Seamus O'Brien
@obriense.bsky.social
Antibiotic developer. Seabird lover, Arsenal, Rhinos, Leinster, Eagles, Celtics and RedSox, Film noir fan
Reposted by Seamus O'Brien
📊 2025 progress in GARDP’s DER programme
🤝Partnered with the Institute of Science Tokyo to explore protein-compound structures, aiming to develop new antibiotics for drug-resistant infections.
🔎Shared new DER research at global meetings.
🔗https://bit.pulse.ly/sp5uubtrqa
#WAAW2025
🤝Partnered with the Institute of Science Tokyo to explore protein-compound structures, aiming to develop new antibiotics for drug-resistant infections.
🔎Shared new DER research at global meetings.
🔗https://bit.pulse.ly/sp5uubtrqa
#WAAW2025
Discovery & exploratory research | GARDP
Growing drug resistance is outpacing the development of antibiotics for the most difficult-to-treat infections. Producing such antibiotics starts with the earli
bit.pulse.ly
November 23, 2025 at 3:59 PM
📊 2025 progress in GARDP’s DER programme
🤝Partnered with the Institute of Science Tokyo to explore protein-compound structures, aiming to develop new antibiotics for drug-resistant infections.
🔎Shared new DER research at global meetings.
🔗https://bit.pulse.ly/sp5uubtrqa
#WAAW2025
🤝Partnered with the Institute of Science Tokyo to explore protein-compound structures, aiming to develop new antibiotics for drug-resistant infections.
🔎Shared new DER research at global meetings.
🔗https://bit.pulse.ly/sp5uubtrqa
#WAAW2025
Reposted by Seamus O'Brien
Reposted by Seamus O'Brien
Gonorrhoea accounts for over 82 million new cases each year and has had no new treatment in more than 40 years.
GARDP and Innoviva Specialty Therapeutics have co-developed zoliflodacin, an investigational first-in-class oral antibiotic now under FDA review.
THIS IS BIG.
#WAAW2025 #AMR
GARDP and Innoviva Specialty Therapeutics have co-developed zoliflodacin, an investigational first-in-class oral antibiotic now under FDA review.
THIS IS BIG.
#WAAW2025 #AMR
November 19, 2025 at 1:00 PM
Reposted by Seamus O'Brien
If you weren't able to attend #GAMRIC2025, or you want to catch up on sessions you missed, a comprehensive round-up is now live, covering each session of the conference in detail ➡️ https://www.gamric.org/about-gamric/conference-round-up/
@carb-x.bsky.social @escmid.bsky.social @gardp.bsky.social
@carb-x.bsky.social @escmid.bsky.social @gardp.bsky.social
Conference round-up
www.gamric.org
November 11, 2025 at 9:15 AM
If you weren't able to attend #GAMRIC2025, or you want to catch up on sessions you missed, a comprehensive round-up is now live, covering each session of the conference in detail ➡️ https://www.gamric.org/about-gamric/conference-round-up/
@carb-x.bsky.social @escmid.bsky.social @gardp.bsky.social
@carb-x.bsky.social @escmid.bsky.social @gardp.bsky.social
Reposted by Seamus O'Brien
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics
By Kuan-Yi Lu, Brian Conlon & colleagues.
#microsky
www.nature.com/articles/s41...
By Kuan-Yi Lu, Brian Conlon & colleagues.
#microsky
www.nature.com/articles/s41...
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology
The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced t...
www.nature.com
October 15, 2025 at 4:52 PM
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics
By Kuan-Yi Lu, Brian Conlon & colleagues.
#microsky
www.nature.com/articles/s41...
By Kuan-Yi Lu, Brian Conlon & colleagues.
#microsky
www.nature.com/articles/s41...
Reposted by Seamus O'Brien
GARDP’s Executive Director Dr Manica Balasegaram writes about the urgent need to revive antibiotic R&D in the Financial Times. Without it, patients may survive cancer, only to lose their lives from untreatable infections.
📖 Read the op-ed here (subscriber-only): www.ft.com/content/196f...
