Maxence Nachury
@nachury.bsky.social
We study cilia, with a focus on trafficking of signaling molecules and ciliopathies. #cilia
nachurylab.ucsf.edu
nachurylab.ucsf.edu
Thank you @nytimes.com for helping me crystallize my thoughts on the current administration. Yep, most definitely UNCONVENTIONAL
March 4, 2025 at 10:52 PM
Thank you @nytimes.com for helping me crystallize my thoughts on the current administration. Yep, most definitely UNCONVENTIONAL
Very intersting read. Slides 19 and 20 have the important pieces.
February 8, 2025 at 2:27 AM
Very intersting read. Slides 19 and 20 have the important pieces.
Turns out that MC4R constitutively enters and exit cilia, the latter thanks to a high tonic coupling to ß-arrestin. MC4R levels go up by >10-fold when we block its tonic activation (+AgRP), or when we block exit from cilia (Arl6-/-) or when we delete ß-arrestin (Barr1-/-/Barr2-/-).
February 6, 2025 at 7:40 PM
Turns out that MC4R constitutively enters and exit cilia, the latter thanks to a high tonic coupling to ß-arrestin. MC4R levels go up by >10-fold when we block its tonic activation (+AgRP), or when we block exit from cilia (Arl6-/-) or when we delete ß-arrestin (Barr1-/-/Barr2-/-).
New paper! journals.plos.org/plosbiology/...
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.
February 6, 2025 at 7:40 PM
New paper! journals.plos.org/plosbiology/...
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.
Postdoc extraordinaire @ireneon.bsky.social got to the bottom of a particularly vexing conundrum: The GPCR melanocortin receptor 4 (MC4R) is barely detectable in cilia, yet its localization to cilia is absolutely critical to body weight homeostasis.
Turns out that MC4R constitutively enters and exit cilia, the latter thanks to a high tonic coupling to ß-arrestin. MC4R levels go up by >10-fold when we block its tonic activation (+AgRP), or when we block exit from cilia (Arl6-/-) or when we delete ß-arrestin (Barr1-/-/Barr2-/-).
February 6, 2025 at 7:31 PM
Turns out that MC4R constitutively enters and exit cilia, the latter thanks to a high tonic coupling to ß-arrestin. MC4R levels go up by >10-fold when we block its tonic activation (+AgRP), or when we block exit from cilia (Arl6-/-) or when we delete ß-arrestin (Barr1-/-/Barr2-/-).