Molecular Biomedicine
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Molecular Biomedicine
@mol-biomed.bsky.social
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Molecular Biomedicine （ESCI） is a peer-reviewed and OA journal launched by Springer Nature in 2020, publishing the pioneer works in molecular medicine.
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Molecular Biomedicine @mol-biomed.bsky.social · Nov 7
Congratulations!👏👏

In the recently released JCR Impact Factor 2024, Molecular Biomedicine received an IF of 10.1, placing it in the 🎉Q1 categories for Medicine, Research & Experimental (18/195), Biochemistry & Molecular Biology (23/319), and Cell Biology (27/204). #JCR2025
mol-biomed.bsky.social
#Researh
#FK506 binding protein 12.6-mediated inhibition of sperm-specific calcineurin is essential for FK506-induced male infertility by disturbing the #homeostasis of #calcium and #mitochondria
doi.org/10.1186/s435...

#MaleiInfertility #FKBP #Calcineurin #CalciumRelease
FK506 binding protein 12.6-mediated inhibition of sperm-specific calcineurin is essential for FK506-induced male infertility by disturbing the homeostasis of calcium and mitochondria - Molecular Biome...
Impaired sperm motility is a leading cause of male infertility. Studies indicated that FK506, an immunosuppressive drug, resulted in male mouse infertility or an overall decline in the fertilization c...
doi.org
December 26, 2025 at 6:24 AM
mol-biomed.bsky.social
#Research
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression doi.org/10.1186/s435...

#NSCLC #ArginineMono_methylation #SOX9 #PRMT7 #R160 #FBXW7 #KEAP1
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression - Molecular Biomedicine
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, underscoring the need for deeper insights into its molecular mechanisms. The SRY-box transcription fac...
doi.org
December 26, 2025 at 6:20 AM
mol-biomed.bsky.social
#Research
#FOSL1-#PRMT1 transcriptional-epigenetic circuit promotes #glioblastoma radioresistance via calcyphosine-mediated DNA repair and invasion doi.org/10.1186/s435...

#CAPS #DNA #Damage #Repair #Radioresistance
FOSL1-PRMT1 transcriptional-epigenetic circuit promotes glioblastoma radioresistance via calcyphosine-mediated DNA repair and invasion - Molecular Biomedicine
Radioresistance constitutes a major therapeutic barrier in glioblastoma (GBM), frequently leading to tumor recurrence and poor clinical outcomes. Despite advances in multimodal therapies, the molecula...
doi.org
December 26, 2025 at 6:17 AM
mol-biomed.bsky.social
#Research
Peripheral TERT- positive #leukocytes as a #biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression doi.org/10.1186/s435...

#LungAdenocarcinoma #LUAD #Invasive #Adenocarcinoma #Immunosuppression
Peripheral TERT- positive leukocytes as a biomarker of the local and systemic immune failure in early-stage lung adenocarcinoma progression - Molecular Biomedicine
The prognosis of early-stage lung adenocarcinoma (LUAD) worsens significantly during the progression from adenocarcinoma in situ/minimally invasive adenocarcinoma (AIS/MIA) to invasive adenocarcinoma ...
doi.org
December 26, 2025 at 6:13 AM
mol-biomed.bsky.social
#Review
Tumor-associated macrophages in cancer: from mechanisms to application doi.org/10.1186/s435...

#TumorMicroenvironment #MacrophagePolarization #TargetedTherapy #PrognosticPrediction #ImmuneInfiltration
Tumor-associated macrophages in cancer: from mechanisms to application - Molecular Biomedicine
Tumor-associated macrophages (TAMs) are central constituents of the tumor microenvironment (TME), recruited from circulating monocytes through chemotactic signals, and they execute complex, multifacet...
doi.org
December 26, 2025 at 6:10 AM
mol-biomed.bsky.social
#Research
Atrial fibrillation: from pathogenesis to novel treatment options doi.org/10.1186/s435...

