Michele Zanini
mzaniniphysiology.bsky.social
Michele Zanini
@mzaniniphysiology.bsky.social
Lecturer in Applied Exercise Science @ The Open University
PhD @ Loughborough University
Head of S&C and Physiologist @ Italian Triathlon Federation
Applied Physiology, Endurance, Performance
7/7

This highlights the importance of training specificity (i.e. long runs) and higher mileage for sustaining economy during prolonged exercise – key for events from 10k to marathon.

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📄 Free full text (AoP): journals.lww.com/acsm-msse/ab...
Regular Long Runs and Higher Training Volumes are... : Medicine & Science in Sports & Exercise
rences in RE durability. Therefore, this study aimed to compare RE durability during a 90 min run and the decrements in neuromuscular capabilities, between athletes that did, or did not, practice regu...
journals.lww.com
August 29, 2025 at 5:21 PM
6/7

Take-home messages:

Even with identical performance levels, training matters for durability.

Runners regularly including long runs – and accumulating higher mileage – had:

✅ More durable running economy
✅ Smaller neuromuscular declines
August 29, 2025 at 5:21 PM
5/7

When we merged data from both groups, RE durability correlated:

📉 strongly to weekly longest run (r=-0.67; p<0.001)

📉 and moderately to weekly running distance (r=-0.48; p=0.038)

But not to declines in neuromuscular function.
August 29, 2025 at 5:21 PM
4/7

Neuromuscular function followed a similar trend:

🦵🏼 SDT showed larger drops in maximal squat force (-19% vs -12%)

⬆️ SDT lost CMJ performance (6.6%), while LDT maintained it
August 29, 2025 at 5:21 PM
3/7

During a 90 min run at LT:

- Running economy deteriorated nearly 50% less in LDT than SDT (+3.1% vs +6.0%)

- Differences emerged after 60min and grew with time
August 29, 2025 at 5:21 PM
2/7

We matched well-trained runners for 10k time (39 min), V̇O₂max (~58 ml/kg/min) & LT speed (12-13 km/h)

But differed in training characteristics:
- LDT: regularly running ≥90min
- SDT: always run <70min

LDT also ran more (51 vs 30 km/wk) & had better fresh running economy
August 29, 2025 at 5:21 PM
5/5

❗️Final message

Researchers should consider, quantify, and report TL.

If you’re assessing training interventions, matching TL may help ensuring results reflect their effect, without being confounded by unintended differences in the dose of training prescribed.
June 24, 2025 at 8:19 AM
4/5

We also highlight why TL matching might not be essential. For instance when:

- Studying real-world training programmes

- Investigating outcomes less sensitive to dose (like enjoyment or adherence).
June 24, 2025 at 8:19 AM
3/5

Our paper explores how TL mismatches can skew results, and when matching TL is likely beneficial.

We provide 3 practical examples in areas where TL warrants consideration.

And briefly discuss how an increased TL carries differences depending on participants characteristics
June 24, 2025 at 8:19 AM
2/5

Training load (TL) can be associated to the "dose" of exercise.

When groups in a study receive different doses, it becomes unclear whether the outcomes are due to the type of training, or simply more training.

An issue for interpreting effectiveness in some contexts.
June 24, 2025 at 8:19 AM
8/8

‼️Results matter for durability studies assessing interventions & longitudinal athlete profiling.

🔑 Finding: Even subtle differences in RE durability between conditions are likely detectable.

🔁 Share if you find this interesting.

🆓 Open access
📄 onlinelibrary.wiley.com/doi/10.1111/...
Test–Retest Reliability of Running Economy and Other Physiological Parameters During 90 min of Running in Well‐Trained Male Endurance Runners
Running economy (RE) is highly reliable when measured in an unfatigued state; however, its reproducibility during prolonged exercise has not been investigated. RE is known to worsen during prolonged ...
onlinelibrary.wiley.com
May 27, 2025 at 12:40 PM
7/8

Summary:

✅ RE (expressed as OC or EC) is reliable during prolonged running
✅ VE, RER, and HR also consistent
⚠️ BLa and RPE less so, esp. >60 min

4/5 PhD studies published. As always thanks to Rich Blagrove and Jonathan Folland.
May 27, 2025 at 12:40 PM
6/8

Blood lactate (BLa) was the least reliable:

🔹 ICC = 0.48–0.94
🔹 CV = 5–16%

Reliability dropped after 60 min.

This likely reflects limits in analyser precision more than physiology.
Caution warranted when interpreting small BLa changes during prolonged exercise!
May 27, 2025 at 12:40 PM
5/8

RPE was moderately reliable, with:

🔹 ICCs = 0.41–0.72
🔹 CV = 4.2–6.0%
No effect of time on CV – fatigue didn’t make it less reliable.

Important: subjectivity means RPE isn’t as stable as physiological data.
May 27, 2025 at 12:40 PM
4/8

Heart rate (HR) was also highly reliable:

🔹 ICCs = 0.82–0.92
🔹 CV = ~1.1%
🔻 Slightly lower in trial 2 at later timepoints; possibly due to familiarisation.

Still well within typical day-to-day HR variability.
May 27, 2025 at 12:40 PM
3/8

Ventilation (VE) and RER also showed strong reliability:

🔹 VE: ICC = 0.96–0.97, CV < 3.6%
🔹 RER: ICC = 0.78, TE ≤ 1.9%

These markers are consistent across 90 min of heavy-intensity running.
May 27, 2025 at 12:40 PM
2/8

Both Energy Cost (EC) and Oxygen Cost (OC) showed excellent reliability across all timepoints:

✅ ICCs: 0.96–0.99
✅ CVs: 0.6%–1.2%
✅ TE: ≤1.4%

No decline in reliability over time.

‼️RE durability is measurable and trustworthy.
May 27, 2025 at 12:40 PM
I think a possible solution could be having a testing session as an outdoor long run with pre-post assessment of running economy and speed at LT (this could be done on a separate day).

sLT is likely to capture multiple changes under a single variable, and testing it may not be too intense.
May 21, 2025 at 2:29 PM
Thank you Jamie!

I think a thorough durability testing for high-level marathon is quite challenging - as you already pointed out. Athletes more trained than our cohort will likely display smaller changes, so either duration or intensity would need to increase..
May 21, 2025 at 2:29 PM