Mara Mueller
@muellermara.bsky.social
She/her.
Doctoral researcher at MPI for Brain Research, in the lab of @erin-schuman.bsky.social.
Molecular Neuroscience. RNA biology and ribosomes. Local Translation. CRISPR systems.
Hyped about bioengineering and AI in biology.
Amateur illustrator.
Doctoral researcher at MPI for Brain Research, in the lab of @erin-schuman.bsky.social.
Molecular Neuroscience. RNA biology and ribosomes. Local Translation. CRISPR systems.
Hyped about bioengineering and AI in biology.
Amateur illustrator.
In mESCs autophagy prevents POMP accumulation and nucleolar localization (F). This mechanism is developmentally regulated and lost with differentiation (G). Additionally, POMP nuclear relocalization is observed in a mouse model of Huntington’s disease (H). 🧵4/4
April 28, 2025 at 3:08 PM
In mESCs autophagy prevents POMP accumulation and nucleolar localization (F). This mechanism is developmentally regulated and lost with differentiation (G). Additionally, POMP nuclear relocalization is observed in a mouse model of Huntington’s disease (H). 🧵4/4
Upon relocalization POMP acquires a new set of interaction partners (D), preserves ribogenesis (E) and drives a protective transcriptional program (F) 🧵3/4
April 28, 2025 at 3:08 PM
Upon relocalization POMP acquires a new set of interaction partners (D), preserves ribogenesis (E) and drives a protective transcriptional program (F) 🧵3/4
Normally POMP is rapidly degraded during protesome biogenesis (A), but in response to stress it accumulates without a concomitant increase in partner proteasome subunits (B) This stoichiometric uncoupling together with increased ROS leads to its relocalization to the nucleolus (C) 🧵2/4
April 28, 2025 at 3:08 PM
Normally POMP is rapidly degraded during protesome biogenesis (A), but in response to stress it accumulates without a concomitant increase in partner proteasome subunits (B) This stoichiometric uncoupling together with increased ROS leads to its relocalization to the nucleolus (C) 🧵2/4
Normally POMP is rapidly degraded during protesome biogenesis (A), but in response to stress it accumulates without a concomitant increase in partner proteasome subunits (B) This stoichiometric uncoupling together with increased ROS leads to its relocalisation to the nucleolus (C) 🧵2/4
April 28, 2025 at 2:42 PM
Normally POMP is rapidly degraded during protesome biogenesis (A), but in response to stress it accumulates without a concomitant increase in partner proteasome subunits (B) This stoichiometric uncoupling together with increased ROS leads to its relocalisation to the nucleolus (C) 🧵2/4
Seconding @dpastoors.bsky.social recommendation: I use eLabFTW every day and love it. Open-source, freeware, completely customizable and lets you host everything on your own servers
www.elabftw.net
www.elabftw.net
eLabFTW - Open Source Laboratory Notebook
A free and open source electronic laboratory notebook for experimental research.
www.elabftw.net
December 6, 2023 at 11:22 PM
Seconding @dpastoors.bsky.social recommendation: I use eLabFTW every day and love it. Open-source, freeware, completely customizable and lets you host everything on your own servers
www.elabftw.net
www.elabftw.net