Dr Mark Nixon
@nixon-lab.bsky.social
Research Fellow at Centre for Cardiovascular Science, University of Edinburgh. Investigating glucocorticoid action in cardiometabolic disease. Views my own
Website:
http://www.edinburghmetabolism.co.uk/mark-nixon
ORCID: 0000-0001-5437-3724
Website:
http://www.edinburghmetabolism.co.uk/mark-nixon
ORCID: 0000-0001-5437-3724
Even more exciting to see our lab’s work in the spotlight - huge congratulations to Dr Mhairi Paul for delivering an excellent poster presentation and adding yet another award to her growing collection! 👏🥂
Looking forward to the rest of the conference!
Looking forward to the rest of the conference!
March 11, 2025 at 10:27 AM
Even more exciting to see our lab’s work in the spotlight - huge congratulations to Dr Mhairi Paul for delivering an excellent poster presentation and adding yet another award to her growing collection! 👏🥂
Looking forward to the rest of the conference!
Looking forward to the rest of the conference!
A big thank you to the organisers and funders, including @thebhf.bsky.social and @physoc.bsky.social for putting together such a great event. Already looking forward to next year in Glasgow!
February 23, 2025 at 9:41 AM
A big thank you to the organisers and funders, including @thebhf.bsky.social and @physoc.bsky.social for putting together such a great event. Already looking forward to next year in Glasgow!
A huge well done to Mahnoor Asif, Doanne Chin and Mhairi Paul for presenting their work— all did a brilliant job representing our lab. And an extra congratulations to Mhairi Paul for winning the Best Poster Presentation award! A well-deserved recognition of her hard work and dedication.
February 23, 2025 at 9:41 AM
A huge well done to Mahnoor Asif, Doanne Chin and Mhairi Paul for presenting their work— all did a brilliant job representing our lab. And an extra congratulations to Mhairi Paul for winning the Best Poster Presentation award! A well-deserved recognition of her hard work and dedication.
We're really excited to share this research exploring the unique CV risk of men and women when it comes to obesity-induced vascular dysfunction.
Huge credit to ✨ Lisa Ivatt as this was her main PhD work, but also to the co-authors & colleagues who helped guide this from concept to publication.
Huge credit to ✨ Lisa Ivatt as this was her main PhD work, but also to the co-authors & colleagues who helped guide this from concept to publication.
January 27, 2025 at 1:25 PM
We're really excited to share this research exploring the unique CV risk of men and women when it comes to obesity-induced vascular dysfunction.
Huge credit to ✨ Lisa Ivatt as this was her main PhD work, but also to the co-authors & colleagues who helped guide this from concept to publication.
Huge credit to ✨ Lisa Ivatt as this was her main PhD work, but also to the co-authors & colleagues who helped guide this from concept to publication.
💡 Take home messages:
➡️ In mesenteric PVAT (mPVAT), obesity induces unique upregulation of ECM pathways in male, but not female mice.
➡️ In contrast to insulin sensitivity, the relative protection of female mice from obesity-induced mPVAT dysregulation is not mediated by ovarian hormones
➡️ In mesenteric PVAT (mPVAT), obesity induces unique upregulation of ECM pathways in male, but not female mice.
➡️ In contrast to insulin sensitivity, the relative protection of female mice from obesity-induced mPVAT dysregulation is not mediated by ovarian hormones
January 27, 2025 at 1:25 PM
💡 Take home messages:
➡️ In mesenteric PVAT (mPVAT), obesity induces unique upregulation of ECM pathways in male, but not female mice.
➡️ In contrast to insulin sensitivity, the relative protection of female mice from obesity-induced mPVAT dysregulation is not mediated by ovarian hormones
➡️ In mesenteric PVAT (mPVAT), obesity induces unique upregulation of ECM pathways in male, but not female mice.
➡️ In contrast to insulin sensitivity, the relative protection of female mice from obesity-induced mPVAT dysregulation is not mediated by ovarian hormones
For the first time in mice, we have investigated how anatomically different perivascular adipose tissue (PVAT) respond to high-fat diet, using omics approaches to assess their transcriptional signatures. In parallel, we analysed the impact of PVAT changes on vascular function.
January 27, 2025 at 1:25 PM
For the first time in mice, we have investigated how anatomically different perivascular adipose tissue (PVAT) respond to high-fat diet, using omics approaches to assess their transcriptional signatures. In parallel, we analysed the impact of PVAT changes on vascular function.
There are many people to thank within the Centre for Cardiovascular Science @EdinburghUniversity and our wonderful collaborators @UniversityofBritishColumbia, but in particular I must thank the participants and our funders @thebhf.bsky.social and @wellcometrust.bsky.social
January 10, 2025 at 2:27 PM
There are many people to thank within the Centre for Cardiovascular Science @EdinburghUniversity and our wonderful collaborators @UniversityofBritishColumbia, but in particular I must thank the participants and our funders @thebhf.bsky.social and @wellcometrust.bsky.social
In brief:
🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG
🚚Increased NE in obese adipose facilitates local GC delivery
🐭🚶♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes
🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG
🚚Increased NE in obese adipose facilitates local GC delivery
🐭🚶♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes
January 10, 2025 at 2:27 PM
In brief:
🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG
🚚Increased NE in obese adipose facilitates local GC delivery
🐭🚶♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes
🎯Neutrophil Elastase (NE) regulates glucocorticoid (GC) bioavailability through cleavage of CBG
🚚Increased NE in obese adipose facilitates local GC delivery
🐭🚶♂️NE manipulation in mice/humans impacts adipose GC exposure, linking obesity and inflammation to cardiometabolic outcomes