Mugridge Lab
@mugridgelab.bsky.social
News feed for the Mugridge Lab in the Department of Chemistry & Biochemistry @UDelaware. We study the structural and biochemical mechanisms that control RNA modification and function in the cell.
PI: @jeffmugridge.bsky.social
web: mugridgelab.org
PI: @jeffmugridge.bsky.social
web: mugridgelab.org
Congrats to Angel on the final version of her TRMT1 / SARS-CoV-2 Mpro story, now published in eLife! Her work reveals the structural basis for how #SARS-CoV-2 impacts #tRNA modifications! #RNAsky #RNAbiology
📣 Final version of our @elife.bsky.social article is now online! We show how the human tRNA methyltransferase TRMT1 is recognized, cleaved, and inactivated by the SARS-CoV-2 main protease to disrupt host tRNA modification!
elifesciences.org/articles/91168
A short bluetorial... 🧵 1/9
elifesciences.org/articles/91168
A short bluetorial... 🧵 1/9
Recognition and cleavage of human tRNA methyltransferase TRMT1 by the SARS-CoV-2 main protease
The SARS-CoV-2 main protease specifically cleaves a conserved sequence in the human tRNA modifying enzyme TRMT1, resulting in reduced tRNA binding and the complete loss of TRMT1-mediated tRNA methyltr...
elifesciences.org
January 16, 2025 at 1:08 PM
Congrats to Angel on the final version of her TRMT1 / SARS-CoV-2 Mpro story, now published in eLife! Her work reveals the structural basis for how #SARS-CoV-2 impacts #tRNA modifications! #RNAsky #RNAbiology
Big milestones - this year we said goodbye to the first two PhD grads from our lab! Now Drs. Angel D'Oliviera and Evan Geissler!👩🎓👨🎓 🎉
We also started a new lab tradition - PhD swords! ⚔️ Pictured is Angel's engraved sword with her Mpro-TRMT1 structure!
We also started a new lab tradition - PhD swords! ⚔️ Pictured is Angel's engraved sword with her Mpro-TRMT1 structure!
January 6, 2025 at 4:32 PM
Big milestones - this year we said goodbye to the first two PhD grads from our lab! Now Drs. Angel D'Oliviera and Evan Geissler!👩🎓👨🎓 🎉
We also started a new lab tradition - PhD swords! ⚔️ Pictured is Angel's engraved sword with her Mpro-TRMT1 structure!
We also started a new lab tradition - PhD swords! ⚔️ Pictured is Angel's engraved sword with her Mpro-TRMT1 structure!
We've now migrated our lab news feed from X/twitter to Bluesky using @blueark.app! Content that could be migrated from X/twitter are all below this post; original posting dates appear as tags on the expanded posts.
January 6, 2025 at 4:04 PM
We've now migrated our lab news feed from X/twitter to Bluesky using @blueark.app! Content that could be migrated from X/twitter are all below this post; original posting dates appear as tags on the expanded posts.
This week we said farewell to our amazing undergrad Sophie Olson! Sophie did fantastic work in our lab and is graduating with a BS in Biochemistry! Congrats!🎉 Next up, Sophie will be killing it in the Molecular, Cellular, & Integrative Biosciences PhD program @PennState!
January 4, 2025 at 9:40 PM
This week we said farewell to our amazing undergrad Sophie Olson! Sophie did fantastic work in our lab and is graduating with a BS in Biochemistry! Congrats!🎉 Next up, Sophie will be killing it in the Molecular, Cellular, & Integrative Biosciences PhD program @PennState!
Congrats to lab members Celeste and Youmna, who both recently passed their PhD qualifying exams! 🎉👩🔬
January 4, 2025 at 9:40 PM
Congrats to lab members Celeste and Youmna, who both recently passed their PhD qualifying exams! 🎉👩🔬
We finally got out and celebrated our lab's recent NSF CAREER award today with a lab bowling and laser tag trip! Pew pew! 🔫🎳
January 4, 2025 at 9:40 PM
We finally got out and celebrated our lab's recent NSF CAREER award today with a lab bowling and laser tag trip! Pew pew! 🔫🎳
Very excited that the @NSF CAREER will fund our lab's projects studying mechanisms of really cool tRNA-modifying metalloenzymes starting this year! Huge thanks to Evan & Youmna who got awesome preliminary data for this proposal! We hope to share work from these projects soon! 😀
January 4, 2025 at 9:40 PM
Very excited that the @NSF CAREER will fund our lab's projects studying mechanisms of really cool tRNA-modifying metalloenzymes starting this year! Huge thanks to Evan & Youmna who got awesome preliminary data for this proposal! We hope to share work from these projects soon! 😀
Lab trivia night to celebrate the end of the semester!
January 4, 2025 at 9:40 PM
Lab trivia night to celebrate the end of the semester!
Another award for Sophie! Huge congrats to her on winning the Quaesita Drake Scholarship, given to outstanding undergraduate biochemists, at the @ChemistryUD awards colloquium earlier this week! Go Sophie! And congrats to all the other amazing undergrads who won awards!
January 4, 2025 at 9:40 PM
Another award for Sophie! Huge congrats to her on winning the Quaesita Drake Scholarship, given to outstanding undergraduate biochemists, at the @ChemistryUD awards colloquium earlier this week! Go Sophie! And congrats to all the other amazing undergrads who won awards!
