Michael Riedl
@mriedl.bsky.social
Postdoc Brugues Lab at MPI-CBG / TUD
PhD Sixt and Hof Group at ISTA
Engineer in Biophysics
-
Active matter, Cell Biology, Chaos to Order, Synchronization, Emergent Behavior -
Team Toy Science.
PhD Sixt and Hof Group at ISTA
Engineer in Biophysics
-
Active matter, Cell Biology, Chaos to Order, Synchronization, Emergent Behavior -
Team Toy Science.
And when put together this allows us to recreate a phase diagram that neatly recovers the transition between solid liquid and gas phases.
We are currently very excited about this work that is currently under review. Give it a read!
arxiv.org/abs/2409.16734
(6/6)
We are currently very excited about this work that is currently under review. Give it a read!
arxiv.org/abs/2409.16734
(6/6)
November 18, 2024 at 5:14 PM
And when put together this allows us to recreate a phase diagram that neatly recovers the transition between solid liquid and gas phases.
We are currently very excited about this work that is currently under review. Give it a read!
arxiv.org/abs/2409.16734
(6/6)
We are currently very excited about this work that is currently under review. Give it a read!
arxiv.org/abs/2409.16734
(6/6)
Decreasing the number of balls in the system opens up different states.
(5/6)
(5/6)
November 18, 2024 at 5:14 PM
Decreasing the number of balls in the system opens up different states.
(5/6)
(5/6)
Allowing us to show the phase transitions and calculate entropy as well as a temperature for the system. This allows us to identify unstable configurations that appear only for a short time.
(4/6)
(4/6)
November 18, 2024 at 5:14 PM
Allowing us to show the phase transitions and calculate entropy as well as a temperature for the system. This allows us to identify unstable configurations that appear only for a short time.
(4/6)
(4/6)
So we try to assess the entropy of the states and came up with a neat definition taking into account the degrees of freedom utilized by the system. We evaluate those based on the tracks of translation and rotation in all spheres independently.
(3/6)
(3/6)
November 18, 2024 at 5:14 PM
So we try to assess the entropy of the states and came up with a neat definition taking into account the degrees of freedom utilized by the system. We evaluate those based on the tracks of translation and rotation in all spheres independently.
(3/6)
(3/6)
It is not as easy as it should be, we thought the same. However, the system undergoes phase transitions and during those the arrow of time becomes evident again.
(2/6)
(2/6)
November 18, 2024 at 5:14 PM
It is not as easy as it should be, we thought the same. However, the system undergoes phase transitions and during those the arrow of time becomes evident again.
(2/6)
(2/6)
We have an inherent intuition for the progression of time. In entropy producing systems the arrow of time should appear clear and a reversed movie feels thereby wrong. Look at these macroscopic active spheres and try to figure out whether the movie has been reversed.(1/6)
arxiv.org/abs/2409.16734
arxiv.org/abs/2409.16734
November 18, 2024 at 5:14 PM
We have an inherent intuition for the progression of time. In entropy producing systems the arrow of time should appear clear and a reversed movie feels thereby wrong. Look at these macroscopic active spheres and try to figure out whether the movie has been reversed.(1/6)
arxiv.org/abs/2409.16734
arxiv.org/abs/2409.16734
What fascinated me is that the refractory phase of the reaction aligns them in time. Here a time projection. : )
November 15, 2024 at 4:05 PM
What fascinated me is that the refractory phase of the reaction aligns them in time. Here a time projection. : )
And here at last some eye-candy of different polymerization patterns of actin waves.
(12/12)
(12/12)
November 15, 2024 at 9:33 AM
And here at last some eye-candy of different polymerization patterns of actin waves.
(12/12)
(12/12)
While uncooperative individuals within the populations destabilize the ordered state or prevent it from arising in the first place - in both systems – preselecting similar individuals renders the ordered state stable even at high densities.
(11/12)
(11/12)
November 15, 2024 at 9:33 AM
While uncooperative individuals within the populations destabilize the ordered state or prevent it from arising in the first place - in both systems – preselecting similar individuals renders the ordered state stable even at high densities.
(11/12)
(11/12)
Collectively migrating cells move within a confinement In these populations the nucleation frequencies of the polymerizing actin waves is in synch resulting in a uniform speed.
(10/12)
(10/12)
November 15, 2024 at 9:33 AM
Collectively migrating cells move within a confinement In these populations the nucleation frequencies of the polymerizing actin waves is in synch resulting in a uniform speed.
