Maxence Nachury
@nachury.bsky.social
We study cilia, with a focus on trafficking of signaling molecules and ciliopathies. #cilia
nachurylab.ucsf.edu
nachurylab.ucsf.edu
Stellar presentation. Can't wait to see the preprint/paper. Kudos to @alanbrownhms.bsky.social and @sven-m-lange.bsky.social for taking an unbiased biuochemcial approach to interogate ubiquitin reading by the ciliary transport machienry.
April 22, 2025 at 6:33 PM
Stellar presentation. Can't wait to see the preprint/paper. Kudos to @alanbrownhms.bsky.social and @sven-m-lange.bsky.social for taking an unbiased biuochemcial approach to interogate ubiquitin reading by the ciliary transport machienry.
Reposted by Maxence Nachury
We close: a fan fave PTM #ubiquitin- roles in ciliary cargo retrieval by #IFT machinery as it remodels at the #cilia/ #flagellar tip, open questions re dynamics across time & space- preprint to drop soon... Amazing @sven-m-lange.bsky.social (@alanbrownhms.bsky.social lab, Harvard) #UKCilia2025 5/7
April 22, 2025 at 5:08 PM
We close: a fan fave PTM #ubiquitin- roles in ciliary cargo retrieval by #IFT machinery as it remodels at the #cilia/ #flagellar tip, open questions re dynamics across time & space- preprint to drop soon... Amazing @sven-m-lange.bsky.social (@alanbrownhms.bsky.social lab, Harvard) #UKCilia2025 5/7
Reposted by Maxence Nachury
Second (takes deep breath)
It appears that PAYMENTS FOR ALL GRANTS THROUGH THE PAYMENT MANAGEMENT SYSTEM ARE BEING FROZEN.
If this is correct, then no funds will be transferred to any grantee institution, at least at this time.
It appears that PAYMENTS FOR ALL GRANTS THROUGH THE PAYMENT MANAGEMENT SYSTEM ARE BEING FROZEN.
If this is correct, then no funds will be transferred to any grantee institution, at least at this time.
a cartoon of a chicken with its mouth open and a drop of blood coming out of it
ALT: a cartoon of a chicken with its mouth open and a drop of blood coming out of it
media.tenor.com
April 18, 2025 at 8:51 PM
Second (takes deep breath)
It appears that PAYMENTS FOR ALL GRANTS THROUGH THE PAYMENT MANAGEMENT SYSTEM ARE BEING FROZEN.
If this is correct, then no funds will be transferred to any grantee institution, at least at this time.
It appears that PAYMENTS FOR ALL GRANTS THROUGH THE PAYMENT MANAGEMENT SYSTEM ARE BEING FROZEN.
If this is correct, then no funds will be transferred to any grantee institution, at least at this time.
Congrats! Well deserved
March 28, 2025 at 7:38 PM
Congrats! Well deserved
Very cool paper! It would have been even cooler if they had looked at the role of Dennd1b in regulating Rab35 activity and MC4R trafficking in cilia! See
doi.org/10.15252/emb...
doi.org/10.15252/emb...
Rab35 controls cilium length, function and membrane composition | EMBO reports
image image Rab35 at the mammalian and zebrafish cilium regulates cilium length and left‐right asymmetry, and controls the ciliary levels of PI(4,5)P2 and regulators of the Sonic hedgehog pathway. Rab35 GTPase localizes to the ciliary ...
doi.org
March 6, 2025 at 9:06 PM
Very cool paper! It would have been even cooler if they had looked at the role of Dennd1b in regulating Rab35 activity and MC4R trafficking in cilia! See
doi.org/10.15252/emb...
doi.org/10.15252/emb...
Compounding the issue is that this sloppiness does not get caught during peer review.
March 6, 2025 at 2:50 AM
Compounding the issue is that this sloppiness does not get caught during peer review.
Reposted by Maxence Nachury
It is important for scientists to be as self-critical as possible.
I always try to say "This is a really exciting result. Why is it wrong?".
It's hard but pays off in the long run, both for me and for science.
But, you are right that postdocs and others on the job market are in a tough spot.
I always try to say "This is a really exciting result. Why is it wrong?".
It's hard but pays off in the long run, both for me and for science.
But, you are right that postdocs and others on the job market are in a tough spot.
March 5, 2025 at 10:43 PM
It is important for scientists to be as self-critical as possible.
I always try to say "This is a really exciting result. Why is it wrong?".
It's hard but pays off in the long run, both for me and for science.
But, you are right that postdocs and others on the job market are in a tough spot.
I always try to say "This is a really exciting result. Why is it wrong?".
It's hard but pays off in the long run, both for me and for science.
But, you are right that postdocs and others on the job market are in a tough spot.
Reposted by Maxence Nachury
My personal view is that the biggest issues are investigators fooling themselves, not misconduct or intentional fraud and publication bias (e.g. an experiment "works" once and gets published but fails other times and these results are explained away.
con'ted
con'ted
March 5, 2025 at 10:41 PM
My personal view is that the biggest issues are investigators fooling themselves, not misconduct or intentional fraud and publication bias (e.g. an experiment "works" once and gets published but fails other times and these results are explained away.
con'ted
con'ted