Precision Functional Mapping (PFM). 8 yrs ago some told us it wasn't interesting. Now it's helping cure depression as part of PACE (Personalized Adaptive Cortical Electro-stimulation), ... commercialized by @turingmedical.bsky.social.

osf.io/preprints/ps...
www.cell.com/neuron/comme...

American Academy of Neurology podcast about the AMN: www.neurology.org/media/podcas...

17-years after first stumbling upon this network, there’s finally sufficient evidence to functionally annotate it as AMN, using an inside-out approach, starting with a brain entity and asking what it might be doing … instead of reifying a psychological concept into the brain.

While the AMN’s effect on behavior is directly visible to evolutionary selection, the default-mode’s restorative offline processes must of course also increase fitness, indirectly.

A map of the AMN’s anti-correlations (functional connectivity) almost perfectly captures the DMN, highlighting the push-pull relationship between the action and default modes.

The AMN has been commonly confused & conflated with other higher-order networks, most often with Seeley et al.’s Salience network. AMN and Salience are anatomically and functionally distinct. Don’t mix ‘em up. Don’t lump ‘em together!

Landmark 2011 functional connectivity articles by Yeo et al and Power et al both identified the AMN despite distinct methods and datasets but had different names for it.

The AMN was identified with functional connectivity & task fMRI and initially named the cingulo-opercular network (CON) based on anatomy, even though it’s more widely distributed.

The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️

If you're making participants do something specific, you probably don't need brain data, since the effect is through the correlation between behaviors. Another benefit of structural and resting-state is that you don't have to collect a new data set each time. & it's easier.