📖 Read the op-ed here (subscriber-only): www.ft.com/content/196f...
Antibiotic resistance is the greatest threat to cancer patients
Investing in new oncology drugs without building up an effective arsenal against infections is a false economy
www.ft.com
September 17, 2025 at 6:00 AM
GARDP’s Executive Director Dr Manica Balasegaram writes about the urgent need to revive antibiotic R&D in the Financial Times. Without it, patients may survive cancer, only to lose their lives from untreatable infections.
📖 Read the op-ed here (subscriber-only): www.ft.com/content/196f...
📖 Read the op-ed here (subscriber-only): www.ft.com/content/196f...
Reposted by Seamus O'Brien
Reposted by Seamus O'Brien
Every 2.8 seconds, someone dies of sepsis. That’s 1 in 5 deaths worldwide.
This #WorldSepsisDay, we share 5 key facts about sepsis and 5 actions GARDP is taking with partners worldwide to fight it.
👉 Swipe through. Share it with your network.
#Sepsis #AMR #GARDP
This #WorldSepsisDay, we share 5 key facts about sepsis and 5 actions GARDP is taking with partners worldwide to fight it.
👉 Swipe through. Share it with your network.
#Sepsis #AMR #GARDP
September 13, 2025 at 9:31 AM
Every 2.8 seconds, someone dies of sepsis. That’s 1 in 5 deaths worldwide.
This #WorldSepsisDay, we share 5 key facts about sepsis and 5 actions GARDP is taking with partners worldwide to fight it.
👉 Swipe through. Share it with your network.
#Sepsis #AMR #GARDP
This #WorldSepsisDay, we share 5 key facts about sepsis and 5 actions GARDP is taking with partners worldwide to fight it.
👉 Swipe through. Share it with your network.
#Sepsis #AMR #GARDP
Incredible interview on @bbcradio4 Today programme. Great credit to Nick Robinson for standing up for his and BBC's credibility and independent journalism in the face of a bully representing a desperate and brutal Israel state #BBCR4 #aidnow #stopthefamine #gaza
July 25, 2025 at 7:38 AM
Incredible interview on @bbcradio4 Today programme. Great credit to Nick Robinson for standing up for his and BBC's credibility and independent journalism in the face of a bully representing a desperate and brutal Israel state #BBCR4 #aidnow #stopthefamine #gaza
Reposted by Seamus O'Brien
📰 The Nikkan Kogyo Shimbun covers GARDP’s new joint research with Institute of Science Tokyo on developing novel antibiotics to address drug-resistant infections.
Read the story here : www.nikkan.co.jp/articles/vie...
Read the story here : www.nikkan.co.jp/articles/vie...
東京科学大とGARDP、抗菌薬を共同研究
東京科学大学とグローバル抗菌薬研究開発パートナーシップ（ＧＡＲＤＰ）は、新しい抗菌薬の開発に向けた共同研究契約を締結した。......
www.nikkan.co.jp
July 25, 2025 at 6:53 AM
📰 The Nikkan Kogyo Shimbun covers GARDP’s new joint research with Institute of Science Tokyo on developing novel antibiotics to address drug-resistant infections.
Read the story here : www.nikkan.co.jp/articles/vie...
Read the story here : www.nikkan.co.jp/articles/vie...
Reposted by Seamus O'Brien
Big thanks to the experts at our #AMR workshop during ReAct Africa Network in Lusaka—working to prioritize key antibiotics for treating childhood sepsis in Sub-Saharan Africa. 💊🌍
#Sepsis #ChildHealth #GARDP
#Sepsis #ChildHealth #GARDP
June 14, 2025 at 6:00 AM
Big thanks to the experts at our #AMR workshop during ReAct Africa Network in Lusaka—working to prioritize key antibiotics for treating childhood sepsis in Sub-Saharan Africa. 💊🌍
#Sepsis #ChildHealth #GARDP
#Sepsis #ChildHealth #GARDP
Reposted by Seamus O'Brien
Join Dr Steven Tong & Dr Patrick Harris to delve into how post-licensing clinical trials help us use antibiotics more effectively.
