I think that the waterfall is the subject of line 3, whereas Carney assumes that it is the “summer”, even though it not mentioned. Murphy changes linn “pool” to thoinn “wave”, which has the benefit of creating alliteration with té, but in the bigger picture linn té tánic lúachrae lúad...
/3
/3
May 13, 2025 at 5:23 AM
I think that the waterfall is the subject of line 3, whereas Carney assumes that it is the “summer”, even though it not mentioned. Murphy changes linn “pool” to thoinn “wave”, which has the benefit of creating alliteration with té, but in the bigger picture linn té tánic lúachrae lúad...
/3
/3
Low levels of the microRNA miR-1468-5p in lung adenocarcinoma (LUAD) patients link to lower survival rates. It plays a role in disease progression through various pathways, including HIF-1 signaling. This microRNA could be key in future LUAD treatments and serve as a predictor of patient outcomes.
Unveiling miR-1468-5p: A New Prognostic Biomarker and Therapeutic Target in Lung Adenocarcinoma.
Published in Recent patents on anti-cancer drug discovery
doi.org
February 4, 2025 at 2:00 PM
Low levels of the microRNA miR-1468-5p in lung adenocarcinoma (LUAD) patients link to lower survival rates. It plays a role in disease progression through various pathways, including HIF-1 signaling. This microRNA could be key in future LUAD treatments and serve as a predictor of patient outcomes.
🔴 ALERTE INFO ➡️ https://l.bfmtv.com/luaD
March 24, 2025 at 5:38 PM
🔴 ALERTE INFO ➡️ https://l.bfmtv.com/luaD
In vivo experiments confirmed ABCB7 knockdown suppressed tumor growth and increased ferroptosis sensitivity. These findings highlight the YY1-ABCB7 axis as a potential therapeutic target to disrupt LUAD progression and enhance ferroptosis-based treatments.
August 23, 2025 at 5:15 AM
In vivo experiments confirmed ABCB7 knockdown suppressed tumor growth and increased ferroptosis sensitivity. These findings highlight the YY1-ABCB7 axis as a potential therapeutic target to disrupt LUAD progression and enhance ferroptosis-based treatments.
It seems we're doing characters from the same universe
bsky.app/profile/luad...
bsky.app/profile/luad...
This is my first Halloween and for this occasion I'm dressing up like an overworked 30+ yo gamedev that hasn't slept in a bed in three months
October 31, 2025 at 7:54 PM
It seems we're doing characters from the same universe
bsky.app/profile/luad...
bsky.app/profile/luad...
Summarizing the differences in genomic features, driver genes & #epigenetic targets between #LUAD & LUSC, and the distinct strategies & protocols emerging in #chemotherapy, targeted therapy, & #immunotherapy for the clinical management of LUAD & LUSC. #medsky
#OpenAccess:
buff.ly/sph33Eu
#OpenAccess:
buff.ly/sph33Eu
June 12, 2025 at 1:18 AM
Summarizing the differences in genomic features, driver genes & #epigenetic targets between #LUAD & LUSC, and the distinct strategies & protocols emerging in #chemotherapy, targeted therapy, & #immunotherapy for the clinical management of LUAD & LUSC. #medsky
#OpenAccess:
buff.ly/sph33Eu
#OpenAccess:
buff.ly/sph33Eu
I want the doctor to be able to write "Lung Adenocarcinoma", "LUAD", "Lung AD" or something I haven't even thought of depending on their preference. I want my data to be a maximum pain to work with.
August 6, 2025 at 7:55 PM
I want the doctor to be able to write "Lung Adenocarcinoma", "LUAD", "Lung AD" or something I haven't even thought of depending on their preference. I want my data to be a maximum pain to work with.
This comprehensive study leveraged machine learning and gene co-expression analysis to identify three key biomarkers linked to DNA damage response and crotonylation in lung adenocarcinoma (LUAD).
November 7, 2025 at 3:40 PM
This comprehensive study leveraged machine learning and gene co-expression analysis to identify three key biomarkers linked to DNA damage response and crotonylation in lung adenocarcinoma (LUAD).
📰EGFR-TKI resistance in LUAD isn’t always genetic.
- 39 pts-derived organoids
- 50% resistant organoids had no know res mutations. A “basal-shift” phenotype drives res via NKX2-1 loss.
