In a phase 3 trial, Axpaxli, a tyrosine kinase inhibitor, achieved its superiority primary endpoint vs. aflibercept for the treatment of wet age-related macular degeneration, according to a press release from Ocular Therapeutix. “Despite advances in [neovascular age-related macular degeneration] treatment, there remains unpredictability around patient response to treatment, resulting in unsustainable burden and lack of adherence,” Pravin U. Dugel, MD, executive chairman, president and CEO of Ocular Therapeutix, told Healio. “In addition, fluid fluctuations and increased fibrosis lead to poor

In a phase 3 trial, Axpaxli, a tyrosine kinase inhibitor, achieved its superiority primary endpoint vs. aflibercept for the treatment of wet age-related macular degeneration, according to a press release from Ocular Therapeutix. “Despite advances in [neovascular age-related macular degeneration] treatment, there remains unpredictability around patient response to treatment, resulting in unsustainable burden and lack of adherence,” Pravin U. Dugel, MD, executive chairman, president and CEO of Ocular Therapeutix, told Healio. “In addition, fluid fluctuations and increased fibrosis lead to poor

Patients who have financial hardships have a significantly higher likelihood of experiencing moderate or severe cancer-related pain than those who do not. A retrospective analysis also showed patients with financial hardship have higher rates of opioid use, despite their fiscal condition. “Financial hardship is clinically impactful,” Courtney P. Williams, DrPH, assistant professor in the division of General Internal Medicine and Population Science at The University of Alabama at Birmingham (UAB) Heersink School of Medicine and associate scientist at O’Neal Comprehensive Cancer Center, told

Emergency department imaging protocol for triaging visual symptoms, prefilled syringes and endophthalmitis rates, GLP-1 RAs and sight-threatening diabetic retinopathy, lactic acid as a uveal melanoma marker, drugs associated with cataracts in children.

Ruptured dermoid cysts can often have atypical presentations and be challenging to manage. We report 3 cases of pediatric patients with ruptured dermoid cysts. Case 1 was a 16-year-old boy with an enlarging left superotemporal orbital mass who presented with 2 days of acute inflammation. Computed tomography revealed a well-circumscribed lesion that was excised. Histopathology confirmed a ruptured dermoid cyst. Case 2 was a 4-year-old girl with a right superotemporal orbital mass that enlarged following trauma.

The purpose of the study was to investigate changes in aqueous humour outflow (AHO) after the Elios glaucoma procedure (excimer laser trabeculostomy, ELT) using sequential AHO angiography. AHO angiography using two different tracers was performed in six eyes of five patients undergoing cataract surgery combined with ELT. AHO was compared in regions of interest in the nasal quadrant. AHO improved significantly after ELT (p=0.03) overall, and each patient showed individual, qualitative AHO improvement. Interestingly, AHO improvement extended beyond the site of ELT application. Further studies are needed to investigate the correlation of AHO improvement and clinical efficacy.

Accurate assessment of refractive error remains a cornerstone in ophthalmic practice. The current gold standard is subjective refraction (SR), as it is considered to provide the most precise refractive status. Autorefractors have been routinely used in clinics to facilitate efficient daily ophthalmic workflow, offering a relatively rapid assessment of objective refraction (OR). In recent years, multifunctional diagnostic devices have gained considerable popularity. These systems combine OR with additional modalities such as aberrometry, tomo- and/or topography.

Muir–Torre syndrome (MTS), a variant of Lynch syndrome characterized by visceral malignancies and cutaneous sebaceous neoplasms, is defined by germline pathogenic variants in mismatch repair (MMR) genes. These Lynch-associated cancers include colorectal, endometrial, ovarian, and small bowel cancers, as well as tumors of the urinary tract and biliary tract.1 The most common sebaceous neoplasm in the periocular region is conventional poorly differentiated sebaceous carcinoma, a high-grade basaloid carcinoma usually without any mature sebocytic differentiation and frequently showing TP53 mutation and/or RB1 loss, which is generally not related to MMR deficiency or MTS.

A longitudinal OCT imaging study identified three distinct patterns of ellipsoid zone loss in macular telangiectasia type 2 (MacTel) corresponding with different rates of disease progression.