🗓️ 22 May 2025 | ⏰ 09:30–11:00 CEST
💬 Live Q&A included
🔗 Register now: tinyurl.com/2kr3cbym
#REVIVE #ClinicalTrials #InfectiousDiseases #REVIVEWebinar #GARDP
🗓️ 22 May 2025 | ⏰ 09:30–11:00 CEST
💬 Live Q&A included
🔗 Register now: tinyurl.com/2kr3cbym
#REVIVE #ClinicalTrials #InfectiousDiseases #REVIVEWebinar #GARDP
May 14, 2025 at 9:35 AM
Join Dr Steven Tong & Dr Patrick Harris to delve into how post-licensing clinical trials help us use antibiotics more effectively.
🗓️ 22 May 2025 | ⏰ 09:30–11:00 CEST
💬 Live Q&A included
🔗 Register now: tinyurl.com/2kr3cbym
#REVIVE #ClinicalTrials #InfectiousDiseases #REVIVEWebinar #GARDP
🗓️ 22 May 2025 | ⏰ 09:30–11:00 CEST
💬 Live Q&A included
🔗 Register now: tinyurl.com/2kr3cbym
#REVIVE #ClinicalTrials #InfectiousDiseases #REVIVEWebinar #GARDP
Reposted by Seamus O'Brien
🚨Out now!
A new study that shows that typhoid toxin disrupts the blood–brain barrier leading to vascular leakage, inflammation and neurological symptoms, causing encephalopathy in typhoid fever. Corticosteroids help mitigate these effects.
#MicroSky
www.nature.com/articles/s41...
A new study that shows that typhoid toxin disrupts the blood–brain barrier leading to vascular leakage, inflammation and neurological symptoms, causing encephalopathy in typhoid fever. Corticosteroids help mitigate these effects.
#MicroSky
www.nature.com/articles/s41...
Typhoid toxin causes neuropathology by disrupting the blood–brain barrier - Nature Microbiology
This study shows that typhoid toxin disrupts the blood–brain barrier leading to vascular leakage, inflammation and neurological symptoms, causing encephalopathy in typhoid fever. Corticosteroids help ...
www.nature.com
May 9, 2025 at 2:53 PM
🚨Out now!
A new study that shows that typhoid toxin disrupts the blood–brain barrier leading to vascular leakage, inflammation and neurological symptoms, causing encephalopathy in typhoid fever. Corticosteroids help mitigate these effects.
#MicroSky
www.nature.com/articles/s41...
A new study that shows that typhoid toxin disrupts the blood–brain barrier leading to vascular leakage, inflammation and neurological symptoms, causing encephalopathy in typhoid fever. Corticosteroids help mitigate these effects.
#MicroSky
www.nature.com/articles/s41...
Reposted by Seamus O'Brien
Great discussions this morning at the Indo-Swiss AMR Innovation Dialogue in partnership with Swissnex
Valuable exchange with partners and experts from India on strengthening innovation and collaboration to tackle drug-resistant infections. 🤝💡
#AMR #Innovation #India #Switzerland #Partnerships #R&D
Valuable exchange with partners and experts from India on strengthening innovation and collaboration to tackle drug-resistant infections. 🤝💡
#AMR #Innovation #India #Switzerland #Partnerships #R&D
May 2, 2025 at 11:59 AM
Great discussions this morning at the Indo-Swiss AMR Innovation Dialogue in partnership with Swissnex
Valuable exchange with partners and experts from India on strengthening innovation and collaboration to tackle drug-resistant infections. 🤝💡
#AMR #Innovation #India #Switzerland #Partnerships #R&D
Valuable exchange with partners and experts from India on strengthening innovation and collaboration to tackle drug-resistant infections. 🤝💡
#AMR #Innovation #India #Switzerland #Partnerships #R&D
Important modelling data from our access team @gardp.bsky.social antibiotics that can be used optimally to address difficult to treat resistant infections are not available where they are needed the most #AMR #Antibiotics #GlobalHealth
🚨 This is Big!
New GARDP research shows that people with multidrug-resistant infections in LMICs are not receiving the appropriate antibiotics because of large gaps in access. Improving access and developing new antibiotics must be a priority,
📖 Read the study
www.thelancet.com/journals/lan...
New GARDP research shows that people with multidrug-resistant infections in LMICs are not receiving the appropriate antibiotics because of large gaps in access. Improving access and developing new antibiotics must be a priority,
📖 Read the study
www.thelancet.com/journals/lan...
May 2, 2025 at 7:27 AM
Important modelling data from our access team @gardp.bsky.social antibiotics that can be used optimally to address difficult to treat resistant infections are not available where they are needed the most #AMR #Antibiotics #GlobalHealth
Reposted by Seamus O'Brien
🚨 This is Big!
New GARDP research shows that people with multidrug-resistant infections in LMICs are not receiving the appropriate antibiotics because of large gaps in access. Improving access and developing new antibiotics must be a priority,
📖 Read the study
www.thelancet.com/journals/lan...
New GARDP research shows that people with multidrug-resistant infections in LMICs are not receiving the appropriate antibiotics because of large gaps in access. Improving access and developing new antibiotics must be a priority,
📖 Read the study
www.thelancet.com/journals/lan...
May 1, 2025 at 8:07 AM
🚨 This is Big!
New GARDP research shows that people with multidrug-resistant infections in LMICs are not receiving the appropriate antibiotics because of large gaps in access. Improving access and developing new antibiotics must be a priority,
📖 Read the study
www.thelancet.com/journals/lan...
New GARDP research shows that people with multidrug-resistant infections in LMICs are not receiving the appropriate antibiotics because of large gaps in access. Improving access and developing new antibiotics must be a priority,
📖 Read the study
www.thelancet.com/journals/lan...
@markradcliffe.bsky.social green Isaac for the green, come on. Am I taking this too seriously
April 19, 2025 at 8:51 AM
@markradcliffe.bsky.social green Isaac for the green, come on. Am I taking this too seriously
Reposted by Seamus O'Brien
WHO Member States have finalized a draft Pandemic Agreement to strengthen global pandemic prevention and response. It includes commitments to equity, a #OneHealth approach, and respecting national sovereignty. Proposal will be considered at World Health Assembly in May.
www.who.int/news/item/16...
www.who.int/news/item/16...
WHO Member States conclude negotiations and make significant progress on draft pandemic agreement
After more than three years of intensive negotiations, WHO Member States took a major step forward in efforts to make the world safer from pandemics, by forging a draft agreement for consideration at ...
www.who.int
April 16, 2025 at 1:24 AM
WHO Member States have finalized a draft Pandemic Agreement to strengthen global pandemic prevention and response. It includes commitments to equity, a #OneHealth approach, and respecting national sovereignty. Proposal will be considered at World Health Assembly in May.
www.who.int/news/item/16...
www.who.int/news/item/16...
Thinking of all the staff at the wonderful RSPB Bempton Cliffs and the concern for the seabird breeding habitat with the potential oil spill of the East Yorks coast #RSPB #EastYorks #NorthSea #Tankercrash
March 10, 2025 at 4:26 PM
Thinking of all the staff at the wonderful RSPB Bempton Cliffs and the concern for the seabird breeding habitat with the potential oil spill of the East Yorks coast #RSPB #EastYorks #NorthSea #Tankercrash
Fly Eagles Fly #NFCChampions
UNSTOPPABLE ‼️
Saquon Barkley hit a blazing 20.15 mph on his run, marking his 14th carry this season over 20 mph, more than double the total of the next closest players, Derrick Henry and Jahmyr Gibbs (six each) 😱
Saquon Barkley hit a blazing 20.15 mph on his run, marking his 14th carry this season over 20 mph, more than double the total of the next closest players, Derrick Henry and Jahmyr Gibbs (six each) 😱
January 26, 2025 at 11:26 PM
Fly Eagles Fly #NFCChampions