Noah Eckman
neckman.bsky.social
Noah Eckman
@neckman.bsky.social
Hydrogels, immunotherapy, and rheology in the Appel Group at Stanford. engineer/musician/humanist. bluesky-ing from both sides of my brain.
It turns out... yes! Cell viabilities were significantly lower for gels with stronger crosslinks (but the same stiffness!) (6/8)
March 2, 2025 at 11:25 PM
We calculated a "yielding speed" which correlated nicely with the crosslink strength. (4/8)
March 2, 2025 at 11:25 PM
We used techniques to extract data about the speed of the yielding transition from rheological measurements. From these, we could see that the less dynamic materials have a more brittle, or sudden transition, versus a more smooth one. (3/8)
March 2, 2025 at 11:25 PM
Dynamic hydrogels allow flexible delivery of cells, due to the ability of crosslinks to break and re-form. We analyzed three clinically relevant, dynamic gels with similar stiffness to see how changing crosslink dynamics would change the physics of the yielding transition (2/8)
March 2, 2025 at 11:25 PM