Nathan Lewis
@natelewis3.bsky.social
GRA Eminent Scholar and Professor at University of Georgia. Into Systems Biology, genome editing, cell-cell interactions, glycobiology, metabolism, biologics, and lots of other cool science stuff. Http://lewis.uga.edu
Looking forward to this collaboration with Ginkgo www.genengnews.com/topics/biopr...
Ginkgo Bioworks Awarded Project Agreement Through BARDA's BioMaP-Consortium
The goal of the project is to develop novel approaches that strengthen and reduce the costs of domestic mAb biomanufacturing to protect against and treat infection by filoviruses.
www.genengnews.com
November 6, 2025 at 4:42 PM
Looking forward to this collaboration with Ginkgo www.genengnews.com/topics/biopr...
Reposted by Nathan Lewis
Monty Python understood p-hacking
October 23, 2025 at 8:43 AM
Monty Python understood p-hacking
😭
October 23, 2025 at 3:07 PM
😭
I love this visual of what I've been telling my kids / students, but I add that immediate answers rob our creativity too. I regularly ask myself "i can prompt this, but how important will my struggle be here?" Some tasks are perfect for AI. For others I choose to stimulate creativity & learning.
In my talks this wk, I placed my notion of the importance of drawing badly to find unexpected connections alongside my Ai statement - we need that struggle, to make mistakes in order to be surprised - it’s the decisions along the way that make us who we are and there is no shortcut to getting there…
October 18, 2025 at 12:35 PM
I love this visual of what I've been telling my kids / students, but I add that immediate answers rob our creativity too. I regularly ask myself "i can prompt this, but how important will my struggle be here?" Some tasks are perfect for AI. For others I choose to stimulate creativity & learning.
Why do some recomb proteins express better than others? After expressing >2000 proteins from the human secretome in CHO cells, we identified the protein features and host cell pathways linked to poor expression w/ @JohanRockberg lab. www.pnas.org/doi/abs/10.1...
October 14, 2025 at 2:57 AM
Why do some recomb proteins express better than others? After expressing >2000 proteins from the human secretome in CHO cells, we identified the protein features and host cell pathways linked to poor expression w/ @JohanRockberg lab. www.pnas.org/doi/abs/10.1...
Robert Francis Kennedy Junior
In honor of spooky month, share a 4 word horror story that only someone in your profession would understand:
The colony has parvovirus.
The colony has parvovirus.
Grant scored over payline
October 12, 2025 at 8:11 PM
Robert Francis Kennedy Junior
Reposted by Nathan Lewis
The team at BioF:GREAT is always on the lookout for new protein design models that care about more than just the backbone! We are excited to try the new RFdiffusion3 (RFD3)! 🚀 New preprint from David Baker!🚀 🧪 #ProteinDesign #DeepLearning #ComputationalBiology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
De novo Design of All-atom Biomolecular Interactions with RFdiffusion3
Deep learning has accelerated protein design, but most existing methods are restricted to generating protein backbone coordinates and often neglect interactions with other biomolecules. We present RFd...
www.biorxiv.org
September 19, 2025 at 3:15 PM
The team at BioF:GREAT is always on the lookout for new protein design models that care about more than just the backbone! We are excited to try the new RFdiffusion3 (RFD3)! 🚀 New preprint from David Baker!🚀 🧪 #ProteinDesign #DeepLearning #ComputationalBiology
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Honored to have our recent work on mapping out the cell machinery regulating protein secretion highlighted at GEN www.genengnews.com/topics/biopr...
Mapping Out the “Everything” of Protein Secretion
The invention of CRISPR and DNA sequencing has provided the necessary tools for rapidly engineering CHO cells along with a parts list.
www.genengnews.com
August 22, 2025 at 9:14 AM
Honored to have our recent work on mapping out the cell machinery regulating protein secretion highlighted at GEN www.genengnews.com/topics/biopr...
Excitng collaboration in which we expressed a hepatitis c vaccine candidate in a panel of glycoengineered CHO cell lines. This allowed us to find a specific glycan structure that greatly improved immunogenecity, even for more distant strains #glycotime www.nature.com/articles/s41...
Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity - npj Vaccines
npj Vaccines - Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity
www.nature.com
June 11, 2025 at 7:27 PM
Excitng collaboration in which we expressed a hepatitis c vaccine candidate in a panel of glycoengineered CHO cell lines. This allowed us to find a specific glycan structure that greatly improved immunogenecity, even for more distant strains #glycotime www.nature.com/articles/s41...
While our first discovery of this occurred just weeks into the shutdown, it's great to see it off bioRxiv now.
SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others #glycotime
journals.asm.org/doi/10.1128/...
SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others #glycotime
journals.asm.org/doi/10.1128/...
SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx | mBio
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible
for coronavirus disease 2019, can infect the gastrointestinal (GI) tract, and individuals
who exhibit GI symptoms of...
journals.asm.org
March 12, 2025 at 9:54 PM
While our first discovery of this occurred just weeks into the shutdown, it's great to see it off bioRxiv now.
SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others #glycotime
journals.asm.org/doi/10.1128/...
SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. Great collab with Knight and Esko labs and many others #glycotime
journals.asm.org/doi/10.1128/...
Took me a while to get the new uga address, but my lab website is finally live. lewislab.uga.edu
February 3, 2025 at 4:22 AM
Took me a while to get the new uga address, but my lab website is finally live. lewislab.uga.edu
With all of the US government science chaos going on, I'm curious if anyone knows which governments are seeing the great opportunity to recruit top labs and tech companies, to bolster their international presence, and to reverse the brain drain.
February 3, 2025 at 4:09 AM
With all of the US government science chaos going on, I'm curious if anyone knows which governments are seeing the great opportunity to recruit top labs and tech companies, to bolster their international presence, and to reverse the brain drain.
Reposted by Nathan Lewis
🚨 Join us for the next GlyGen Webinar!
🗓 Feb 4, 2025 | 🕒 10 AM EST
🎙️ Speaker: Dr. Parastoo Azadi, CCRC, @universityofga.bsky.social
💡 Research, Collaboration, Service & Training at CCRC
📑 Details: wiki.glygen.org
Also, don't miss our Jan webinar on Jan 28th!
#glycotime
🗓 Feb 4, 2025 | 🕒 10 AM EST
🎙️ Speaker: Dr. Parastoo Azadi, CCRC, @universityofga.bsky.social
💡 Research, Collaboration, Service & Training at CCRC
📑 Details: wiki.glygen.org
Also, don't miss our Jan webinar on Jan 28th!
#glycotime
January 22, 2025 at 12:01 AM
🚨 Join us for the next GlyGen Webinar!
🗓 Feb 4, 2025 | 🕒 10 AM EST
🎙️ Speaker: Dr. Parastoo Azadi, CCRC, @universityofga.bsky.social
💡 Research, Collaboration, Service & Training at CCRC
📑 Details: wiki.glygen.org
Also, don't miss our Jan webinar on Jan 28th!
#glycotime
🗓 Feb 4, 2025 | 🕒 10 AM EST
🎙️ Speaker: Dr. Parastoo Azadi, CCRC, @universityofga.bsky.social
💡 Research, Collaboration, Service & Training at CCRC
📑 Details: wiki.glygen.org
Also, don't miss our Jan webinar on Jan 28th!
#glycotime
Reposted by Nathan Lewis
After ~8 years, happy to share work done w/
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!
www.nature.com/articles/s42...
#science #biotech #cancermetabolism
Thread below:
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!
www.nature.com/articles/s42...
#science #biotech #cancermetabolism
Thread below:
Multiplex genome editing eliminates lactate production without impacting growth rate in mammalian cells - Nature Metabolism
Hefzi et al. engineer cells to nearly eliminate lactate production and increase mitochondrial use of pyruvate by deleting both lactate dehydrogenases and pyruvate dehydrogenase kinases with the goal o...
www.nature.com
January 20, 2025 at 9:41 AM
After ~8 years, happy to share work done w/
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!
www.nature.com/articles/s42...
#science #biotech #cancermetabolism
Thread below:
@natelewis3.bsky.social showing you can eliminate the Warburg effect in mammalian cells w/out impacting growth rate is out now in @natmetabolism.bsky.social!
www.nature.com/articles/s42...
#science #biotech #cancermetabolism
Thread below:
I don't think that 101 years ago, Otto Warburg was aware how broadly relevant his discovery was. Check out our new paper out today in Nature Metabolism, wherein we engineered the Warburg effect out of mammalian cells to improve biologics production urldefense.com/v3/__https:/...
January 14, 2025 at 3:05 PM
I don't think that 101 years ago, Otto Warburg was aware how broadly relevant his discovery was. Check out our new paper out today in Nature Metabolism, wherein we engineered the Warburg effect out of mammalian cells to improve biologics production urldefense.com/v3/__https:/...
Reposted by Nathan Lewis
Calling all glyco-enthusiasts!! We have an opening for a tenure-track faculty member at any rank in the Complex Carbohydrate Research Center (ccrc.uga.edu) in the areas of plant or microbial glycoscience. Come join our amazing team.
#glycotime
www.ugajobsearch.com/postings/400...
#glycotime
www.ugajobsearch.com/postings/400...
a cartoon of a pitcher with a spoon and a cup of sugar on a table
ALT: a cartoon of a pitcher with a spoon and a cup of sugar on a table
media.tenor.com
November 21, 2024 at 8:11 PM
Calling all glyco-enthusiasts!! We have an opening for a tenure-track faculty member at any rank in the Complex Carbohydrate Research Center (ccrc.uga.edu) in the areas of plant or microbial glycoscience. Come join our amazing team.
#glycotime
www.ugajobsearch.com/postings/400...
#glycotime
www.ugajobsearch.com/postings/400...
These past few years have seen a rapid expansion of cell-cell communication research. Check out our new review of the diverse methods leveraging single-cell and spatial omics: rdcu.be/dwkND
January 20, 2024 at 3:45 PM
These past few years have seen a rapid expansion of cell-cell communication research. Check out our new review of the diverse methods leveraging single-cell and spatial omics: rdcu.be/dwkND