NYU Pain Research Center
@nyupainresearch.bsky.social
The New York University Pain Research Center is dedicated to mechanistic and translational research on the neurobiology of chronic pain.
Website: https://dental.nyu.edu/research/pain-research-center.html
Huge thanks to everyone who joined the #PRC Lunch at #SfN — inspiring conversations and incredible research collaborations emerged! 🙌🧠 #PRCmembers #SfN #SanDiego #circleJLabs @sfn.org @sdavidson.bsky.social @pazduran.bsky.social @elisadamo.bsky.social
November 19, 2025 at 4:26 PM
Huge thanks to everyone who joined the #PRC Lunch at #SfN — inspiring conversations and incredible research collaborations emerged! 🙌🧠 #PRCmembers #SfN #SanDiego #circleJLabs @sfn.org @sdavidson.bsky.social @pazduran.bsky.social @elisadamo.bsky.social
Reposted by NYU Pain Research Center
🎉 Join us for the 1st NYC Area Pain Research Meet-Up!
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
November 11, 2025 at 7:33 PM
🎉 Join us for the 1st NYC Area Pain Research Meet-Up!
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
The NYU PRC is excited to welcome Farnaz Shamsi as one of our newest associate members! 🎉 Farnaz studies the neuroimmune regulation of energy balance and adipose tissue function, exploring how these systems shape metabolic health and contribute to obesity and related diseases.
November 13, 2025 at 5:22 PM
The NYU PRC is excited to welcome Farnaz Shamsi as one of our newest associate members! 🎉 Farnaz studies the neuroimmune regulation of energy balance and adipose tissue function, exploring how these systems shape metabolic health and contribute to obesity and related diseases.
Enteric neurons join the pain conversation! New paper shows that cholinergic circuits in the colon signals through DRG pathways, especially after inflammation. www.cell.com/neuron/fullt...
An enteric-DRG pathway for interoception and visceral pain in mice
Wang et al. reveal a neuroanatomical and functional crosstalk between cholinergic
enteric neurons and sensory neurons of the dorsal root ganglia that mediates colonic
interoception. While this pathway...
www.cell.com
November 13, 2025 at 3:17 PM
Enteric neurons join the pain conversation! New paper shows that cholinergic circuits in the colon signals through DRG pathways, especially after inflammation. www.cell.com/neuron/fullt...
Reposted by NYU Pain Research Center
Are you a researcher in #touch #pain #itch #somatosensation or #interoception? Come join us at the Somatosensation and Interoception social at #Sfn2025! Co-hosted with
@karalmarshall.bsky.social @sdavidson.bsky.social
@karalmarshall.bsky.social @sdavidson.bsky.social
November 13, 2025 at 2:12 PM
Are you a researcher in #touch #pain #itch #somatosensation or #interoception? Come join us at the Somatosensation and Interoception social at #Sfn2025! Co-hosted with
@karalmarshall.bsky.social @sdavidson.bsky.social
@karalmarshall.bsky.social @sdavidson.bsky.social
New insights into human sensory biology: The human DRG atlas is here. #painresearch #DRG #neuroscience www.biorxiv.org/content/10.1...
A Reference Atlas of the Human Dorsal Root Ganglion
Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic...
www.biorxiv.org
November 12, 2025 at 8:31 PM
New insights into human sensory biology: The human DRG atlas is here. #painresearch #DRG #neuroscience www.biorxiv.org/content/10.1...
🎉 Join us for the 1st NYC Area Pain Research Meet-Up!
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
November 11, 2025 at 7:33 PM
🎉 Join us for the 1st NYC Area Pain Research Meet-Up!
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
🗓 Fri, Dec 5 | 3–6 PM
📍 NYU Pain Research Center, 433 1st Ave
Don’t miss Dr. Steve Davidson’s keynote: “Humanizing Pain Neurobiology for Translational Gain” — plus great company & treats!
See you there! 💫 #PainResearch #NYCScience #Neurobiology
NYU Pain Research Center is expanding! 💥 Seeking brilliant minds (Assistant or Associate Professor, tenure track) to explore chronic pain mechanisms & therapies. Join our mission to transform pain research. Apply now! 🧠✨ #Research #AcademicJobs apply.interfolio.com/176454
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November 11, 2025 at 4:19 PM
NYU Pain Research Center is expanding! 💥 Seeking brilliant minds (Assistant or Associate Professor, tenure track) to explore chronic pain mechanisms & therapies. Join our mission to transform pain research. Apply now! 🧠✨ #Research #AcademicJobs apply.interfolio.com/176454
PRC PI Research Talks for the win! 🎉
Our guest speakers — Brian L. Schmidt, Edwin Rosado-Olivieri, and Nestor Jimenez — shared powerful research insights and sparked thoughtful discussion across the PRC community. A huge thank you to each of them for inspiring the work we do!
Our guest speakers — Brian L. Schmidt, Edwin Rosado-Olivieri, and Nestor Jimenez — shared powerful research insights and sparked thoughtful discussion across the PRC community. A huge thank you to each of them for inspiring the work we do!
October 31, 2025 at 9:16 PM
PRC PI Research Talks for the win! 🎉
Our guest speakers — Brian L. Schmidt, Edwin Rosado-Olivieri, and Nestor Jimenez — shared powerful research insights and sparked thoughtful discussion across the PRC community. A huge thank you to each of them for inspiring the work we do!
Our guest speakers — Brian L. Schmidt, Edwin Rosado-Olivieri, and Nestor Jimenez — shared powerful research insights and sparked thoughtful discussion across the PRC community. A huge thank you to each of them for inspiring the work we do!
A new study: The Piomelli lab found that injury flips a metabolic switch in the spinal cord, fueling chronic pain. Restoring lost nutrients reactivates autophagy and stops pain from becoming chronic, hinting at diet-based ways to block pain persistence! www.sciencedirect.com/science/arti...
Metabolic reprogramming in the spinal cord drives the transition to pain chronicity
Acute injuries can progress into painful states that endure long after healing. The mechanisms underlying this transition remain unclear, but metaboli…
www.sciencedirect.com
October 24, 2025 at 8:48 PM
A new study: The Piomelli lab found that injury flips a metabolic switch in the spinal cord, fueling chronic pain. Restoring lost nutrients reactivates autophagy and stops pain from becoming chronic, hinting at diet-based ways to block pain persistence! www.sciencedirect.com/science/arti...
The Cancer Neuroscience Program at MD Anderson invites you to attend the International Cancer Neuroscience Symposium happening February 18–20, 2026, in the TMC³ Collaborative Building. mdanderson.cloud-cme.com/course/cours...
October 22, 2025 at 2:34 PM
The Cancer Neuroscience Program at MD Anderson invites you to attend the International Cancer Neuroscience Symposium happening February 18–20, 2026, in the TMC³ Collaborative Building. mdanderson.cloud-cme.com/course/cours...
The latest in PNAS: Endosome-targeted nanomedicines deliver PAR2 antagonists directly to intracellular signaling hubs → producing sustained analgesia. A paradigm shift in GPCR-based therapy.
Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia - PubMed
Although many internalized G protein-coupled receptors (GPCRs) continue to signal, the mechanisms and outcomes of intracellular GPCR signaling are uncertain due to the challenges of measuring…
buff.ly
October 17, 2025 at 7:01 PM
The latest in PNAS: Endosome-targeted nanomedicines deliver PAR2 antagonists directly to intracellular signaling hubs → producing sustained analgesia. A paradigm shift in GPCR-based therapy.
New research identifies a specific bacterial protease, Bfp1 from Bacteroides fragilis, that cleaves & activates host PAR2. This causes intestinal barrier disruption, sensitizes pain neurons, and triggers inflammation, leading to abdominal pain in IBD/IBS models. www.sciencedirect.com/science/arti...
A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation
Protease-activated receptor 2 (PAR2) is a central regulator of intestinal barrier function, inflammation, and pain. Upregulated intestinal proteolysis…
www.sciencedirect.com
October 17, 2025 at 4:42 PM
New research identifies a specific bacterial protease, Bfp1 from Bacteroides fragilis, that cleaves & activates host PAR2. This causes intestinal barrier disruption, sensitizes pain neurons, and triggers inflammation, leading to abdominal pain in IBD/IBS models. www.sciencedirect.com/science/arti...
Press release for 2 exciting papers from Bunnett and Jensen Lab researchers! #JensenLab #BunnettLab www.nyu.edu/about/news-p...
