Mohamed Ali, PhD
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mohamed-al.bsky.social
Mohamed Ali, PhD
@mohamed-al.bsky.social
Structural Biologist | Accelerating drug discovery
Obsessed with X ray-Crystallography and Cryo-EM
Sharing: Practical Structural Bio Tips
A beautiful protein crystal next to several salt crystals.

#crystallography #structuralbiology #crystal
March 2, 2025 at 6:56 PM
George Sheldrick (1942-2025): A Crystallographic Pioneer

In 2010, a single paper of George Sheldrick sent Acta Crystallographica A’s impact factor soaring from 2.05 to 54—surpassing Science and Nature. A true testament to his influence.

#Crystallography #SHELX #ScienceLegend
February 24, 2025 at 11:07 PM
George Sheldrick (1942-2025): A Crystallographic Pioneer

The world of crystallography has lost a legend. George Sheldrick’s #SHELX programs for structure determination, enabling countless discoveries.

#Crystallography #StructuralBiology #SHELX #ScienceLegend
February 24, 2025 at 11:07 PM
Nature’s Crystallization Experiment

As I looked out the window, I saw an ice sculpture, crafted by snow, wind, and temperature changes. It reminded me of protein crystallization:

→ Right conditions
→ Patience
→ Creativity

It's all about balance, whether in a lab or nature.

#Crystallization
February 18, 2025 at 2:12 AM
The Evolution of Structural Biology

1958: Decades of grinding calculations & whale meat to map myoglobin.
2024: AI predicts & designs proteins in seconds.
Enzymes 60,000x faster?
Plastic-eating nanorings?

#AI #ProteinDesign #StructuralBiology
February 17, 2025 at 6:21 AM
Are X-ray crystallography, cryo-EM, and NMR competitive or complementary?

Each has strengths and limitations—high resolution, flexibility, or dynamic insights. The future of structural biology lies in integration!

What’s your take?
#StructuralBiology #CryoEM #NMR #XrayCrystallography
February 16, 2025 at 7:25 PM
X-ray Crystallography 🆚 Cryo-EM 🆚 NMR

Are X-ray crystallography, Cryo-EM, and NMR competitive or complementary? 🤔

Think solving a puzzle—do you want sharp atomic details, a near-native image, or a dynamic view?

#StructuralBiology #XrayCrystallography #CryoEM #NMR
February 16, 2025 at 4:49 AM