Sports-related injuries are extremely common in every eye doctor’s practice. These injuries are more common in younger patients between the ages of 10 and 19 years, in male patients, during competition vs. practice and especially when protective eye wear is not used. For example, 97% of injuries in basketball, baseball/softball and fishing occur in individuals not wearing protective eye wear. The common causes include trauma from balls, hands/fingers, heads, knees, elbows, rackets/sticks and fishing lures/rods. Common injuries, in elevating severity, include periocular contusion,

Sports-related injuries are extremely common in every eye doctor’s practice. These injuries are more common in younger patients between the ages of 10 and 19 years, in male patients, during competition vs. practice and especially when protective eye wear is not used. For example, 97% of injuries in basketball, baseball/softball and fishing occur in individuals not wearing protective eye wear. The common causes include trauma from balls, hands/fingers, heads, knees, elbows, rackets/sticks and fishing lures/rods. Common injuries, in elevating severity, include periocular contusion,

Editor’s note: This is a developing news story. Please check back soon for updates. Total30 multifocal for astigmatism, a monthly toric lens for patients with presbyopia, is now available in the U.S., according to a press release from Alcon. The lens features Alcon’s water gradient technology, enabling its surface to be “nearly 100%” water, as well as ultraviolet blocking and blue-violet light filtration, according to the release. It also uses Alcon’s Celligent technology to work against bacteria and lipid deposits. The lens leverages the company’s Precision

Editor’s note: This is a developing news story. Please check back soon for updates. Total30 multifocal for astigmatism, a monthly toric lens for patients with presbyopia, is now available in the U.S., according to a press release from Alcon. The lens features Alcon’s water gradient technology, enabling its surface to be “nearly 100%” water, as well as ultraviolet blocking and blue-violet light filtration, according to the release. It also uses Alcon’s Celligent technology to work against bacteria and lipid deposits. The lens leverages the company’s Precision

Expert witnesses discussed the impact of federal regulations and administrative burden on physician burnout in a recent hearing held by the U.S. Senate Special Committee on Aging. “Today, we will look at how Washington’s regulations and red tape play into this crisis, and what we can do to fix it so our doctors can spend more time caring for patients and less time navigating bureaucracy,” committee chairman Sen. Rick Scott (R-Fla.), said in his opening statement. “We’ll hear from witnesses who interact with physicians at all levels.” Key points of discussion included difficulties managing

Expert witnesses discussed the impact of federal regulations and administrative burden on physician burnout in a recent hearing held by the U.S. Senate Special Committee on Aging. “Today, we will look at how Washington’s regulations and red tape play into this crisis, and what we can do to fix it so our doctors can spend more time caring for patients and less time navigating bureaucracy,” committee chairman Sen. Rick Scott (R-Fla.), said in his opening statement. “We’ll hear from witnesses who interact with physicians at all levels.” Key points of discussion included difficulties managing

Objective In retrocaruncular medial decompression, the incision is small relative to the depth of the surgical space, and haemorrhage may obscure vision. Measures that minimise bleeding are most important to improve visualisation and facilitate the procedure. Despite this, there is no consensus regarding the effect of nasal packing with a vasoconstrictive agent. The aim of this study was to see if haemorrhage during external medial decompression could be reduced by nasal packing. Methods and analysis A randomised, non-blinded, prospective study in which patients listed for orbital medial wall decompression at St Erik Eye Hospital, Sweden, were recruited. Patients were randomised to receive either nasal packing with a 4%+0.02% Cocaine Hydrochloride-Adrenaline solution or the control group. Intraoperative bleeding was quantified by weighing the suction device before and after the procedure. Results A total of 46 medial orbital wall decompressions in 37 patients were included in the final analysis. The treatment group, which received nasal packing, demonstrated significantly reduced intraoperative bleeding compared with the control group (median 9.40 g vs 30.10 g, p

Publication date: Available online 17 February 2026 Source: Experimental Eye Research Author(s): Chia-Ying Tsai, Shang-Chih Yang, Wei-Lun Huang, Yi-Ting Hou, Vladlen Klochkov, Mei-Yun Chen, Shu-Lang Liao, Wei-Li Chen

In the originally published article, the Funding/Support information was incorrect. The Funding/Support section should be corrected as follows.

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To evaluate the risk of demyelinating disease and optic neuritis among patients treated with TNF-α inhibitors using a large, nationwide electronic health record database.

The Rabb-Venable program is a research mentorship initiative established in 2000 to foster interest in ophthalmology. This report demonstrates the program’s contributions to workforce diversity and offers an overview of the alumni’s practice locations.

Evaluates visual outcomes following small-aperture intraocular lens implantation in post-refractive surgery patients undergoing cataract surgery