Nicole Moss
@nicoledmoss.bsky.social
RNA, development + evolution enthusiast | Nichols Lab Postdoc at CU Anschutz | Alumni of Silver Lab, Sussel Lab, University of Oregon + OIMB, TFA Connecticut
nicholslab.org | nicoledmoss.weebly.com
nicholslab.org | nicoledmoss.weebly.com
Reposted by Nicole Moss
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
A quadratic paradigm describes the relationship between phenotype severity and variation - Nature Communications
Phenotype variation is higher in mutants than wild types. Examining a range of mutant severities, this study unexpectedly found that variation decreases in severe conditions. A quadratic trend best fi...
www.nature.com
October 15, 2025 at 9:24 AM
Lots of great discussion about developmental variability here at #GastrulationReloaded! Super important to consider, and current tools have the power for this.
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Related to this recent paper showing that mild phenotypes are more variable than severe ones. www.nature.com/articles/s41...
Reposted by Nicole Moss
Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
September 17, 2025 at 5:30 PM
Out today. 🙏 again to everyone for this wonderful piece of work, in particular to Aurelie @aurhin.bsky.social Chase @chasebolt.bsky.social and Brent @homeobox.bsky.social. 🙏 also to the Harris lab @fish4walking.bsky.social and @neilshubin.bsky.social @biology-unige.bsky.social @college-de-france.fr
Reposted by Nicole Moss
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
August 10, 2025 at 1:19 PM
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
Reposted by Nicole Moss
This preprint is now out after peer review! Check it out: www.cell.com/cell-genomic.... Huge congrats (and thanks!) to the whole team that contributed!
May 21, 2025 at 6:34 PM
This preprint is now out after peer review! Check it out: www.cell.com/cell-genomic.... Huge congrats (and thanks!) to the whole team that contributed!
Reposted by Nicole Moss
Cross-posting from LinkedIn: www.linkedin.com/posts/kevin-...
These are useful (and free!) websites that I found in my search for all things #zebrafish as part of my Bioinformatics Bootcamp. If there’s enough interest, I may do a blog post on the Node. Enjoy!
These are useful (and free!) websites that I found in my search for all things #zebrafish as part of my Bioinformatics Bootcamp. If there’s enough interest, I may do a blog post on the Node. Enjoy!
#zebrafish | Kevin Thiessen, Ph.D.
A while back, I put together a Bioinformatics Bootcamp for #zebrafish researchers. Here are some of the helpful links & resources that I've come across in my search:
Disclaimer: This is not a...
www.linkedin.com
May 17, 2025 at 2:51 PM
Cross-posting from LinkedIn: www.linkedin.com/posts/kevin-...
These are useful (and free!) websites that I found in my search for all things #zebrafish as part of my Bioinformatics Bootcamp. If there’s enough interest, I may do a blog post on the Node. Enjoy!
These are useful (and free!) websites that I found in my search for all things #zebrafish as part of my Bioinformatics Bootcamp. If there’s enough interest, I may do a blog post on the Node. Enjoy!
Reposted by Nicole Moss
Taking a snippet of genetic code that is unique to humans and inserting it into mice helps them grow bigger brains than usual
https://go.nature.com/3GOTQkz
https://go.nature.com/3GOTQkz
Mice grow bigger brains when given this stretch of human DNA
Finding adds to the bigger picture of how humans developed such large brains.
go.nature.com
May 14, 2025 at 3:41 PM
Taking a snippet of genetic code that is unique to humans and inserting it into mice helps them grow bigger brains than usual
https://go.nature.com/3GOTQkz
https://go.nature.com/3GOTQkz
Reposted by Nicole Moss
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Excited to see this collection in print! www.sciencedirect.com/special-issu...
Check out our most recent review from the Silver Lab - "How our brains are built: emerging approaches to understand human-specific features".
Check out our most recent review from the Silver Lab - "How our brains are built: emerging approaches to understand human-specific features".
March 2, 2025 at 4:19 PM
Excited to see this collection in print! www.sciencedirect.com/special-issu...
Check out our most recent review from the Silver Lab - "How our brains are built: emerging approaches to understand human-specific features".
Check out our most recent review from the Silver Lab - "How our brains are built: emerging approaches to understand human-specific features".