oliolabs.bsky.social
@oliolabs.bsky.social
We also found that side effects fluctuate with estrogen levels and estrous cycle phases in humans and mice respectively
March 19, 2025 at 7:27 PM
GLP-1 receptor expression is higher in females than males in parts of the brain associated with pain and nausea
March 19, 2025 at 7:27 PM
Female rats and mice display significantly more nausea-associated behavior compared to males (Kaolin intake is a measure of nausea in rats)
March 19, 2025 at 7:27 PM
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70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men.

What is driving this difference?

We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out:
March 19, 2025 at 7:27 PM