Nature Metabolism, Published online: 04 August 2025; doi:10.1038/s42255-025-01322-wMetabolic reprogramming is a well-established hallmark of macrophage activation, coordinating bioenergetic and biosynthetic pathways to support immune effector functions. A new study now reveals a previously unappreciated, system-wide remodelling of nucleotide metabolism driven by nitric oxide (NO), with important implications for inflammatory macrophage function and host–pathogen interactions.

Nature Metabolism, Published online: 04 August 2025; doi:10.1038/s42255-025-01337-3John et al. show that upon classical activation, macrophages undergo nitric oxide-driven reprogramming of nucleotide metabolism, which affects immune functions and responses.

The Morgridge Institute for Research, in partnership with the Department of Biomolecular Chemistry at the University of Wisconsin-Madison, seeks a joint tenure track assistant professor to lead a vibr...