Our rockstar undergrad Sophie Olson took home the 2nd place biochemistry prize for her awesome research talk at the 86th annual ISCC conference recently hosted at @LVC. Way to go Sophie!
January 4, 2025 at 9:40 PM
Our rockstar undergrad Sophie Olson took home the 2nd place biochemistry prize for her awesome research talk at the 86th annual ISCC conference recently hosted at @LVC. Way to go Sophie!
Cheers to Kasun @thxhungryhippo on rocking his candidacy exam earlier today! We celebrated with some morning mimosas! 🍾🍊
January 4, 2025 at 9:40 PM
Cheers to Kasun @thxhungryhippo on rocking his candidacy exam earlier today! We celebrated with some morning mimosas! 🍾🍊
Congratulations to Kasun @thxhungryhippo from our lab for winning a @ChemistryUD Dyer award for excellence in teaching! 🎉🧑🏫 Congrats to the other Dyer award winners as well for contributing to great teaching and TAing the CBC department!
January 4, 2025 at 9:40 PM
Congratulations to Kasun @thxhungryhippo from our lab for winning a @ChemistryUD Dyer award for excellence in teaching! 🎉🧑🏫 Congrats to the other Dyer award winners as well for contributing to great teaching and TAing the CBC department!
Lab escape room trip! We had two successful escapes!
January 4, 2025 at 9:40 PM
Lab escape room trip! We had two successful escapes!
Celebrating the end of Summer session and great work from undergrads Sophie and Joseph (purple arrows), who just completed their first summer of research, with some UDairy ice cream! (consumed ice cream not pictured)
January 4, 2025 at 9:45 PM
Celebrating the end of Summer session and great work from undergrads Sophie and Joseph (purple arrows), who just completed their first summer of research, with some UDairy ice cream! (consumed ice cream not pictured)
Congrats to @mugridgelab undergrad Sophie Olson, whose Summer research in our lab will be funded by a @ChemistryUD David Plastino Fellowship! Congrats to the other awardees & big thanks to Dave Plastino - we're excited to have Sophie joining us over the Summer!
📷 @BrianBahnson
📷 @BrianBahnson
January 4, 2025 at 9:45 PM
Congrats to @mugridgelab undergrad Sophie Olson, whose Summer research in our lab will be funded by a @ChemistryUD David Plastino Fellowship! Congrats to the other awardees & big thanks to Dave Plastino - we're excited to have Sophie joining us over the Summer!
📷 @BrianBahnson
📷 @BrianBahnson
Congrats to @mugridgelab undergrad Jasmin Bioteau for winning the @ChemistryUD Merck Index Award this year! Way to go Jasmin! Congrats to all the other departmental awardees too!
📷 @lauren_genova
📷 @lauren_genova
January 4, 2025 at 9:45 PM
Congrats to @mugridgelab undergrad Jasmin Bioteau for winning the @ChemistryUD Merck Index Award this year! Way to go Jasmin! Congrats to all the other departmental awardees too!
📷 @lauren_genova
📷 @lauren_genova
A very much needed updated lab photo! We have lots of new group members to welcome who've joined over the past few months... 1/
January 4, 2025 at 9:45 PM
A very much needed updated lab photo! We have lots of new group members to welcome who've joined over the past few months... 1/
Wrapping up a busy semester of candidacy exams in the group! Congrats to Luke!
January 4, 2025 at 9:45 PM
Wrapping up a busy semester of candidacy exams in the group! Congrats to Luke!
🍾Congrats to Brittany! Now all 3 of the lab's first members are officially PhD candidates!
January 4, 2025 at 9:45 PM
🍾Congrats to Brittany! Now all 3 of the lab's first members are officially PhD candidates!
🎉Congratulations to Evan on passing his candidacy exam! We had a chilly but fun celebration!🍾⛄️
January 4, 2025 at 9:45 PM
🎉Congratulations to Evan on passing his candidacy exam! We had a chilly but fun celebration!🍾⛄️
🥳 Congratulations to now-PhD-candidate Angel @biochemistAngel on being the first student from our lab to advance to candidacy! Great work!
January 4, 2025 at 9:45 PM
🥳 Congratulations to now-PhD-candidate Angel @biochemistAngel on being the first student from our lab to advance to candidacy! Great work!
Enjoying the Fall weather with a lab mini-golfing trip!
January 4, 2025 at 9:45 PM
Enjoying the Fall weather with a lab mini-golfing trip!
Lab canoeing trip at Lum's Pond! Great weather and great fun. We missed Evan and Emily, but will get out more soon!
January 4, 2025 at 9:51 PM
Lab canoeing trip at Lum's Pond! Great weather and great fun. We missed Evan and Emily, but will get out more soon!
📣Come do science with us!🧪🧬 We're actively recruiting a POSTDOC and/or RESEARCH TECH on NIH-funded projects to understand the function and structure of RNA-modifying enzymes!
Research Tech job desc:...
Research Tech job desc:...
January 4, 2025 at 9:51 PM
📣Come do science with us!🧪🧬 We're actively recruiting a POSTDOC and/or RESEARCH TECH on NIH-funded projects to understand the function and structure of RNA-modifying enzymes!
Research Tech job desc:...
Research Tech job desc:...