🔄 Fig 6: CHIMERYS enables fair DDA vs DIA comparisons.
→ Same algorithm, consistent FDR
→ IDs vs data completeness: tune your workflow to your needs
Unify your data analysis workflow with #CHIMERYS: choose the mode, not the model!
7/7

💡 Fig 5: CHIMERYS unlocks #directInfusion proteomics (DISPA) — library-free!
→ Up to 3× more IDs result in richer functional insights
→ Same #deepLearning model and data processing as for DDA & DIA
Any mass spec-data, no special tuning, just deeper results.
6/7

📐 Fig 4: CHIMERYS quantifies peptides directly from chimeric #MS2 spectra. How? Deconvolution!
→ #PRM-level precision with r = 0.99 vs Skyline
→ CV performance on par with established DIA algorithms
No libraries. No manual curation. Straight from data to insights.
5/7

🚀 Fig 3: In DIA, complexity skyrockets. No problem for CHIMERYS!
→ CHIMERYS delivers high ID rates with better FDR control than other solutions
→ More informative fragment utilization yields more reliable #quantification
It handles #DIA data in a spectrum-centric fashion.
4/7

📈 Fig 2: Challenging data? CHIMERYS shines!
Extract more IDs from any DDA data — good for revisiting legacy data, even low-res.
→ 4x more throughput without loss in IDs
→ 2x more IDs at the same throughput
→ Cloud-based for speed & scalability
Unveil secrets older data hold!
3/7

🧩 Fig 1: CHIMERYS solves the puzzle of chimeric spectra as mixtures of peptides.
Using AI-based predictions and regularized linear regression, it identifies multiple peptides per MS2 spectrum. With rigorous #FDR control, it outperforms 8 search engines in #DDA ID rates.
2/7