-backed extension legislation is too expensive and

Even before she became a physician, Cathleen M. McCabe, MD, knew she wanted to help people across the world. Growing up in New Hampshire, McCabe did not travel much, but her parents hosted people from more than 40 countries through a local program, including students who would live with them for a year. “I had this idea, even as a kid, that I wanted to be able to do something impactful and make a difference,” she said. “I wanted to do that all over the world in places that didn’t have access to the kinds of things we had in the U.S.” Before medical school, McCabe started going on trips abroad to

Even before she became a physician, Cathleen M. McCabe, MD, knew she wanted to help people across the world. Growing up in New Hampshire, McCabe did not travel much, but her parents hosted people from more than 40 countries through a local program, including students who would live with them for a year. “I had this idea, even as a kid, that I wanted to be able to do something impactful and make a difference,” she said. “I wanted to do that all over the world in places that didn’t have access to the kinds of things we had in the U.S.” Before medical school, McCabe started going on trips abroad to

GLP-1 receptor agonists are not associated with increased risks for dry age-related macular degeneration or cataract development, according to two recently published studies. The data instead showed significantly reduced risk for cataracts, as well as lower risk for dry AMD, linked with the use of GLP-1s, according to Abhimanyu Ahuja, MD, an ophthalmology resident at the Oregon Health & Science University Casey Eye Institute, and colleagues. “Other studies have demonstrated that these medications have anti-inflammatory and neuroprotective properties,” Ahuja told Healio. “We

GLP-1 receptor agonists are not associated with increased risks for dry age-related macular degeneration or cataract development, according to two recently published studies. The data instead showed significantly reduced risk for cataracts, as well as lower risk for dry AMD, linked with the use of GLP-1s, according to Abhimanyu Ahuja, MD, an ophthalmology resident at the Oregon Health & Science University Casey Eye Institute, and colleagues. “Other studies have demonstrated that these medications have anti-inflammatory and neuroprotective properties,” Ahuja told Healio. “We

“Deepfake doctors” present a threat to patient trust, medicine’s most valuable currency, and regulations must be implemented to protect public health, according to an expert. At its Interim Meeting of the House of Delegates in November, the AMA adopted a policy to expand AI training across the medical education continuum and approved a resolution to create safeguards to protect both physicians and patients from deepfake technology “in the face of what supporters say is a ‘regulatory void,’” according to an AMA press release. Deepfake impersonators of physicians boast millions of views on social

“Deepfake doctors” present a threat to patient trust, medicine’s most valuable currency, and regulations must be implemented to protect public health, according to an expert. At its Interim Meeting of the House of Delegates in November, the AMA adopted a policy to expand AI training across the medical education continuum and approved a resolution to create safeguards to protect both physicians and patients from deepfake technology “in the face of what supporters say is a ‘regulatory void,’” according to an AMA press release. Deepfake impersonators of physicians boast millions of views on social

Eye, Published online: 11 December 2025; doi:10.1038/s41433-025-04158-6Primary uveal lymphoma mimicking uveitis with hypopyon

Eye, Published online: 11 December 2025; doi:10.1038/s41433-025-04159-5Forgotten but not gone: late extrusion of a MIRAgel scleral buckle decades after surgery

Eye, Published online: 10 December 2025; doi:10.1038/s41433-025-04167-5Aflibercept vs ranibizumab biosimilars: manufacturing differences that might matter in the long run

ORLANDO — In this video from the American Academy of Ophthalmology meeting, Michael W. Stewart, MD, discussed results from the phase 2 DAVIO 2 trial on Duravyu in neovascular age-related macular degeneration. Stewart, professor and chairman of ophthalmology at the Mayo Clinic, said that researchers found that patients who received Duravyu (vorolanib intravitreal insert, EyePoint Pharmaceuticals) “had very good, stable visual acuity over the course of 2 years as well as stable retinal morphology, which was noninferior to the aflibercept 2 mg control group.” He added that the results “highlight

A 40-year-old man was referred for bilateral macular degeneration detected on routine examination. His best-corrected visual acuity was 20/20 bilaterally without visual complaints. A, Color fundus photography showed no crystalline deposits, but hyperreflective spots were visible on red-free images. B, OCT demonstrated shallow irregular retinal pigment epithelium (RPE) elevations nasal to the macula. C, At 5-year follow-up, the hyperreflective spots had increased on red-free images, and OCT revealed interdigitation zone/ellipsoid zone disruption and patchy loss with reduction of the inner nuclear layer and increased RPE–Bruch’s membrane hyperreflectivity.