- Knockout of NKX2-1 → basal-shift + Osim res
- These tumors often lose CDKN2A/B
pbs.twimg.com/media/Gq6QwX...
- 39 pts-derived organoids
- 50% resistant organoids had no know res mutations. A “basal-shift” phenotype drives res via NKX2-1 loss.
- Knockout of NKX2-1 → basal-shift + Osim res
- These tumors often lose CDKN2A/B
pbs.twimg.com/media/Gq6QwX...
May 14, 2025 at 12:44 PM
📰EGFR-TKI resistance in LUAD isn’t always genetic.
- 39 pts-derived organoids
- 50% resistant organoids had no know res mutations. A “basal-shift” phenotype drives res via NKX2-1 loss.
- Knockout of NKX2-1 → basal-shift + Osim res
- These tumors often lose CDKN2A/B
pbs.twimg.com/media/Gq6QwX...
- 39 pts-derived organoids
- 50% resistant organoids had no know res mutations. A “basal-shift” phenotype drives res via NKX2-1 loss.
- Knockout of NKX2-1 → basal-shift + Osim res
- These tumors often lose CDKN2A/B
pbs.twimg.com/media/Gq6QwX...
These findings suggest that MRPL15 is a critical regulator of LUAD cell proliferation and could serve as a potential biomarker or therapeutic target for this deadly form of lung cancer.
August 18, 2025 at 11:38 AM
These findings suggest that MRPL15 is a critical regulator of LUAD cell proliferation and could serve as a potential biomarker or therapeutic target for this deadly form of lung cancer.
Dom-ḟarcai fidbaide fál
fom-chain loíd luin, lúad nād cél;
hūas mo lebrán, ind línech,
fom-chain trírech inna n-én.
Fomm-chain coí men, medair mass,
hi mbrot glass de dingnaib doss.
Debrath! nom-Choimmdiu-coíma:
caín-scríbaimm fo roída ross.
fom-chain loíd luin, lúad nād cél;
hūas mo lebrán, ind línech,
fom-chain trírech inna n-én.
Fomm-chain coí men, medair mass,
hi mbrot glass de dingnaib doss.
Debrath! nom-Choimmdiu-coíma:
caín-scríbaimm fo roída ross.
September 13, 2025 at 3:12 PM
Dom-ḟarcai fidbaide fál
fom-chain loíd luin, lúad nād cél;
hūas mo lebrán, ind línech,
fom-chain trírech inna n-én.
Fomm-chain coí men, medair mass,
hi mbrot glass de dingnaib doss.
Debrath! nom-Choimmdiu-coíma:
caín-scríbaimm fo roída ross.
fom-chain loíd luin, lúad nād cél;
hūas mo lebrán, ind línech,
fom-chain trírech inna n-én.
Fomm-chain coí men, medair mass,
hi mbrot glass de dingnaib doss.
Debrath! nom-Choimmdiu-coíma:
caín-scríbaimm fo roída ross.
Ní hea. Tá na focail sin ann le seacht siolla a chur sa líne, sin an méid: lúad nád cél = lua nach gceilfidh mé.
September 13, 2025 at 6:02 AM
Ní hea. Tá na focail sin ann le seacht siolla a chur sa líne, sin an méid: lúad nád cél = lua nach gceilfidh mé.
Tá na imreoirí óg de chuid Learpholl amach ar iasacht ach beidhsiad ar ais go luad
Learpholl: Tá an-chuid fós le teacht ó na leaids óga
Is iad Learpholl an fhoireann fearr an séasúr seo. I gcás cuid dá gcuid naimhde, níl le sin ach tréimhse ghearr ratha.
extrag.ie
February 7, 2025 at 7:34 AM
Tá na imreoirí óg de chuid Learpholl amach ar iasacht ach beidhsiad ar ais go luad
These findings suggest S1P could serve as a valuable biomarker for brain metastasis risk assessment and a potential therapeutic target in EGFR-mutant LUAD.
October 19, 2025 at 6:08 AM
These findings suggest S1P could serve as a valuable biomarker for brain metastasis risk assessment and a potential therapeutic target in EGFR-mutant LUAD.
