Marco Lolaico
@mlolaico.bsky.social
Building nanoscale materials with DNA @ RUC, DK | Writing about AI-based protein design, DNA nanotech, molecular programming and more @ https://plentyofroom.beehiiv.com/
Such a cool work! And turning a weakness of DNA origami into a strength is super smart 😁🧪
Can you use DNA traps to fight tumors?
This new work uses DNA origami nanostructures to capture TGF𝛽1, a cytokine involved in tumor growth and immune suppression. The system reduces tumor size and increases survival in mice! 🧪🖥️🧬
Read the whole breakdown here 👉 tinyurl.com/ytz7e7fr
This new work uses DNA origami nanostructures to capture TGF𝛽1, a cytokine involved in tumor growth and immune suppression. The system reduces tumor size and increases survival in mice! 🧪🖥️🧬
Read the whole breakdown here 👉 tinyurl.com/ytz7e7fr
DNA Trash Cans: Outsmarting Tumor Signals with Origami Tech!
DNA origami creates innovative "tumor traps" that capture cancer-signaling molecules, offering a groundbreaking approach to targeting and neutralizing uncontrolled cellular growth.
plentyofroom.beehiiv.com
September 5, 2025 at 3:40 PM
Such a cool work! And turning a weakness of DNA origami into a strength is super smart 😁🧪
Cool work! Plastics from DNA? Funny idea 😎🧪
400 million tonnes of plastic are produced each year, with tons of environmental problems.
Can DNA-based plastic be the solution? Super cool work! 🧪🖥️🧬
PS read and subscribe here 👉 plentyofroom.beehiiv.com/p/dna-plasti...
Can DNA-based plastic be the solution? Super cool work! 🧪🖥️🧬
PS read and subscribe here 👉 plentyofroom.beehiiv.com/p/dna-plasti...
DNA Plastics: Recyclable, Biodegradable Revolution!
DNA and sugar chains create biodegradable, recyclable plastics, offering an innovative solution to global plastic pollution through groundbreaking molecular engineering.
plentyofroom.beehiiv.com
August 29, 2025 at 3:57 PM
Cool work! Plastics from DNA? Funny idea 😎🧪
Protein emulation with a silly name? Yes please 😎🧪
Emus and protein science?
Proteins are dynamic, but it's hard to study their transitions 🧪🖥️🧬
BioEmu uses machine learning to emulate protein dynamics with high precision and speed!
It complements simulations: first test with BioEmu, then continue with MD.
Read and subscribe tinyurl.com/enf5apzc
Proteins are dynamic, but it's hard to study their transitions 🧪🖥️🧬
BioEmu uses machine learning to emulate protein dynamics with high precision and speed!
It complements simulations: first test with BioEmu, then continue with MD.
Read and subscribe tinyurl.com/enf5apzc
AI-Powered Protein Dynamics: Decoding Hidden Molecular Movements!
AI-powered protein dynamics: Machine learning decodes hidden molecular movements, revealing complex protein behavior through innovative computational techniques.
plentyofroom.beehiiv.com
August 8, 2025 at 3:48 PM
Protein emulation with a silly name? Yes please 😎🧪
Don't miss this cool work! 🧪
New issue is here 🎉
Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable".
But today a new method creates binders using the power of computational methods! 🧪🖥️🧬
Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...
Some proteins like to fold in neat shapes, others enjoy chaos. Disordered proteins are considered "undruggable".
But today a new method creates binders using the power of computational methods! 🧪🖥️🧬
Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-designe...
AI-Designed Protein Targeting: Taming Disordered Protein Chaos!
AI-powered computational design unlocks disordered protein targets, transforming our understanding of flexible molecular structures and potential therapeutic approaches.
plentyofroom.beehiiv.com
July 27, 2025 at 8:01 AM
Don't miss this cool work! 🧪
Great work! 😎🧪
Do you want to save your data in DNA? Well, now is coming closer!
This amazing work from University of Washington and Microsoft explore how to use CRISPR-Cas9 to access data in DNA databases. Cool! 🧪🧬🖥️
Read the whole breakdown here 👉 plentyofroom.beehiiv.com/p/crispr-bas...