Microbiome and Nanoparticle Discoveries Hold Promise for Treating Gut Pain
Newly identified enzyme and targeted nanomedicines bring researchers closer to more effectively treating pain from digestive disorders
www.nyu.edu
October 17, 2025 at 4:36 PM
Press release for 2 exciting papers from Bunnett and Jensen Lab researchers! #JensenLab #BunnettLab www.nyu.edu/about/news-p...
New Cell Host & Microbe paper alert!
Chemoproteomics were used to uncover a previously unknown serine protease Bfp1 from B fragilis! This sneaky enzyme cleaves PAR2, setting off a chain reaction of barrier dysfunction, colonic inflammation, and nociceptor activation
pubmed.ncbi.nlm.nih.gov/41015045/
Chemoproteomics were used to uncover a previously unknown serine protease Bfp1 from B fragilis! This sneaky enzyme cleaves PAR2, setting off a chain reaction of barrier dysfunction, colonic inflammation, and nociceptor activation
pubmed.ncbi.nlm.nih.gov/41015045/
A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation - PubMed
Protease-activated receptor 2 (PAR<sub>2</sub>) is a central regulator of intestinal barrier function, inflammation, and pain. Upregulated intestinal proteolysis and PAR<sub>2</sub> signaling are impl...
pubmed.ncbi.nlm.nih.gov
October 16, 2025 at 8:07 PM
New Cell Host & Microbe paper alert!
Chemoproteomics were used to uncover a previously unknown serine protease Bfp1 from B fragilis! This sneaky enzyme cleaves PAR2, setting off a chain reaction of barrier dysfunction, colonic inflammation, and nociceptor activation
pubmed.ncbi.nlm.nih.gov/41015045/
Chemoproteomics were used to uncover a previously unknown serine protease Bfp1 from B fragilis! This sneaky enzyme cleaves PAR2, setting off a chain reaction of barrier dysfunction, colonic inflammation, and nociceptor activation
pubmed.ncbi.nlm.nih.gov/41015045/
Fascinating new work on the central mechanisms of sustained pain! A new study found an endogenous analgesic hub in the brain's parabrachial nucleus. Activity in neurons expressing the NPY receptor Y1 predicts chronic pain coping. www.nature.com/articles/s41...
A parabrachial hub for need-state control of enduring pain - Nature
Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.
www.nature.com
October 15, 2025 at 7:25 PM
Fascinating new work on the central mechanisms of sustained pain! A new study found an endogenous analgesic hub in the brain's parabrachial nucleus. Activity in neurons expressing the NPY receptor Y1 predicts chronic pain coping. www.nature.com/articles/s41...
Excited to share Bunnett lab's work on targeting compartmentalized GPCR signaling! Using endosome-accumulating nanoparticles, they selectively blocked intracellular PAR2, achieving complete, long-lasting pain relief in inflammatory disease models.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Nanomedicines targeting protease-activated receptor 2 in endosomes provide sustained analgesia | PNAS
Although many internalized G protein-coupled receptors (GPCRs) continue to signal,
the mechanisms and outcomes of intracellular GPCR signaling are ...
www.pnas.org
October 13, 2025 at 5:52 PM
Excited to share Bunnett lab's work on targeting compartmentalized GPCR signaling! Using endosome-accumulating nanoparticles, they selectively blocked intracellular PAR2, achieving complete, long-lasting pain relief in inflammatory disease models.
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
A new study finds that reducing mitochondrial ETC activity shields TRPV1⁺ nociceptors from excitotoxic damage by limiting calcium and ROS, revealing a built-in neuroprotective strategy. www.sciencedirect.com/science/arti...
Mitochondrial activity tunes nociceptor resilience to excitotoxicity
The capsaicin receptor, TRPV1, mediates the detection of noxious chemical and thermal stimuli by nociceptors, primary sensory neurons of the pain path…
www.sciencedirect.com
October 10, 2025 at 7:14 PM
A new study finds that reducing mitochondrial ETC activity shields TRPV1⁺ nociceptors from excitotoxic damage by limiting calcium and ROS, revealing a built-in neuroprotective strategy. www.sciencedirect.com/science/arti...
PRIMED Speaker Blake Kimmey (UPenn) Paging the PAG: Pain, Opioids & Relief. Epic talk on Periaqueductal gray opioid circuits for pain aversion & relief. Blake broke down how brain circuits in the PAG decide what hurts and what doesn’t. Stress, booze, and opioids all play a part!
