@oliolabs.bsky.social
Reposted
Some really cool work we've been doing @oliolabs.bsky.social. New science opens the door to better medicines.
Sex differences in GLP-1 signaling across species https://www.biorxiv.org/content/10.1101/2025.03.17.643822v1
March 19, 2025 at 10:16 PM
Some really cool work we've been doing @oliolabs.bsky.social. New science opens the door to better medicines.
We are building our platforms to solve these problems, and deliver better outcomes with fewer side effects to more people. Get in touch if you want to be a part of our vision. www.oliolabs.co
March 19, 2025 at 7:27 PM
We are building our platforms to solve these problems, and deliver better outcomes with fewer side effects to more people. Get in touch if you want to be a part of our vision. www.oliolabs.co
We also found that side effects fluctuate with estrogen levels and estrous cycle phases in humans and mice respectively
March 19, 2025 at 7:27 PM
We also found that side effects fluctuate with estrogen levels and estrous cycle phases in humans and mice respectively
GLP-1 receptor expression is higher in females than males in parts of the brain associated with pain and nausea
March 19, 2025 at 7:27 PM
GLP-1 receptor expression is higher in females than males in parts of the brain associated with pain and nausea
Female rats and mice display significantly more nausea-associated behavior compared to males (Kaolin intake is a measure of nausea in rats)
March 19, 2025 at 7:27 PM
Female rats and mice display significantly more nausea-associated behavior compared to males (Kaolin intake is a measure of nausea in rats)
Women taking GLP1-R agonists experience more than twice the rate of persistent nausea and vomiting compared to men
March 19, 2025 at 7:27 PM
Women taking GLP1-R agonists experience more than twice the rate of persistent nausea and vomiting compared to men
Check out what we're working on at Olio Labs!
70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men.
What is driving this difference?
We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out:
70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men.
What is driving this difference?
We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out:
March 19, 2025 at 7:27 PM
Check out what we're working on at Olio Labs!
70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men.
What is driving this difference?
We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out:
70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men.
What is driving this difference?
We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out: