Neuropsychopharmacology
@npp-journal.bsky.social
Neuropsychopharmacology (NPP) is an official peer-reviewed publication of the American College of Neuropsychopharmacology.
We report discoveries and promote training & outreach initiatives.
We report discoveries and promote training & outreach initiatives.
#ThisWeekInNPP
Long-term high-fat diet in ♂️🐭 induces anxiety- & depression-like behavior and ⬆️ lipid droplet–accumulating microglia in 🧠, linking microglial lipid storage to neuroinflammatory mechanisms, which may underlie obesity-related psychiatric comorbidities
Long-term high-fat diet in ♂️🐭 induces anxiety- & depression-like behavior and ⬆️ lipid droplet–accumulating microglia in 🧠, linking microglial lipid storage to neuroinflammatory mechanisms, which may underlie obesity-related psychiatric comorbidities
Single-cell RNA sequencing uncovers molecular features underlying microglial lipid accumulation and depression-related behaviors in high-fat diet mouse model of obesity - Neuropsychopharmacology
Neuropsychopharmacology - Single-cell RNA sequencing uncovers molecular features underlying microglial lipid accumulation and depression-related behaviors in high-fat diet mouse model of obesity
www.nature.com
November 18, 2025 at 9:18 PM
#ThisWeekInNPP
Long-term high-fat diet in ♂️🐭 induces anxiety- & depression-like behavior and ⬆️ lipid droplet–accumulating microglia in 🧠, linking microglial lipid storage to neuroinflammatory mechanisms, which may underlie obesity-related psychiatric comorbidities
Long-term high-fat diet in ♂️🐭 induces anxiety- & depression-like behavior and ⬆️ lipid droplet–accumulating microglia in 🧠, linking microglial lipid storage to neuroinflammatory mechanisms, which may underlie obesity-related psychiatric comorbidities
#ThisWeekInNPP
A small ventrolateral orbitofrontal cortex (vlOFC)–to–dorsolateral striatum (DLS) circuit uses BDNF signaling to limit alcohol consumption in 🐭
Chronic binge drinking ⬆️ vlOFC BDNF, while restoring BDNF specifically in the vlOFC–DLS pathway ⬇️ alcohol intake, seeking, & relapse
A small ventrolateral orbitofrontal cortex (vlOFC)–to–dorsolateral striatum (DLS) circuit uses BDNF signaling to limit alcohol consumption in 🐭
Chronic binge drinking ⬆️ vlOFC BDNF, while restoring BDNF specifically in the vlOFC–DLS pathway ⬇️ alcohol intake, seeking, & relapse
BDNF in ventrolateral orbitofrontal cortex to dorsolateral striatum circuit moderates alcohol consumption, seeking and relapse - Neuropsychopharmacology
Neuropsychopharmacology - BDNF in ventrolateral orbitofrontal cortex to dorsolateral striatum circuit moderates alcohol consumption, seeking and relapse
www.nature.com
November 18, 2025 at 9:18 PM
#ThisWeekInNPP
A small ventrolateral orbitofrontal cortex (vlOFC)–to–dorsolateral striatum (DLS) circuit uses BDNF signaling to limit alcohol consumption in 🐭
Chronic binge drinking ⬆️ vlOFC BDNF, while restoring BDNF specifically in the vlOFC–DLS pathway ⬇️ alcohol intake, seeking, & relapse
A small ventrolateral orbitofrontal cortex (vlOFC)–to–dorsolateral striatum (DLS) circuit uses BDNF signaling to limit alcohol consumption in 🐭
Chronic binge drinking ⬆️ vlOFC BDNF, while restoring BDNF specifically in the vlOFC–DLS pathway ⬇️ alcohol intake, seeking, & relapse
#ThisWeekInNPP
Treatment-resistant schizophrenia (TRS) patients had ⬆️ dorsal substantia nigra neuromelanin signal vs controls, suggesting distinct dopamine pathway involvement in TRS & underscoring a need for multimodal imaging to clarify mechanisms of treatment resistance
Treatment-resistant schizophrenia (TRS) patients had ⬆️ dorsal substantia nigra neuromelanin signal vs controls, suggesting distinct dopamine pathway involvement in TRS & underscoring a need for multimodal imaging to clarify mechanisms of treatment resistance
Associations of neuromelanin in the substantia nigra with antipsychotic response in schizophrenia - Neuropsychopharmacology
Neuropsychopharmacology - Associations of neuromelanin in the substantia nigra with antipsychotic response in schizophrenia
www.nature.com
November 18, 2025 at 9:18 PM
#ThisWeekInNPP
Treatment-resistant schizophrenia (TRS) patients had ⬆️ dorsal substantia nigra neuromelanin signal vs controls, suggesting distinct dopamine pathway involvement in TRS & underscoring a need for multimodal imaging to clarify mechanisms of treatment resistance
Treatment-resistant schizophrenia (TRS) patients had ⬆️ dorsal substantia nigra neuromelanin signal vs controls, suggesting distinct dopamine pathway involvement in TRS & underscoring a need for multimodal imaging to clarify mechanisms of treatment resistance