October 10, 2025 at 6:43 PM
PRIMED Speaker Blake Kimmey (UPenn) Paging the PAG: Pain, Opioids & Relief. Epic talk on Periaqueductal gray opioid circuits for pain aversion & relief. Blake broke down how brain circuits in the PAG decide what hurts and what doesn’t. Stress, booze, and opioids all play a part!
Huge thanks to "3-Minute Mondays!" for this fantastic feature! Don't forget to subscribe @nyudentistry on #YouTube.... To learn more about the #NYU #PainResearchCenter. Click below to dive in! www.youtube.com/watch?v=naoQ... #YouTube #NYUDentistryoutubechannel #PainResearchCenter
"3-Minute Mondays!": NYU Pain Research Center
YouTube video by NYUDentistry
www.youtube.com
October 3, 2025 at 2:08 PM
Huge thanks to "3-Minute Mondays!" for this fantastic feature! Don't forget to subscribe @nyudentistry on #YouTube.... To learn more about the #NYU #PainResearchCenter. Click below to dive in! www.youtube.com/watch?v=naoQ... #YouTube #NYUDentistryoutubechannel #PainResearchCenter
Big congratulations to postdoc Sarah Najjar from the Margolis Lab on receiving a NIH K01 award to study serotonergic mechanisms of pain! 🌟 A huge step toward independence and groundbreaking discoveries ahead! 👏
September 19, 2025 at 8:15 PM
Big congratulations to postdoc Sarah Najjar from the Margolis Lab on receiving a NIH K01 award to study serotonergic mechanisms of pain! 🌟 A huge step toward independence and groundbreaking discoveries ahead! 👏
🎉 Congrats to Dr. Moayedi on receiving the Whitehead Fellowship! This project explores how sensory feedback from upper airway muscles supports voicing—unlocking neural pathways with big implications for treating airway disorders. 👏🧠💬
September 19, 2025 at 8:12 PM
🎉 Congrats to Dr. Moayedi on receiving the Whitehead Fellowship! This project explores how sensory feedback from upper airway muscles supports voicing—unlocking neural pathways with big implications for treating airway disorders. 👏🧠💬
The PRC PRIMED team is on fire! 🔥
They recently hosted an incredible virtual seminar featuring Dr. Rhian Stavely, who delivered a fascinating talk titled:
"Understanding Enteric Neuroplasticity to Inform Regenerative Therapies."
Exciting insights and cutting-edge science—well done, team!
They recently hosted an incredible virtual seminar featuring Dr. Rhian Stavely, who delivered a fascinating talk titled:
"Understanding Enteric Neuroplasticity to Inform Regenerative Therapies."
Exciting insights and cutting-edge science—well done, team!
September 19, 2025 at 8:06 PM
The PRC PRIMED team is on fire! 🔥
They recently hosted an incredible virtual seminar featuring Dr. Rhian Stavely, who delivered a fascinating talk titled:
"Understanding Enteric Neuroplasticity to Inform Regenerative Therapies."
Exciting insights and cutting-edge science—well done, team!
They recently hosted an incredible virtual seminar featuring Dr. Rhian Stavely, who delivered a fascinating talk titled:
"Understanding Enteric Neuroplasticity to Inform Regenerative Therapies."
Exciting insights and cutting-edge science—well done, team!
Huge news! The Moayedi Lab has officially received their first R01 grant to study the neural mechanisms of astringency transduction and sensation! Can we get a whoop whoop hooray?! 🥳🎉🪩 @yaldamoayedi.bsky.social
September 19, 2025 at 7:57 PM
Huge news! The Moayedi Lab has officially received their first R01 grant to study the neural mechanisms of astringency transduction and sensation! Can we get a whoop whoop hooray?! 🥳🎉🪩 @yaldamoayedi.bsky.social
A warm #welcome to Dr. Jordyn M. Boesch, our newest PRC Associate Member! 🐾 A board-certified veterinary anesthesiologist at Cornell, she’s now diving into translational research to bridge animal and human pain relief. #OneHealth #PainResearch blogs.cornell.edu/comparativep...
September 19, 2025 at 7:33 PM
A warm #welcome to Dr. Jordyn M. Boesch, our newest PRC Associate Member! 🐾 A board-certified veterinary anesthesiologist at Cornell, she’s now diving into translational research to bridge animal and human pain relief. #OneHealth #PainResearch blogs.cornell.edu/comparativep...