#AtrialFibrillation #AF #Pathogenesis #CryoballoonAblation #PulmonaryVeinIsolation #PVI #Pulsed_fieldAblation #PFA
Atrial fibrillation: from pathogenesis to novel treatment options - Molecular Biomedicine
The management of atrial fibrillation (AF) is currently undergoing a significant paradigm shift, driven by a deepening understanding of pathophysiology and the urgent need to overcome the inherent saf...
doi.org
December 26, 2025 at 6:07 AM
mol-biomed.bsky.social
#Article
Neutrophil Irg1/itaconate axis protects against experimental colitis by suppressing local inflammation and maintaining hematopoietic homeostasis doi.org/10.1186/s435...

#Irg1 #Itaconate #Neutrophil #InflammatoryBowelDisease #ExperimentalColitis #IBD
Neutrophil Irg1/itaconate axis protects against experimental colitis by suppressing local inflammation and maintaining hematopoietic homeostasis - Molecular Biomedicine
Inflammatory bowel disease (IBD) is a chronic, relapsing disorder characterized by excessive inflammation and often associated with extraintestinal symptoms. Current treatments remain unsatisfactory. ...
doi.org
December 26, 2025 at 6:00 AM
mol-biomed.bsky.social
#Research
#Pharmacological inhibition of Ubiquitin-Specific Peptidase 10 (#USP10) with spautin-1 attenuates adipogenesis through CCAAT/Enhancer-Binding Protein Beta (C/EBPβ) destabilization doi.org/10.1186/s435...

#Spautin_1 #Adipogenesis #LipidAccumulation #Deubiquitination
Pharmacological inhibition of Ubiquitin-Specific Peptidase 10 (USP10) with spautin-1 attenuates adipogenesis through CCAAT/Enhancer-Binding Protein Beta (C/EBPβ) destabilization - Molecular Biomedicin...
The pharmacological control of lipid accumulation in white adipose tissue (WAT) is a key area of focus in obesity research, yet the role of deubiquitination in adipocyte lipid storage remains underexp...
doi.org
December 26, 2025 at 5:56 AM
mol-biomed.bsky.social
#Research
Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in #ColorectalCancer doi.org/10.1186/s435...

#Myofibroblasts #ExtracellularMatrix #TNS1 #FERMT2
Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2–Fibronectin 1–Integrin signaling axis as a prognostic determinant in colorectal cancer - Molecular Biomedicine
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with its heterogeneous molecular profiles complicating prognosis prediction. Multi-omics profiling of clinical CR...
doi.org
December 19, 2025 at 5:59 AM
mol-biomed.bsky.social
#Research
Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera doi.org/10.1186/s435...

#RegulatoryTcells #CD47 #PD_L1 #Immunotherapy #TME #AptamersiRNAchimera
Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera - Molecular Biomedicine
Tumor-infiltrating regulatory T (Treg) cells contribute to immune evasion and are associated with poor prognosis in solid tumors. While CD47 blockade has demonstrated efficacy in hematologic malignanc...
doi.org
December 19, 2025 at 5:59 AM
mol-biomed.bsky.social
#Letter
Th-1 cytokine-primed small extracellular vesicles from limbal mesenchymal stem cells (#MSCs) modulate immune and inflammatory responses in Hashimoto's Thyroiditis (#HT): an ex vivo proof-of-concept study doi.org/10.1186/s435...
Th-1 cytokine-primed small extracellular vesicles from limbal mesenchymal stem cells modulate immune and inflammatory responses in Hashimoto's Thyroiditis: an ex vivo proof-of-concept study - Molecula...
Molecular Biomedicine -
doi.org
December 19, 2025 at 5:54 AM
mol-biomed.bsky.social
#Review
#Intratumoral #microbiome: a crucial regulating factor in development and progression of colorectal cancer doi.org/10.1186/s435...

#ColorectalCancer #TumorMicroenvironment #TME #ImmuneModulation #Biomarkers
Intratumoral microbiome: a crucial regulating factor in development and progression of colorectal cancer - Molecular Biomedicine
Colorectal cancer (CRC) is one of the most malignant cancers, and studies have indicated that microbes within tumors play a crucial role in CRC. Advanced methodologies, including single-cell and spati...
doi.org
December 19, 2025 at 5:43 AM
mol-biomed.bsky.social
#Research
Clinicopathological characteristics, genetic aberrations, and optimized treatment strategies in double-hit and triple-hit #lymphoma: a multi-center #CohortStudy
doi.org/10.1186/s435...

