Masataka Yanagawa
@myanagawa.bsky.social
Associate Prof., Tohoku Univ. Single-molecule biophysics, Pharmacology, GPCR, RTK, TRP, Signaling
Pinned
Excited to share our latest paper in @natchembio.nature.com revealing how β-arrestins compartmentalize active GPCRs through multivalent PIP2 binding! We identified a non-canonical PIP2-binding site that drives GPCR-βarr clustering in PIP2-rich membrane domains. www.nature.com/articles/s41...
Membrane-domain compartmentalization of active GPCRs by β-arrestins through PtdIns(4,5)P2 binding - Nature Chemical Biology
A newly identified phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-binding site reveals multivalent interactions between β-arrestins (βarrs) and PtdIns(4,5)P2 that facilitate G-protein-coupled r...
www.nature.com
August 6, 2025 at 2:07 PM
Excited to share our latest paper in @natchembio.nature.com revealing how β-arrestins compartmentalize active GPCRs through multivalent PIP2 binding! We identified a non-canonical PIP2-binding site that drives GPCR-βarr clustering in PIP2-rich membrane domains. www.nature.com/articles/s41...
Thrilled to see our work published in @nchembio! Huge congratulations to Fumiya, Kota, Kazuhiro, and the incredible team🎉
“Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R”
www.nature.com/articles/s41...
“Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R”
www.nature.com/articles/s41...
Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R - Nature Chemical Biology
Description of the cryo-EM structures of the parathyroid hormone type 1 receptor associated with Gq reveals two distinct extracellular conformations with N-glycans stabilizing a ligand-tilted conforma...
www.nature.com
June 26, 2025 at 1:18 PM
Thrilled to see our work published in @nchembio! Huge congratulations to Fumiya, Kota, Kazuhiro, and the incredible team🎉
“Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R”
www.nature.com/articles/s41...
“Insights into G-protein coupling preference from cryo-EM structures of Gq-bound PTH1R”
www.nature.com/articles/s41...