Monica Elena Neugebauer
@neugmonicaelena.bsky.social
Assistant Professor at UW-Madison I http://mneugebauergroup.biochem.wisc.edu
Reposted by Monica Elena Neugebauer
Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr...
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Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling
Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...
chemrxiv.org
August 28, 2025 at 7:04 PM
Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr...
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Reposted by Monica Elena Neugebauer
Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
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New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
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DNA-Scaffolded Ultrahigh-Throughput Reaction Screening
Discovering and optimizing reactions is central to synthetic chemistry. However, chemical reactions are traditionally screened using relatively low-throughput methods, prohibiting exploration of diver...
chemrxiv.org
August 14, 2025 at 5:40 PM
Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
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New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
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Reposted by Monica Elena Neugebauer
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini
Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...
rdcu.be
July 18, 2025 at 2:40 PM
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
Reposted by Monica Elena Neugebauer
STAND UP FOR SCIENCE SPEAKER ANNOUNCEMENT! ☀️
Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!
More speaker announcements coming soon, stay tuned! 👀☀️
Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!
More speaker announcements coming soon, stay tuned! 👀☀️
March 6, 2025 at 12:00 AM
STAND UP FOR SCIENCE SPEAKER ANNOUNCEMENT! ☀️
Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!
More speaker announcements coming soon, stay tuned! 👀☀️
Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th!
More speaker announcements coming soon, stay tuned! 👀☀️
Reposted by Monica Elena Neugebauer
Finally, in these tough times for science I want to emphasize how this work was supported at every level by NIH: through grants to my lab (DP2); to my students (BTP T32; CBI T32); and from Rohith’s experience as an NIH Postbac in the Tjandra lab. Grateful for the support that made this possible.
March 4, 2025 at 4:28 PM
Finally, in these tough times for science I want to emphasize how this work was supported at every level by NIH: through grants to my lab (DP2); to my students (BTP T32; CBI T32); and from Rohith’s experience as an NIH Postbac in the Tjandra lab. Grateful for the support that made this possible.
Reposted by Monica Elena Neugebauer
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
February 12, 2025 at 4:20 PM
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5