@nathusky.bsky.social
Reposted
Important 🇦🇺 study for #IDSky regarding ECMO infections in 11 pts
-Cannula colonization very common with viable 🦠🧫
-Rarely correlate with bacteremia (our work supports most BSI don’t come from cannulas)
Why this matters: leads to hyperinflammatory state and makes traditional markers 🤒🔬unreliable.
-Cannula colonization very common with viable 🦠🧫
-Rarely correlate with bacteremia (our work supports most BSI don’t come from cannulas)
Why this matters: leads to hyperinflammatory state and makes traditional markers 🤒🔬unreliable.
Characterization of microbial growths on peripheral cannulas in #ECMO
🩸 only 1 patient presented with matching positive blood + cannula cultures (same organism) + signs of bacteremia: colonization, rather than infection, more common in clinical practice
🖇️ bit.ly/3EMq3bw
🩸 only 1 patient presented with matching positive blood + cannula cultures (same organism) + signs of bacteremia: colonization, rather than infection, more common in clinical practice
🖇️ bit.ly/3EMq3bw
Characterization of microbial growths on peripherally inserted cannulas during #ECMO
🔬 clinical biofilms formed on cannula surfaces in patients on #ECLS have diverse morphological characteristics
🧫 ⅓ of cannula exit sites + peripheral cannula sections colonized
🖇️ bit.ly/3EMq3bw
🔬 clinical biofilms formed on cannula surfaces in patients on #ECLS have diverse morphological characteristics
🧫 ⅓ of cannula exit sites + peripheral cannula sections colonized
🖇️ bit.ly/3EMq3bw
May 4, 2025 at 1:17 AM
Important 🇦🇺 study for #IDSky regarding ECMO infections in 11 pts
-Cannula colonization very common with viable 🦠🧫
-Rarely correlate with bacteremia (our work supports most BSI don’t come from cannulas)
Why this matters: leads to hyperinflammatory state and makes traditional markers 🤒🔬unreliable.
-Cannula colonization very common with viable 🦠🧫
-Rarely correlate with bacteremia (our work supports most BSI don’t come from cannulas)
Why this matters: leads to hyperinflammatory state and makes traditional markers 🤒🔬unreliable.
Reposted
Improved Survival in Vascular Pythiosis with Surgery and Azithromycin, Doxycycline, and Itraconazole Therapy: A Phase II Multicenter, Open-Label, Single-Arm Trial
✅ Just Accepted
✅ Just Accepted
Improved Survival in Vascular Pythiosis with Surgery and Azithromycin, Doxycycline, and Itraconazole Therapy: A Phase II Multicenter, Open-Label, Single-Arm Trial
Vascular pythiosis, caused by Pythium insidiosum, is a life-threatening disease with high mortality rate in patients with residual disease post-surgery. This study evaluated the effectiveness of a combination therapy of surgery, azithromycin, doxycycline, and itraconazole.
buff.ly
February 13, 2025 at 7:58 PM
Improved Survival in Vascular Pythiosis with Surgery and Azithromycin, Doxycycline, and Itraconazole Therapy: A Phase II Multicenter, Open-Label, Single-Arm Trial
✅ Just Accepted
✅ Just Accepted
Reposted
Big Data Bayesian Truths: No Vancomycin Trough Concentration Target is Sufficiently Precise for Safety or Efficacy
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Big Data Bayesian Truths: No Vancomycin Trough Concentration Target is Sufficiently Precise for Safety or Efficacy
Therapeutic drug monitoring is standard of care for vancomycin because of the known efficacy and safety exposure window [i.e. area under the concentration-time curve (AUC) of 400-600 mg*24hours/L]. Despite guideline recommendations, AUCs are infrequently calculated because of the perceived adequacy of trough (Cmin) concentrations.
buff.ly
February 12, 2025 at 12:55 AM
Big Data Bayesian Truths: No Vancomycin Trough Concentration Target is Sufficiently Precise for Safety or Efficacy
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky