Nina Donner, PhD
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ninadonner.bsky.social
Nina Donner, PhD
@ninadonner.bsky.social
27 followers 19 following 1 posts
About me:
Science Communicator, Project Manager, Researcher, Nature Lover

Position at concentris research management gmbh:
Empowering European science and innovation with

#GrantWriting
#ProjectManagement
#ScienceCommunication
#Dissemination
Posts Replies Media Videos
Reposted by Nina Donner, PhD
microb-predict.bsky.social
On Wednesday, 26 Nov, at 6 pm CET, EASL Studio hosts a new episode titled “Rifaximin for Hepatic Encephalopathy: Balancing Benefits and Risks in the Era of Antimicrobial Resistance”

The episode will be broadcast live on EASL.eu and can be accessed here:

📹 easl.eu/easl-studio-...

Don't miss it ☺️
November 24, 2025 at 12:05 PM
Reposted by Nina Donner, PhD
microb-predict.bsky.social
🎉 Our new #mirobiome paper in #JHEP is out! We found distinct gut #virome shifts in #ACLF - from virulent to temperate #phages - with Lactococcus A + Enterococcus B phages linked to infections & higher 90-day mortality

👉 Read more: www.sciencedirect.com/science/arti...

📽️Video: youtu.be/0YF6qToBQUM
October 24, 2025 at 11:33 AM
Reposted by Nina Donner, PhD
microb-predict.bsky.social
🌍 The MICROB-PREDICT team met in Münster, Germany from 1–2 October for its 14th Steering Committee Meeting!

👉 Team leaders discussed results from 20 new papers about late-stage #LiverDisease #cirrhosis #biomarkers and IPR topics as the project nears its final phase.

The finish line is in sight!
October 24, 2025 at 11:18 AM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
20% live with #ChronicPain - many without effective treatment

The QSPainRelief database uses published data, existing meds & advanced models to help design more effective therapies

🎥 Intro video: youtu.be/0VWoc2fqks8
🔗 Database: qspainrelief.lacdr.leidenuniv.nl

#PainRelief #PersonalisedMedicine
Introduction to the QSPainRelief Database (by Daan van Valkengoed, Leiden University, NL)
YouTube video by concentris research management
youtu.be
September 20, 2025 at 4:28 PM
Reposted by Nina Donner, PhD
a-tango.bsky.social
👏 1st Site Visit Completed for A-TANGO's #ClinicalTrial: Thanks to big efforts by Yaqrit + Royal Free Hospital, we have kicked off our Phase 2a trial, evaluating the safety of #TLR4 antagonist in combination with #G-CSF for the treatment of #ACLF!

#BenchToBedside #cirrhosis
@rajivjalan.bsky.social
October 4, 2025 at 5:03 AM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
✨Final spotlight of this series: Our open access protocol on a self-medication #MouseModel of #ChronicPain that helps assess spontaneous #PainRelief & #DrugAbuse liability

🔗 doi.org/10.21769/Bio...
Cabañero et al. (2022), co-authored by Beltrán Álvarez & Rafael Maldonado

#Neuroscience #Analgesics
October 3, 2025 at 6:59 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
youtu.be/nIpZY5Msaec?...
Food addiction vulnerability in mice and humans and miRNA signatures
YouTube video by Journal of Clinical Investigation
youtu.be
October 3, 2025 at 6:30 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
5️⃣ García-Blanco et al. (2002): www.jci.org/articles/vie...
📖 miRNA signatures associated with vulnerability to food addiction in mice & humans

💡Common #miRNA #signatures in mice & humans may underlie vulnerability to #FoodAddiction.
💡Targeting those miRNAs may modify maladaptive eating phenotypes.
JCI - miRNA signatures associated with vulnerability to food addiction in mice and humans
www.jci.org
October 3, 2025 at 6:27 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
4️⃣ academic.oup.com/ismej/articl...
📖 Presence of #Blastocystis in #GutMicrobiota associated with decreased executive function

💡Blastocystis colonisation in the gut is associated with measurable deficits in executive #CognitiveFunction, suggesting a possible #GutBrainAxis influence on cognition.
Presence of Blastocystis in gut microbiota is associated with cognitive traits and decreased executive function
AbstractGrowing evidence implicates the gut microbiome in cognition. Blastocystis is a common gut single-cell eukaryote parasite frequently detected in hum
academic.oup.com
October 3, 2025 at 6:22 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
3️⃣ doi.org/10.3389/fpsy...
📖 Tetrahydrocannabinol #THC exposure in #adolescence elevates #impulsivity-like behaviour in #adulthood in a self-administration mouse model

💡Young-age THC exposure may produce a lasting impulsivity increase & neurochemical changes that predispose to #AddictiveBehaviour.
Frontiers | THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model
Cannabis addiction is a chronically relapsing disorder lacking effective treatment. Regular cannabis consumption typically begins during adolescence, and thi...
doi.org
October 3, 2025 at 6:18 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
2️⃣García-Blanco et al., 2023 www.sciencedirect.com/science/arti...
📖 #CB2 #CannabinoidReceptor & the development of food addiction in mice