This amazing work from University of Washington and Microsoft explore how to use CRISPR-Cas9 to access data in DNA databases. Cool! 🧪🧬🖥️
Read the whole breakdown here 👉 plentyofroom.beehiiv.com/p/crispr-bas...
CRISPR-Based Data Storage: DNA Search Engine Revolution!
CRISPR-Cas9 breakthrough: Innovative DNA data storage and retrieval method uses genetic engineering to transform digital information archiving.
plentyofroom.beehiiv.com
July 21, 2025 at 3:35 PM
Great work! 😎🧪
The perfect article for your Sunday 😎🧪
Bacteria turning plastic into drugs? Oh yeah!
Sometimes bacteria aren't enough to solve problems. What about merging biocompatible chemistry and bacteria to turn plastic bottles into paracetamol? 🧪🖥️🧬
Want to get more like this? Just subscribe! 👉 plentyofroom.beehiiv.com/p/synbio-bre...
#chemistry
Sometimes bacteria aren't enough to solve problems. What about merging biocompatible chemistry and bacteria to turn plastic bottles into paracetamol? 🧪🖥️🧬
Want to get more like this? Just subscribe! 👉 plentyofroom.beehiiv.com/p/synbio-bre...
#chemistry
Synbio Breakthrough: Turning Plastic Bottles into Life-Saving Drugs!
Synthetic biology transforms plastic waste into life-saving drugs, showcasing innovative chemistry that turns environmental challenges into medical breakthroughs.
plentyofroom.beehiiv.com
July 13, 2025 at 2:29 PM
The perfect article for your Sunday 😎🧪
Don't miss this amazing work! 🧪
Finding new drugs is hard. Even more for macrocycles, the molecules that could be the new best thing in medicine!
🧪Enter RFpeptides, a machine learning pipeline for macrocycle binders! Great work from @uwproteindesign.bsky.social
Want more like this? 👉 tinyurl.com/2da2k8dy
#biotech #ML #AI 🧬🖥️
🧪Enter RFpeptides, a machine learning pipeline for macrocycle binders! Great work from @uwproteindesign.bsky.social
Want more like this? 👉 tinyurl.com/2da2k8dy
#biotech #ML #AI 🧬🖥️
AI Macrocycle Design: Revolutionizing Drug Discovery with Machine Learning!
AI-powered protein design creates macrocycles, leveraging machine learning to generate novel drug candidates and transform molecular engineering approaches.
plentyofroom.beehiiv.com
July 6, 2025 at 4:25 PM
Don't miss this amazing work! 🧪
Amazing work! 🧪
Nothing to read on Sunday? I got you covered!
What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪
Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML
#Ai
What about merging protein design and regenerative medicine? This paper brings computationally designed proteins to guide tissue regeneration! 🧪
Subscribe to get more like this 👉 tinyurl.com/423u2pss #biotech #ML
#Ai
Computational Protein Design: Regenerative Medicine's Healing Future!
Computational protein design revolutionizes regenerative medicine, engineering innovative biomaterials and scaffolds to guide tissue regeneration like sci-fi healing techniques.
tinyurl.com
June 29, 2025 at 2:43 PM
Amazing work! 🧪
Looking for some cool research? Don't miss this one then! 🧪
30% of proteins and 50% of target drugs are membrane proteins. And yet, their production is still hard! A great article from @ucdavis.bsky.social merges cell-free systems, robotics and machine learning to improve this!
Subscribe to get more like this 🧪🧬🖥️ #biotech #machinelearning #robotics
Subscribe to get more like this 🧪🧬🖥️ #biotech #machinelearning #robotics
Membrane Protein Synthesis: Robotics & ML Advancement!
Membrane protein production platform uses robotics and machine learning to revolutionize drug development, tackling challenges in synthesizing critical cellular proteins.
plentyofroom.beehiiv.com
June 6, 2025 at 8:17 AM
Looking for some cool research? Don't miss this one then! 🧪
Super cool work! 😎 🧪
Last week AI designed RNA, today it creates dynamic proteins! Small movements have a big impact in proteins, but it has been hard to replicate: until now! Great work from @ucsanfrancisco.bsky.social Subscribe to get more 👉 plentyofroom.beehiiv.com/p/ai-protein... 🧪🧬🖥️ #biotech #AI #deeplearning
AI Protein Switches: Designing Dynamic Multistate Molecular Machines!
