Nele Quast
@nele-q.bsky.social
Deep learning for Biologics @ Oxford Protein Informatics Group
As always, a huge thanks go to @mraybould.bsky.social and Charlotte Deane, as well as the the rest of @opig.stats.ox.ac.uk for the support and platform to do impactful research.
December 17, 2025 at 11:49 AM
As always, a huge thanks go to @mraybould.bsky.social and Charlotte Deane, as well as the the rest of @opig.stats.ox.ac.uk for the support and platform to do impactful research.
The protocol we used to develop and evaluate our structural hypothesis is described in detail in the methods, and we published the computational tool used to analyse and score TCR-antigen complexes in Bioinformatics earlier this year.
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
STCRpy: a software suite for T-cell receptor structure parsing, interaction profiling, and machine learning dataset preparation
AbstractSummary. Computational methods to guide early-stage TCR drug discovery and TCR repertoire informatics currently under-utilize solved and predicted
doi.org
December 17, 2025 at 11:49 AM
The protocol we used to develop and evaluate our structural hypothesis is described in detail in the methods, and we published the computational tool used to analyse and score TCR-antigen complexes in Bioinformatics earlier this year.
doi.org/10.1093/bioi...
doi.org/10.1093/bioi...
This was a test whether the ML methods we develop can be used to explain molecular interactions when we have the experimental data. We used a hybrid deep-learning and physics-simulation approach to identify a structural hypothesis for the specific binding of the KRAS G12V antigen by the TCR.
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December 17, 2025 at 11:49 AM
This was a test whether the ML methods we develop can be used to explain molecular interactions when we have the experimental data. We used a hybrid deep-learning and physics-simulation approach to identify a structural hypothesis for the specific binding of the KRAS G12V antigen by the TCR.
We are looking forward to community contributions as more TCR structure research is conducted. We have also written some developer guidelines; if you have any questions just reach out!
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May 1, 2025 at 1:26 PM
We are looking forward to community contributions as more TCR structure research is conducted. We have also written some developer guidelines; if you have any questions just reach out!
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Big thanks to my supervisors Charlotte Deane and @mraybould.bsky.social for their supervision creating STCRpy. And all @opig.stats.ox.ac.uk for being such a fab group to be part of!
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May 1, 2025 at 1:26 PM
Big thanks to my supervisors Charlotte Deane and @mraybould.bsky.social for their supervision creating STCRpy. And all @opig.stats.ox.ac.uk for being such a fab group to be part of!
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