@oleuns.bsky.social
Reposted
Using cryo-EM, we determined OBP structures at up to 2.8 Å resolution in multiple states:
1. bound to HSV-1 origin of replication (OriS) DNA
2. with a non-hydrolyzable ATP analog
3. as monomer, dimer, and higher-order assemblies
1. bound to HSV-1 origin of replication (OriS) DNA
2. with a non-hydrolyzable ATP analog
3. as monomer, dimer, and higher-order assemblies
October 23, 2025 at 6:40 AM
Using cryo-EM, we determined OBP structures at up to 2.8 Å resolution in multiple states:
1. bound to HSV-1 origin of replication (OriS) DNA
2. with a non-hydrolyzable ATP analog
3. as monomer, dimer, and higher-order assemblies
1. bound to HSV-1 origin of replication (OriS) DNA
2. with a non-hydrolyzable ATP analog
3. as monomer, dimer, and higher-order assemblies
Reposted
📜 The Herpes simplex Origin Binding Protein: Mechanisms for sequence specific DNA binding and dimerization revealed by Cryo-EM
🧑🔬 @emilgustavsson.bsky.social , Kay Grünewald, Per Elias, @bmhallberg.bsky.social
📔 Nucleic Acids Research @narjournal.bsky.social
🔗 doi.org/10.1093/nar/...
🧑🔬 @emilgustavsson.bsky.social , Kay Grünewald, Per Elias, @bmhallberg.bsky.social
📔 Nucleic Acids Research @narjournal.bsky.social
🔗 doi.org/10.1093/nar/...
The herpes simplex origin-binding protein: mechanisms for sequence-specific DNA binding and dimerization revealed by Cryo-EM
Abstract. Herpes simplex viruses 1 and 2 (HSV-1,2) present growing treatment challenges due to increasing resistance to antivirals targeting viral DNA poly
doi.org
October 23, 2025 at 6:38 AM
📜 The Herpes simplex Origin Binding Protein: Mechanisms for sequence specific DNA binding and dimerization revealed by Cryo-EM
🧑🔬 @emilgustavsson.bsky.social , Kay Grünewald, Per Elias, @bmhallberg.bsky.social
📔 Nucleic Acids Research @narjournal.bsky.social
🔗 doi.org/10.1093/nar/...
🧑🔬 @emilgustavsson.bsky.social , Kay Grünewald, Per Elias, @bmhallberg.bsky.social
📔 Nucleic Acids Research @narjournal.bsky.social
🔗 doi.org/10.1093/nar/...