Nature Reviews Endocrinology, Published online: 08 August 2025; doi:10.1038/s41574-025-01166-0Imaging has a growing role in the evaluation of obesity-related disorders and the effects of weight loss, especially given the increasing use of glucagon-like peptide 1 agonists. New imaging biomarkers are emerging. Artificial intelligence applications for automated quantification of body composition underline future capabilities of whole-body MRI to comprehensively assess patients with obesity.

Nature Reviews Cardiology, Published online: 25 November 2025; doi:10.1038/s41569-025-01237-9In this Comment, I propose an outcome-oriented classification of heart failure based on skeletal muscle mass. By distinguishing between heart failure with either preserved or reduced muscle mass, this conceptual framework represents a major step towards abandoning the misleading concept of the ‘obesity–mortality paradox’ in cardiology.

Nature Reviews Endocrinology, Published online: 01 May 2025; doi:10.1038/s41574-025-01120-0Body mass index (BMI), as its name indicates, is a marker of total body mass and not a specific marker of adipose tissue mass. Here, we position relative fat mass (RFM) as an ideal alternative to BMI by highlighting the superior performance of RFM in assessing cardiometabolic risk.

Relative fat mass (RFM) is a novel sex-specific anthropometric equation (based on height and waist measurements) to estimate whole-body fat percentage…

AbstractAim. To examine sex differences in associations of obesity, type-2 diabetes, hypertension, and atrial fibrillation (AF) with incident cardiovascula

Background We evaluated the potential of circulating bone morphogenetic protein 10 (BMP10) as a biomarker for atrial stress and remodelling in patients with heart failure (HF), in comparison to N-term...