Mohamed Ali, PhD
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Mohamed Ali, PhD
@mohamed-al.bsky.social
Structural Biologist | Accelerating drug discovery
Obsessed with X ray-Crystallography and Cryo-EM
Sharing: Practical Structural Bio Tips
A beautiful protein crystal next to several salt crystals.

#crystallography #structuralbiology #crystal
March 2, 2025 at 6:56 PM
A postdoctoral position at the Institute for Structural Biology

Using X-ray crystallography, Cryo-EM and NMR to study the structural assembly of MAPK signalling pathway complexes.

Link for details

www.jensen-nmr.fr?page_id=59
Join us > Malene R. Jensen @ IBS Grenoble
If you are interested in joining our team, please send CV and letter of motivation to Malene Ringkjøbing Jensen. We always welcome applications from master students, Ph.D. students and postdoctoral fe...
www.jensen-nmr.fr
February 26, 2025 at 12:30 PM
🚨 Postdoctoral opportunity 🚨

An exciting postdoctoral position in RNA-directed drug discovery.

Check the link for more information.

#RNASynthesis #DrugDiscovery #RNABiochemistry #StructurallBiology

t.co/VgkZD7dPsT
https://iit.taleo.net/careersection/ex/jobdetail.ftl?lang=it&job=25000017
t.co
February 26, 2025 at 5:44 AM
George Sheldrick (1942-2025): A Crystallographic Pioneer

In 2010, a single paper of George Sheldrick sent Acta Crystallographica A’s impact factor soaring from 2.05 to 54—surpassing Science and Nature. A true testament to his influence.

#Crystallography #SHELX #ScienceLegend
February 24, 2025 at 11:07 PM
George Sheldrick (1942-2025): A Crystallographic Pioneer

The world of crystallography has lost a legend. George Sheldrick’s #SHELX programs for structure determination, enabling countless discoveries.

#Crystallography #StructuralBiology #SHELX #ScienceLegend
February 24, 2025 at 11:07 PM
Nature’s Crystallization Experiment

As I looked out the window, I saw an ice sculpture, crafted by snow, wind, and temperature changes. It reminded me of protein crystallization:

→ Right conditions
→ Patience
→ Creativity

It's all about balance, whether in a lab or nature.

#Crystallization
February 18, 2025 at 2:12 AM
The Evolution of Structural Biology

1958: Decades of grinding calculations & whale meat to map myoglobin.
2024: AI predicts & designs proteins in seconds.
Enzymes 60,000x faster?
Plastic-eating nanorings?

#AI #ProteinDesign #StructuralBiology
February 17, 2025 at 6:21 AM
Are X-ray crystallography, cryo-EM, and NMR competitive or complementary?

Each has strengths and limitations—high resolution, flexibility, or dynamic insights. The future of structural biology lies in integration!

What’s your take?
#StructuralBiology #CryoEM #NMR #XrayCrystallography
February 16, 2025 at 7:25 PM
X-ray Crystallography 🆚 Cryo-EM 🆚 NMR

Are X-ray crystallography, Cryo-EM, and NMR competitive or complementary? 🤔

Think solving a puzzle—do you want sharp atomic details, a near-native image, or a dynamic view?

#StructuralBiology #XrayCrystallography #CryoEM #NMR
February 16, 2025 at 4:49 AM