Join us as the first PhD student in my group! Based in the beautiful city of Münster, Germany, you will develop the chemo-enzymatic synthesis of modified nucleotides, which are used as building blocks of mRNA.
Here is the link:
stellen.uni-muenster.de/jobposting/6...

#chemsky #chembio

We systematically studied the substrate preferences of EbPPK2, determined the first crystal structure of the enzyme and used structure-guided engineering to enable efficient access to base-modified GTP and ATP analogues. #ChemSky #ChemBio

pubs.rsc.org/en/content/a...

Holidays with the family in and around Lisbon, where I lived for eight years 🎉🎉🎉

With chimeric cofactors, we can turn methyltransferases into prenyltransferases. Methyltransferases even prefer AdoPrenyl!Thanks to co-first author Arne and the team led by Andrea
@rentmeisterlab.bsky.social #ChemSky #ChemBio
Read the full story in CHEM www.cell.com/chem/fulltex...

In July, I published my first paper on the chemo-enzymatic generation of base-modified ATP analogues! These can then be used to generate hypermodified poly(A) tails. Thanks to all the people involved!
pubs.rsc.org/en/content/a...

W2-Professur für Molekulare Biochemie an der Uni Münster!
Bewerbung bis zum 15.03.2024
www.uni-muenster.de/Rektorat/Ste...

Hi Bluesky,
over the last years I was working on the biocatalytic generation of SAM analogues to expand the scope of methyltransferases. Selective 4-chlorobenzylation on the mRNA 5′ cap could improve protein production in human cell lines.
doi.org/10.1039/D3SC...