(10/12)
(10/12)
The nucleation frequency of newly emerging waves of polymerizing actin waves positively correlates with the migration speed of cells.
(9/12)
(9/12)
November 15, 2024 at 9:33 AM
The nucleation frequency of newly emerging waves of polymerizing actin waves positively correlates with the migration speed of cells.
(9/12)
(9/12)
But is this true for cells? Is the force generating mechanism also synchronized in cells? To address this, we visualized actin polymerization in our cells and the resulting pictures are a feast for the eye.
(8/12)
(8/12)
November 15, 2024 at 9:33 AM
But is this true for cells? Is the force generating mechanism also synchronized in cells? To address this, we visualized actin polymerization in our cells and the resulting pictures are a feast for the eye.
(8/12)
(8/12)
And by producing balls with transparent half-spheres, we can even see that the synchronization process includes even their driving motors.
(7/12)
(7/12)
November 15, 2024 at 9:33 AM
And by producing balls with transparent half-spheres, we can even see that the synchronization process includes even their driving motors.
(7/12)
(7/12)
To understand the transition between disorder and order, we show that a low number of random selected balls switches between both states. By tracking their shells, we find that their oscillating angular velocity synchronizes.
(6/12)
(6/12)
November 15, 2024 at 9:33 AM
To understand the transition between disorder and order, we show that a low number of random selected balls switches between both states. By tracking their shells, we find that their oscillating angular velocity synchronizes.
(6/12)
(6/12)
Visually, the occurring collective motion is strikingly similar to the rotational motion of cells.
(5/12)
(5/12)
November 15, 2024 at 9:33 AM
Visually, the occurring collective motion is strikingly similar to the rotational motion of cells.
(5/12)
(5/12)
On sufficiently rough substrate, the balls roll around with oscillating speed on unstable trajectories. We got a lot of them and put them together... Wait and see what happens!
(4/12)
(4/12)
November 15, 2024 at 9:33 AM
On sufficiently rough substrate, the balls roll around with oscillating speed on unstable trajectories. We got a lot of them and put them together... Wait and see what happens!
(4/12)
(4/12)
But how do they self-organize? To understand the process better, we came up with a “toy” model of motorized balls – these active spheres driven by an unbalanced motor freely rotating within a spherical shell.
(3/12)
(3/12)
November 15, 2024 at 9:33 AM
But how do they self-organize? To understand the process better, we came up with a “toy” model of motorized balls – these active spheres driven by an unbalanced motor freely rotating within a spherical shell.
(3/12)
(3/12)
When I started this project I was mesmerized that monolayers of endothelial cells transition from a disordered motion to a collective rotational state in micron-sized confinement.
(2/12)
(2/12)
November 15, 2024 at 9:33 AM
When I started this project I was mesmerized that monolayers of endothelial cells transition from a disordered motion to a collective rotational state in micron-sized confinement.
(2/12)
(2/12)
Moving some content to this platform.
"Synchronization in collectively moving inanimate and living active matter" - Combining cell biology with an unconventional toy model, we show that synchronization unifies speeds in a collective. rdcu.be/dl0JF
Here is the story: (1/12)
"Synchronization in collectively moving inanimate and living active matter" - Combining cell biology with an unconventional toy model, we show that synchronization unifies speeds in a collective. rdcu.be/dl0JF
Here is the story: (1/12)
November 15, 2024 at 9:33 AM
Moving some content to this platform.
"Synchronization in collectively moving inanimate and living active matter" - Combining cell biology with an unconventional toy model, we show that synchronization unifies speeds in a collective. rdcu.be/dl0JF
Here is the story: (1/12)
"Synchronization in collectively moving inanimate and living active matter" - Combining cell biology with an unconventional toy model, we show that synchronization unifies speeds in a collective. rdcu.be/dl0JF
Here is the story: (1/12)
Polymerizing actin creates fireworks that are a sight to behold. This excitable medium produces polymerizing waves similar to those observed in other context. The parallels I tried to lay out in this perspective piece last year: tinyurl.com/53cbxm4v
(LifeAct-GFP in Endothelial Cell)
(LifeAct-GFP in Endothelial Cell)
November 14, 2024 at 1:04 PM
Polymerizing actin creates fireworks that are a sight to behold. This excitable medium produces polymerizing waves similar to those observed in other context. The parallels I tried to lay out in this perspective piece last year: tinyurl.com/53cbxm4v
(LifeAct-GFP in Endothelial Cell)
(LifeAct-GFP in Endothelial Cell)