ORLANDO — In this Healio Video Perspective from the American Academy of Ophthalmology meeting, Jai G. Parekh, MD, MBA, discusses the benefits of the Lumenis Digital Duet 2.0 selective laser trabeculoplasty-YAG platform. “This has, by leaps and bounds, made some great changes,” he told Healio. “It has a great, iPad-looking interface that allows you to see exactly what you’re doing, not just for students fellows and residents that we train, but also for staff, family and even the patient.” {{VIDEO}} Parekh said the platform has been a big “game-changer” in terms of its interface, as well as the

ORLANDO — In this Healio Video Perspective from the American Academy of Ophthalmology meeting, Jai G. Parekh, MD, MBA, discusses the benefits of the Lumenis Digital Duet 2.0 selective laser trabeculoplasty-YAG platform. “This has, by leaps and bounds, made some great changes,” he told Healio. “It has a great, iPad-looking interface that allows you to see exactly what you’re doing, not just for students fellows and residents that we train, but also for staff, family and even the patient.” {{VIDEO}} Parekh said the platform has been a big “game-changer” in terms of its interface, as well as the

To determine current perioperative practice patterns for the prevention of endophthalmitis following cataract surgery in Thailand.

Background/aims To assess binocular visual performance, visual acuity at different contrast levels and visual disturbances in patients with primary open-angle glaucoma (POAG) undergoing bilateral cataract surgery with the placement of wavefront-shaping partial-range of field–extend (PROF-Ex) intraocular lens (IOL).Design Prospective, descriptive, single-arm study with 3 months of follow-up.Methods Patients diagnosed with bilateral early-to-moderate POAG were included and underwent cataract surgery with implantation of a PROF-Ex IOL (AcrySof IQ Vivity, Alcon Healthcare) bilaterally. Postoperative outcomes were measured in binocular conditions for visual acuity (uncorrected and corrected at varying distances and contrast levels), contrast sensitivity and visual disturbances assessed through light distortion analysis in terms of the light distortion index (LDI) and best-fit circle radius.Results 27 patients were included, with a mean age of 74.2±8.1 years. Three months after surgery, binocular corrected visual acuities at 100% contrast were –0.01±0.06, 0.11±0.08 and 0.26±0.13 LogMAR for far, intermediate and near distance vision, respectively. Those at 25% contrast were 0.57±0.11 and 0.65±0.12 LogMAR for intermediate and near distance vision, respectively. The mean binocular contrast sensitivity was 1.63±0.11, and the mean LDI was 13.28±7.06. No significant adverse events were recorded.Conclusions The wavefront-shaping PROF-Ex IOL technology shows positive outcomes in terms of visual acuity, contrast sensitivity and visual disturbances for patients with bilateral early-to-moderate POAG. Thus, wavefront-shaping PROF-Ex technology lenses can be a viable and effective option for patients with POAG seeking spectacle independence.

Aims To investigate corneal higher order aberrations (HOAs), densitometry and whole-eye optical quality after ultrathin Descemet’s stripping automated endothelial keratoplasty (UT-DSAEK), Descemet’s membrane endothelial keratoplasty (DMEK) and cataract surgery and the association with visual function.Methods This predefined secondary analysis of a randomised trial included 72 patients with Fuchs’ endothelial dystrophy (FED) and cataract for UT-DSAEK or DMEK combined with cataract surgery. Thirty-seven patients with cataract and healthy corneas served as controls and underwent cataract surgery alone.Results Total posterior HOAs were significantly higher 12 months after UT-DSAEK than DMEK (p

To identify areas in the US with high unmet need for ocular oncologists based on the geographic distribution of ocular oncologists and population density.

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Central serous chorioretinopathy (CSCR) is typically characterized by the presence of serous retinal detachment, resulting in visual impairment secondary to photoreceptor damage over time. 1 CSCR is ranked fourth most common among vision-threatening retinal diseases, preceded only by neovascular age-related macular degeneration, diabetic macular edema and central retinal vein occlusion. 2 CSCR has been shown to have male predominance, with 72-88% of affected patients being male.3 Acute forms of CSCR often represent a benign form of disease with a self-limiting course, typified by fluid resolution within 3 months.

The content on this site is intended for healthcare professionals. All content on this site: Copyright © 2025 Elsevier Inc., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.