In mESCs autophagy prevents POMP accumulation and nucleolar localization (F). This mechanism is developmentally regulated and lost with differentiation (G). Additionally, POMP nuclear relocalization is observed in a mouse model of Huntington’s disease (H). 🧵4/4

Upon relocalization POMP acquires a new set of interaction partners (D), preserves ribogenesis (E) and drives a protective transcriptional program (F) 🧵3/4

Normally POMP is rapidly degraded during protesome biogenesis (A), but in response to stress it accumulates without a concomitant increase in partner proteasome subunits (B) This stoichiometric uncoupling together with increased ROS leads to its relocalization to the nucleolus (C) 🧵2/4

New Preprint out !

The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
www.biorxiv.org/content/10.1...

Lead by: @sgiando.bsky.social
with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more

Short thread below 🧵1/4

Normally POMP is rapidly degraded during protesome biogenesis (A), but in response to stress it accumulates without a concomitant increase in partner proteasome subunits (B) This stoichiometric uncoupling together with increased ROS leads to its relocalisation to the nucleolus (C) 🧵2/4