💡CB2R is a modulatory node in the control of hedonic feeding and vulnerability to #FoodAddiction, making it a potential therapeutic target for eating disorders
Role of CB2 cannabinoid receptor in the development of food addiction in male mice
The endocannabinoid system plays an important role in multiple behavioral responses due to its wide distribution in the central nervous system. The ca…
www.sciencedirect.com
October 3, 2025 at 6:12 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
1️⃣ Del Mar Cajiao-Manrique, Maldonado & Martín-García (2023) doi.org/10.3389/fpha...
📖 A self-administration mouse model to study #CannabinoidAddiction

💡This novel #MouseModel provides a rigorous tool to study #CannabinoidAddiction & the neurobiological mechanisms of #vulnerability vs. #resilience.
Frontiers | A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction
We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212-2 intravenous self-administration (0.0125 mg/kg/infusion) in C...
doi.org
October 3, 2025 at 6:04 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
🧬🐭👩‍🦰👨‍🦰 Translational research - from mice to humans - was central to #QSPainRelief: For better #PainRelief, safer #PainMedication and improved #ChronicPain treatment.

✅ Less pain
😵‍💫 Fewer side effects
☺️ Better QoL

✨ Here are 5 key papers about 🧠-mechanisms linked to #addiction #cognition #impulsivity
October 3, 2025 at 6:02 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
A more #PainRelief-relevant follow-up of the 2020 Sci. Rep. paper is this article by Ricarte, Dalton & Giraldo (2021), a year later:

🔗 doi.org/10.1021/acs....

🧬 Structural assessment of #agonist #efficacy at the μ-opioid receptor #MOR

👉 #morphine and #fentanyl elicit different activation patterns
October 3, 2025 at 4:21 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
🔬 Wanna know the P-values for #agonist-dependent #GPCR activation?

👏 One of our 2 high-impact Nature publications was also the 1st QSPainRelief article:

📈 Bruzzese, Dalton & Giraldo (2020) present their #MolecularDynamics work & the best statistics to analyse it.

🔗 www.nature.com/articles/s41...
October 3, 2025 at 4:07 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
Here's another important QSPainRelief publication about allosteric sites at #GPCRs: They can be identified by looking at how strongly certain receptor sites are coupled to #conformational changes that occur during activation.

🔗 doi.org/10.3390/ijms...

#allostery #pharmacology #receptors #ligands
October 3, 2025 at 3:31 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
Speaking of #allostery: What happens when you mutate the #CannabinoidReceptor (CB1) in silico with a single-point mutation?

Find out👉: doi.org/10.1021/acso...

Spoiler😉: The F237L mutation mimics #allosteric #ligand effects, globally altering #receptor conformations and hindering activation

#GPCR
October 3, 2025 at 1:31 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
🎯Feature Alert 🚨
This paper delves into how #BindingKinetics reshape our understanding of #allosteric modulation. When it comes to cooperativity effects, it's all about

👉 WHERE molecules bind
👉 HOW FAST
👉 and in WHICH SEQUENCE

🔗 doi.org/10.1016/j.dr...

#allostery #pharmacology #DrugDesign #GPCRs
October 3, 2025 at 1:22 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
🚀 Time-dependent #ligand-receptor #BindingKinetics and functionality in a #heterodimeric receptor model by Ortiz et al. (2024): Predicting how 2 drugs bind to a receptor complex over time - with implications for combination-therapies and #DrugDesign💊

🔗 doi.org/10.1016/j.bc...

#Pharmacology #GPCRs
October 3, 2025 at 12:29 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
🔦 Spotlight on link.springer.com/article/10.1...

🧠 Using the LeiCNS-PK3.0 PBPK model, they predicted mouse #brainECF #pharmacokinetics for 10 drugs

✅ Accurate for 7 drugs
✅ First mechanistic #CNS PBPK #model in mice
✅ Strong translational potential

#TranslationalPharmacology #DrugDevelopment
October 3, 2025 at 12:13 PM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
The paper by Budda et al. (2024) relates to the earlier publication by Gülave et al. (2023): doi.org/10.1016/j.ej...

🧠The transport of #morphine across the #BBB is non-linear - this is important for #receptor #occupancy predictions. Find out how BBB dynamics inform smarter, safer dosing strategies!
October 3, 2025 at 11:19 AM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
🧠 Non-linear blood-brain barrier #BBB transport & dosing influence #receptor #occupancy ratios of #morphine and #MorphineMetabolites (M3G + M6G) in the #pain matrix.

💡This might also explain some inter-individual differences!

🔗 bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
#ChronicPain #opioids
October 3, 2025 at 11:08 AM
Reposted by Nina Donner, PhD
qspainrelief.bsky.social
🔬By Bertayli et al (2024): PK-PD modelling of #morphine, #pregabalin & their combination shows synergistic #analgesia.

Potential impact:

👉 Lowering #opioid doses
👉 Maintaining treatment efficacy
👉 Reducing side effects & abuse liability

🔗 www.page-meeting.org/default.asp?...

#ChronicPain #Pain
October 3, 2025 at 10:21 AM