#THL #DHL #Double_hit #Triple_hit #GeneticCharacteristics #TargetedTherapy
Clinicopathological characteristics, genetic aberrations, and optimized treatment strategies in double-hit and triple-hit lymphoma: a multi-center cohort study - Molecular Biomedicine
High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements constitutes a distinct clinicopathological entity characterized by aggressive behavior, inherent resistance to conventional immu...
doi.org
December 19, 2025 at 5:40 AM
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#Review
Gastrointestinal cancer: molecular pathogenesis and targeted therapy doi.org/10.1186/s435...

#GastrointestinalTumor #Immunotherapy #TargetedTherapy #SignalTransduction
Gastrointestinal cancer: molecular pathogenesis and targeted therapy - Molecular Biomedicine
Gastrointestinal (GI) cancers pose a significant global health burden, driven by complex molecular alterations and microenvironmental interactions. Advances in molecular pathogenesis have elucidated r...
doi.org
December 19, 2025 at 5:37 AM
mol-biomed.bsky.social
#Review
#Single_cellSequencing and #organoids: applications in organ development and disease doi.org/10.1186/s435...

#Cancer #DiseaseModeling
Single-cell sequencing and organoids: applications in organ development and disease - Molecular Biomedicine
The integration of single-cell sequencing and organoid technologies has been transformative for biomedical research, enabling investigations of organ development, disease mechanisms, and therapeutic i...
doi.org
December 19, 2025 at 3:56 AM
mol-biomed.bsky.social
#Research
Down-regulation of #RBM47 due to diminished activation by forkhead box A1 ( #FOXA1) and silencing by #CpG methylation is associated with epithelial-mesenchymal transition ( #EMT) and #metastasis of #ColorectalCancer
doi.org/10.1186/s435...

#DNAmethylation
Down-regulation of RBM47 due to diminished activation by forkhead box A1 (FOXA1) and silencing by CpG methylation is associated with epithelial-mesenchymal transition and metastasis of colorectal canc...
The gene encoding the RNA-binding motif protein 47 (RBM47) is highly expressed in epithelial cells and its down-regulation is characteristic for many types of cancer, among them colorectal cancer (CRC...
doi.org
December 19, 2025 at 3:49 AM
mol-biomed.bsky.social
#Review
Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications doi.org/10.1186/s435...

#EpigeneticRegulation #DNAmethylation #HistoneModifications #TumorImmunity #ClinicalTranslation
Epigenetic drugs in cancer therapy: mechanisms, immune modulation, and therapeutic applications - Molecular Biomedicine
Epigenetic regulation is a fundamental mechanism controlling gene expression and cellular function, primarily mediated through reversible modifications such as DNA methylation, histone acetylation, an...
doi.org
December 12, 2025 at 9:21 AM
mol-biomed.bsky.social
#Review
Decoding the role of mesothelin in tumor dynamics and targeted treatment innovations doi.org/10.1186/s435...

#Mesothelin #TargetedTherapy #TumorMicroenvironment #TME #CAR_TCells #BispecificAntibodies
Decoding the role of mesothelin in tumor dynamics and targeted treatment innovations - Molecular Biomedicine
Mesothelin (MSLN) is among the most studied cancer-related antigens, and it is extensively studied as a therapeutic target for the treatment of various malignancies, including pleural mesothelioma, pa...
doi.org
December 12, 2025 at 9:16 AM
mol-biomed.bsky.social
#Review
Neutrophil Extracellular Traps (NETs) in health and disease doi.org/10.1186/s435...

#HealthyStates #InfectiousDisease #AutoimmuneDisease #CardiovascularDisease #Cancer
Neutrophil Extracellular Traps (NETs) in health and disease - Molecular Biomedicine
Neutrophil extracellular traps (NETs) are web-like structures composed of DNA, histones, and antimicrobial proteins that extend the defensive repertoire of neutrophils beyond classical phagocytosis an...
doi.org
December 12, 2025 at 9:06 AM
mol-biomed.bsky.social
#Research

Cholesterol induced-mitochondrial calcium dysregulation facilitates atherosclerosis by promoting lipid accumulation in vascular smooth muscle cells doi.org/10.1186/s435...

