Nele Quast
@nele-q.bsky.social
Deep learning for Biologics @ Oxford Protein Informatics Group
I'm really pleased that our collaboration with Shira Sagie, Tomer Babu and Yardena Samuels has been published in Cell Reports Medicine. This has been a really fun and productive collaboration as well as an incredible learning process.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation
Sagie et al. identify a KRAS.G12V-specific TCR and show that lymphodepleting chemotherapy
enhances antigen presentation via immunoproteasome activation and HLA-I upregulation.
Together, these changes ...
www.cell.com
December 17, 2025 at 11:49 AM
I'm really pleased that our collaboration with Shira Sagie, Tomer Babu and Yardena Samuels has been published in Cell Reports Medicine. This has been a really fun and productive collaboration as well as an incredible learning process.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
STCRpy, an easy-to-use python package for T-cell receptor structures has just been published in Bioinformatics! Big thanks to @mraybould.bsky.social and Charlotte Deane for their support, and to @opig.stats.ox.ac.uk for being an amazing collaborative group!
Paper: doi.org/10.1093/bioi...
Paper: doi.org/10.1093/bioi...
STCRpy: a software suite for T-cell receptor structure parsing, interaction profiling, and machine learning dataset preparation
AbstractSummary. Computational methods to guide early-stage TCR drug discovery and TCR repertoire informatics currently under-utilize solved and predicted
doi.org
October 31, 2025 at 10:17 AM
STCRpy, an easy-to-use python package for T-cell receptor structures has just been published in Bioinformatics! Big thanks to @mraybould.bsky.social and Charlotte Deane for their support, and to @opig.stats.ox.ac.uk for being an amazing collaborative group!
Paper: doi.org/10.1093/bioi...
Paper: doi.org/10.1093/bioi...
We won the Boltz Hackathon Challenge improving computational efficiency! Big thanks to Boltz team and @merckgroup.bsky.social for the event and very proud of our prototype Boltz Flow Matching model. Huge thanks to Niklas Abraham and Aaron Schöne for being excellent collaborators! ms.spr.ly/6043tBeAL
www.merckgroup.com
October 29, 2025 at 3:47 PM
We won the Boltz Hackathon Challenge improving computational efficiency! Big thanks to Boltz team and @merckgroup.bsky.social for the event and very proud of our prototype Boltz Flow Matching model. Huge thanks to Niklas Abraham and Aaron Schöne for being excellent collaborators! ms.spr.ly/6043tBeAL
Do you wish working with T-cell receptor structures was easier?
Us too!
STCRpy, our software suite for T cell receptor structure parsing, interaction profiling and machine learning dataset preparation is now available!
Github: github.com/npqst/stcrpy/
Pre-print: www.biorxiv.org/content/10.1...
1/3
Us too!
STCRpy, our software suite for T cell receptor structure parsing, interaction profiling and machine learning dataset preparation is now available!
Github: github.com/npqst/stcrpy/
Pre-print: www.biorxiv.org/content/10.1...
1/3
GitHub - npqst/STCRpy
Contribute to npqst/STCRpy development by creating an account on GitHub.
github.com
May 1, 2025 at 1:26 PM
Do you wish working with T-cell receptor structures was easier?
Us too!
STCRpy, our software suite for T cell receptor structure parsing, interaction profiling and machine learning dataset preparation is now available!
Github: github.com/npqst/stcrpy/
Pre-print: www.biorxiv.org/content/10.1...
1/3
Us too!
STCRpy, our software suite for T cell receptor structure parsing, interaction profiling and machine learning dataset preparation is now available!
Github: github.com/npqst/stcrpy/
Pre-print: www.biorxiv.org/content/10.1...
1/3
Reposted by Nele Quast
Applications are now open for UNIQ+ @ox.ac.uk (deadline Wed 19 February 2025)!
We're delighted to be offering a project on Nanobody Language Modelling. Learn about deep learning and language modelling and gain experience applying these methods to nanobody sequences
www.ox.ac.uk/admissions/g...
We're delighted to be offering a project on Nanobody Language Modelling. Learn about deep learning and language modelling and gain experience applying these methods to nanobody sequences
www.ox.ac.uk/admissions/g...
UNIQ+ | University of Oxford
UNIQ+ Research Internships are aimed at talented undergraduates from under-represented groups, who would find continuing into postgraduate study a challenge for reasons other than their academic
www.ox.ac.uk
January 20, 2025 at 3:28 PM
Applications are now open for UNIQ+ @ox.ac.uk (deadline Wed 19 February 2025)!
We're delighted to be offering a project on Nanobody Language Modelling. Learn about deep learning and language modelling and gain experience applying these methods to nanobody sequences
www.ox.ac.uk/admissions/g...
We're delighted to be offering a project on Nanobody Language Modelling. Learn about deep learning and language modelling and gain experience applying these methods to nanobody sequences
www.ox.ac.uk/admissions/g...
Reposted by Nele Quast
OPIG is now on Bluesky!
Follow us for updates about the group's latest work, web app updates, and more.
opig.stats.ox.ac.uk
Follow us for updates about the group's latest work, web app updates, and more.
opig.stats.ox.ac.uk
OPIG
Oxford Protein Informatics Group
opig.stats.ox.ac.uk
January 15, 2025 at 1:53 PM
OPIG is now on Bluesky!
Follow us for updates about the group's latest work, web app updates, and more.
opig.stats.ox.ac.uk
Follow us for updates about the group's latest work, web app updates, and more.
opig.stats.ox.ac.uk