Assessing Immune Microenvironment in TCGA-LUAD via CIBERSORTx Using Single-Cell Derived Signature Matrix and ESTIMATE Algorithm https://www.biorxiv.org/content/10.1101/2024.05.08.592760v1
Assessing Immune Microenvironment in TCGA-LUAD via CIBERSORTx Using Single-Cell Derived Signature Matrix and ESTIMATE Algorithm https://www.biorxiv.org/content/10.1101/2024.05.08.592760v1
Lung cancer (LC) remains a significant global health concern, affecting millions worldwide each year
www.biorxiv.org
May 11, 2024 at 1:48 AM
Assessing Immune Microenvironment in TCGA-LUAD via CIBERSORTx Using Single-Cell Derived Signature Matrix and ESTIMATE Algorithm https://www.biorxiv.org/content/10.1101/2024.05.08.592760v1
Jag har egen brunn.
Nice - blir kanske luad ål i helgen.
Nice - blir kanske luad ål i helgen.
January 16, 2025 at 8:15 PM
Jag har egen brunn.
Nice - blir kanske luad ål i helgen.
Nice - blir kanske luad ål i helgen.
New study (n=75 LUAD patients +in vitro/in vivo models) shows lactate-producing Staphylococcus in lung tumors can promote metastasis, with S. nepalensis & S. capitis driving tumor spread by activating MCT1–pseudohypoxia–NDRG1 signaling in tumor cells in mice.
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma
The role of the lung microbiota in cancer remains unclear. Here, we reveal that Staphylococcus is selectively enriched in metastatic tumor lesions and…
www.sciencedirect.com
July 16, 2025 at 11:56 AM
New study (n=75 LUAD patients +in vitro/in vivo models) shows lactate-producing Staphylococcus in lung tumors can promote metastasis, with S. nepalensis & S. capitis driving tumor spread by activating MCT1–pseudohypoxia–NDRG1 signaling in tumor cells in mice.
🔗 www.sciencedirect.com/science/arti...
🔗 www.sciencedirect.com/science/arti...
what a luad of expected shit talk from MTG 🖕
May 19, 2025 at 6:31 PM
what a luad of expected shit talk from MTG 🖕
The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights.
https://doi.org/10.3389/fimmu.2025.1582587
https://doi.org/10.3389/fimmu.2025.1582587
May 2, 2025 at 4:03 AM
The suppressive role of GLS in radiosensitivity and irradiation-induced immune response in LUAD: integrating bioinformatics and experimental insights.
https://doi.org/10.3389/fimmu.2025.1582587
https://doi.org/10.3389/fimmu.2025.1582587
4/ TCGA datasets
If you’re analyzing differential expression between LUAD (lung adenocarcinoma) and LUSC (lung squamous cell carcinoma):
• Both groups have hundreds of samples.
Instead of DESeq2, a Wilcoxon rank-sum test is faster and avoids FDR inflation.
If you’re analyzing differential expression between LUAD (lung adenocarcinoma) and LUSC (lung squamous cell carcinoma):
• Both groups have hundreds of samples.
Instead of DESeq2, a Wilcoxon rank-sum test is faster and avoids FDR inflation.
January 22, 2025 at 2:15 PM
4/ TCGA datasets
If you’re analyzing differential expression between LUAD (lung adenocarcinoma) and LUSC (lung squamous cell carcinoma):
• Both groups have hundreds of samples.
Instead of DESeq2, a Wilcoxon rank-sum test is faster and avoids FDR inflation.
If you’re analyzing differential expression between LUAD (lung adenocarcinoma) and LUSC (lung squamous cell carcinoma):
• Both groups have hundreds of samples.
Instead of DESeq2, a Wilcoxon rank-sum test is faster and avoids FDR inflation.
SCI leader Sylvia Plevritis & others propose a framework for comparing spatial features across samples. Their analysis of LUAD assembloids reveals tumor-stroma organization, drug-induced spatial changes, and insights into #DrugResistance. www.nature.com/articles/s41... #AI
March 12, 2025 at 4:00 PM
SCI leader Sylvia Plevritis & others propose a framework for comparing spatial features across samples. Their analysis of LUAD assembloids reveals tumor-stroma organization, drug-induced spatial changes, and insights into #DrugResistance. www.nature.com/articles/s41... #AI