Dr. Herman is Co-PI of the Psychiatry-Neurosurgery Herman Darrow Lab at University of Minnesota, focusing on how decision-making circuits malfunction in addiction, mood, pain & movement disorders, using invasive & noninvasive neurophysiology & neuromodulation 🧠 #ACNP2026
November 17, 2025 at 9:18 PM
Dr. Herman is Co-PI of the Psychiatry-Neurosurgery Herman Darrow Lab at University of Minnesota, focusing on how decision-making circuits malfunction in addiction, mood, pain & movement disorders, using invasive & noninvasive neurophysiology & neuromodulation 🧠 #ACNP2026
Dr. Tansey (@ryanntansey.bsky.social) uses multimodal neuroimaging techniques (mainly functional MRI, but also magnetic resonance spectroscopy & diffusion MRI) to gain a deeper etiological understanding of psychiatric disorders & develop novel treatments 🧠💊 #ACNP2026
November 17, 2025 at 9:18 PM
Dr. Tansey (@ryanntansey.bsky.social) uses multimodal neuroimaging techniques (mainly functional MRI, but also magnetic resonance spectroscopy & diffusion MRI) to gain a deeper etiological understanding of psychiatric disorders & develop novel treatments 🧠💊 #ACNP2026
Dr. Clara Zundel (@clarazundel.bsky.social) examines the neurobehavioral mechanisms linking environmental toxicants (e.g., air pollution) to psychiatric outcomes 😷🧠
She also leads science advocacy & outreach efforts, aiming to connect neuroscience with public health & community impact #ACNP2026
She also leads science advocacy & outreach efforts, aiming to connect neuroscience with public health & community impact #ACNP2026
November 17, 2025 at 9:18 PM
Dr. Clara Zundel (@clarazundel.bsky.social) examines the neurobehavioral mechanisms linking environmental toxicants (e.g., air pollution) to psychiatric outcomes 😷🧠
She also leads science advocacy & outreach efforts, aiming to connect neuroscience with public health & community impact #ACNP2026
She also leads science advocacy & outreach efforts, aiming to connect neuroscience with public health & community impact #ACNP2026
Dr. Rough examines polysubstance use in socially housed ♀️ & ♂️ nonhuman primates 🐒, with the goal of creating a highly translational animal model that improves medication development for cocaine use disorder from bench to bedside #ACNP2026
November 17, 2025 at 9:18 PM
Dr. Rough examines polysubstance use in socially housed ♀️ & ♂️ nonhuman primates 🐒, with the goal of creating a highly translational animal model that improves medication development for cocaine use disorder from bench to bedside #ACNP2026
Here is Week #1 installment for @acnporg.bsky.social Travel Awardees of #ACNP2026
Dr. Mia Rough, Wake Forest University
Dr. Clara Zundel, Wayne State University
Dr. Ryann Tansey, University of Calgary
Dr. Alexander Herman, University of Minnesota
@clarazundel.bsky.social
@ryanntansey.bsky.social
Dr. Mia Rough, Wake Forest University
Dr. Clara Zundel, Wayne State University
Dr. Ryann Tansey, University of Calgary
Dr. Alexander Herman, University of Minnesota
@clarazundel.bsky.social
@ryanntansey.bsky.social
November 17, 2025 at 9:18 PM
Here is Week #1 installment for @acnporg.bsky.social Travel Awardees of #ACNP2026
Dr. Mia Rough, Wake Forest University
Dr. Clara Zundel, Wayne State University
Dr. Ryann Tansey, University of Calgary
Dr. Alexander Herman, University of Minnesota
@clarazundel.bsky.social
@ryanntansey.bsky.social
Dr. Mia Rough, Wake Forest University
Dr. Clara Zundel, Wayne State University
Dr. Ryann Tansey, University of Calgary
Dr. Alexander Herman, University of Minnesota
@clarazundel.bsky.social
@ryanntansey.bsky.social
Check back each week to see a new group of
@acnporg.bsky.social Travel Awardees featured and learn all about them & their work - and don't forget to say hello to them at #ACNP2026 👋
@acnporg.bsky.social Travel Awardees featured and learn all about them & their work - and don't forget to say hello to them at #ACNP2026 👋
a man in a white suit with the words our future is bright
ALT: a man in a white suit with the words our future is bright
media.tenor.com
November 17, 2025 at 9:18 PM
Check back each week to see a new group of
@acnporg.bsky.social Travel Awardees featured and learn all about them & their work - and don't forget to say hello to them at #ACNP2026 👋
@acnporg.bsky.social Travel Awardees featured and learn all about them & their work - and don't forget to say hello to them at #ACNP2026 👋