#Atherosclerosis #MitochondrialCalcium #MICU1 #inhibitor
Cholesterol induced-mitochondrial calcium dysregulation facilitates atherosclerosis by promoting lipid accumulation in vascular smooth muscle cells - Molecular Biomedicine
Mitochondria play an essential role in regulating various physiological functions including bioenergetics, calcium homeostasis, redox signaling, and lipid metabolism and also are involved in the patho...
doi.org
December 12, 2025 at 9:03 AM
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#Research
Delta-like ligand 4 mediated myeloid-derived suppressor cell metabolic reprogramming promotes neoadjuvant therapy resistance in titin-inactivated triple-negative breast cancer doi.org/10.1186/s435...

#TNBC #TTNinactivation #MDSCs #GlycolyticMetabolism #DLL4_MCT4
Delta-like ligand 4 mediated myeloid-derived suppressor cell metabolic reprogramming promotes neoadjuvant therapy resistance in titin-inactivated triple-negative breast cancer - Molecular Biomedicine
Triple-negative breast cancer (TNBC) is characterized by complex genomic background and treatment resistance. We first defined “Titin (TTN) inactivation”, a state of TTN expression deficiency or mutat...
doi.org
December 12, 2025 at 9:01 AM
mol-biomed.bsky.social
#Research
Identification of PIWI-interacting RNAs based models for lung adenocarcinoma early detection: a multicenter cohort study doi.org/10.1186/s435...

#LungAdenocarcinoma #LUAD #Piwi_interactingRNAs #EarlyDetection #NodulesStratification #MachineLearning
Identification of PIWI-interacting RNAs based models for lung adenocarcinoma early detection: a multicenter cohort study - Molecular Biomedicine
Early detection of lung adenocarcinoma (LUAD) remains a major clinical challenge despite the widespread application of low-dose computed tomography (LDCT). Circulating PIWI-interacting RNAs (piRNAs), ...
doi.org
December 12, 2025 at 8:57 AM
mol-biomed.bsky.social
#Research
Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells doi.org/10.1186/s435...

#BenignProstaticHyperplasia #Fibroblasts #Sunitinib #RTK #Signaling #CSF1R
Fibroblasts promote the progression of benign prostatic hyperplasia through colony-stimulating factor 1 receptor-mediated RTK signaling in prostatic epithelial cells - Molecular Biomedicine
Benign prostatic hyperplasia (BPH) is a prevalent condition characterized by nonmalignant proliferation of epithelial and stromal components in the prostate, frequently resulting in lower urinary trac...
doi.org
December 12, 2025 at 8:52 AM
mol-biomed.bsky.social
#Research
T-cell immunoglobulin and mucin domain-containing protein 3–mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne doi.org/10.1186/s435...

#SevereAcne #TIM3 #SingleCellTranscriptomics #Macrophages #Keratinocytes
T-cell immunoglobulin and mucin domain-containing protein 3–mediated immunomodulation in myeloid cells and keratinocytes in the development of severe acne - Molecular Biomedicine
Acne vulgaris is a common chronic inflammatory skin disorder with significant clinical and societal impacts. Severe acne (SA), in particular, causes scarring, disfigurement, and psychosocial distress....
doi.org
December 12, 2025 at 8:45 AM
mol-biomed.bsky.social
#Research
Sentrin‐specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis doi.org/10.1186/s435...

#SENP3 #KLF4 #SUMOylation #PhenotypicSwitching #Atherosclerosis
Sentrin‐specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis - Molecular Biomedicine
Phenotypic switching of vascular smooth muscle cells (VSMCs) from a contractile toward a synthetic phenotype plays a critical role in atherosclerosis. Although the redox-sensitive sentrin/Small Ubiqui...
doi.org
December 12, 2025 at 8:39 AM