If it only live for 12-24 hours, how we can call it senescence?

Learn most of proteomics knowledge from MaxQuant training videos on YouTube

Welcome!

DDM may not the best to make bubbles, but definitely the best to get your peptide off from the tubes

The main idea behind this is to use transcript reference mapping to assign the cell types, and then do proteomics DE analysis to avoid the double dipping. So external single cell databases also take into considerations

thanks for post it!

I have more questions on Figure 4. Seems IonQuant and Maxquant can not give correct estimates of spike-in protein abundance. I am not sure if it is a normalization issue or FDR control issue.

It is a great/beautiful study to push the low input proteomics to clinical space. I do agree the title is misleading, it should name as “single cell type proteomics” or “cell type specific proteomics”

Congratulations @proteomicsnews.bsky.social, can not wait to see more exciting single cell studies from your lab

As I moved my focus to more scientific questions, I prefer to have less identification, better quantification, and more trustworthy data. It is super expensive to validate each proteins for downstream study

Cool

I will try to get him here

Such a tool is in great need. Will dig into this paper! Thanks for sharing