AI-powered protein design creates dynamic, multistate protein switches that respond to mutations and ligands, increasing molecular engineering capabilities.
plentyofroom.beehiiv.com
May 30, 2025 at 8:15 AM
Super cool work! 😎 🧪
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Searching for a weekend read? I got you! Is it possible to leverage AI to create functional RNAs? Well, from now yes! 🧪 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech
AI RNA Design: Generating Functional Molecules with Machine Learning!
AI RNA design: Advanced machine learning techniques create functional RNA molecules, from CRISPR guides to innovative toehold switches.
plentyofroom.beehiiv.com
May 25, 2025 at 11:32 AM
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Are you looking for something to read? Here you go! AI has shown potential for protein design (looking at you, Alphafold). But is it possible to leverage it to create functional RNA? Well, from now yes! 🧪🖥️🧬 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech
AI RNA Design: Generating Functional Molecules with Machine Learning!
AI RNA design: Advanced machine learning techniques create functional RNA molecules, from CRISPR guides to innovative toehold switches.
plentyofroom.beehiiv.com
May 23, 2025 at 3:52 PM
Are you looking for something to read? Here you go! AI has shown potential for protein design (looking at you, Alphafold). But is it possible to leverage it to create functional RNA? Well, from now yes! 🧪🖥️🧬 Subscribe to get more like this 👉 plentyofroom.beehiiv.com/p/ai-rna-des... #AI #biotech
Looking for some weekend reading? 🧪
Did you miss this week's issue? Don't worry, you're still in time 😎 Today's paper mixes DNA origami with high-resolution microscopy to create nanopatterned functional surfaces! 🧪 Subscribe to get more like this! 👉 plentyofroom.beehiiv.com/p/nanoscale-... #DNA #nanotech #lithograpy #printing
DNA Origami Meets Lithography: Nanoscale Dog Printing
DNA origami meets lithography: Nanoscale patterning breakthrough creates precise DNA nanocrystals with intricate designs, including a playful dog print at nanometer resolution.
plentyofroom.beehiiv.com
May 18, 2025 at 10:23 AM
Looking for some weekend reading? 🧪
Amazing work bridging top-down and bottom-up nanofabrication! 🧪
Do you want to print microscale dogs with nanoscale features? Well, now you can! Today's paper mixes DNA origami with high-resolution microscopy to create nanopatterned functional surfaces! 🧪🖥️🧬 Subscribe to get more like this! 👉 plentyofroom.beehiiv.com #DNA #nanotech #lithograpy #printing
DNA Origami Meets Lithography: Nanoscale Dog Printing
DNA origami meets lithography: Nanoscale patterning breakthrough creates precise DNA nanocrystals with intricate designs, including a playful dog print at nanometer resolution.
plentyofroom.beehiiv.com
May 16, 2025 at 10:53 AM
Amazing work bridging top-down and bottom-up nanofabrication! 🧪
Should I get rid of my microscope? DNA microscopy lets you image your sample using only sequencing, now in 3D! 🧪 Super cool work from University of Chicago. Subscribe today! #DNA #biotech #imaging #microscopy
plentyofroom.beehiiv.com/p/dna-micros...
plentyofroom.beehiiv.com/p/dna-micros...
DNA Microscopy: Seeing by Sequencing Revolution!
DNA microscopy revolutionizes imaging: sequencing techniques create unprecedented 3D cellular visualization, transforming how we image biological samples.
plentyofroom.beehiiv.com
May 9, 2025 at 11:22 AM
Should I get rid of my microscope? DNA microscopy lets you image your sample using only sequencing, now in 3D! 🧪 Super cool work from University of Chicago. Subscribe today! #DNA #biotech #imaging #microscopy
plentyofroom.beehiiv.com/p/dna-micros...
plentyofroom.beehiiv.com/p/dna-micros...
Are you wondering if AI will steal your job? I don't know about that, but it can create new enzymes! 🧪 Subscribe to get more like this in your inbox! #science #AI
AI Enzyme Design: Powering Molecular Catalysis with Cutting-Edge AI!
AI revolutionizes enzyme design, using machine learning to create innovative biological catalysts for complex reactions and molecular engineering breakthroughs.
plentyofroom.beehiiv.com
May 8, 2025 at 4:54 AM
Amazing work! Had to learn a lot to cover this 😂😅🧪
New issue is here! 🎉🧪🧬🖥️ CRISPR delivery is a problem: ENVLPE solves it! Amazing work from @tum.de and @www.helmholtz-munich.de Read everything and subscribe at 👉 plentyofroom.beehiiv.com/p/crispr-del... #geneediting #biotech #CRISPR
CRISPR Delivery: ENVLPE Boosts Gene Editing Efficiency 4x!
CRISPR delivery breakthrough: ENVLPE platform revolutionizes gene editing with 4x improved efficiency, transforming cellular engineering and molecular medicine.
plentyofroom.beehiiv.com
May 2, 2025 at 3:23 PM
Amazing work! Had to learn a lot to cover this 😂😅🧪
Looking for something to read today? Maybe you're also traveling to a conference? Here you go then 😎🧪
New issue is out! 🎉 What if we could increase rapid test's sensitivity by 100x, without increasing the cost? How? Using DNA origami! 🧪🧬🖥️ Great work from @lmumuenchen.bsky.social and @tum.de Subscribe at 👉 plentyofroom.beehiiv.com/p/dna-origam... #diagnostics #biotech #DNA #DNAorigami
DNA Origami Boosts Rapid Test Sensitivity: Diagnostics Breakthrough!
DNA origami revolutionizes rapid testing: nanotech boosts diagnostic sensitivity 125x, transforming point-of-care and home testing technology.
plentyofroom.beehiiv.com
April 27, 2025 at 8:37 AM
Looking for something to read today? Maybe you're also traveling to a conference? Here you go then 😎🧪
Great paper! And I did my best to summarise it as well 🧪
New issue is out! 🎉 What if we could increase rapid test's sensitivity by 100x, without increasing the cost? How? Using DNA origami! 🧪🧬🖥️ Great work from @lmumuenchen.bsky.social and @tum.de Subscribe at 👉 plentyofroom.beehiiv.com/p/dna-origam... #diagnostics #biotech #DNA #DNAorigami
DNA Origami Boosts Rapid Test Sensitivity: Diagnostics Breakthrough!
DNA origami revolutionizes rapid testing: nanotech boosts diagnostic sensitivity 125x, transforming point-of-care and home testing technology.
plentyofroom.beehiiv.com
April 25, 2025 at 5:53 AM
Great paper! And I did my best to summarise it as well 🧪
Amazing science 🧪
Are you looking for some "productive" procrastination? I have the solution: just head here and read how to improve delivery of RNA therapeutics! 😎🧬🖥️🧪 And don't forget to subscribe of course! #science #drugdelivery #drugs #RNA
AI-Designed RNA Delivery: Nature-Inspired Nanoparticles Target Immune Cells!
Cutting-edge nanomedicine breakthrough: lipid nanoparticles revolutionize RNA drug delivery, targeting immune cells in bone marrow and spleen with precision.
plentyofroom.beehiiv.com
April 22, 2025 at 7:19 PM
Amazing science 🧪
Reposted by Marco Lolaico
April 21, 2025 at 9:49 AM
Amazing work out of my "neighbours" at @dtu.dk 😎🧪🧬🖥️
New issue today! 🎉 I covered a great article out of @dtu.dk and @instadeep.bsky.social: can AI accelerate peptide discovery? 😎🧪🖥️🧬 The answer is yes, thanks to InstaNovo! Read everything and subscribe at 👉 plentyofroom.beehiiv.com/p/ai-protein... #AI #machinelearning #biotech #proteinscience
AI Protein Sequencing Breakthrough: Decoding Peptides Faster!
AI-powered protein sequencing: Instanovo uses advanced machine learning to decipher peptide structures, revolutionizing proteomics and biomedical research.
plentyofroom.beehiiv.com
April 17, 2025 at 7:57 PM
Amazing work out of my "neighbours" at @dtu.dk 😎🧪🧬🖥️
Reposted by Marco Lolaico
Colossal squid filmed in ocean for the first time. 🧪 www.bbc.co.uk/news/article...
Colossal squid filmed by scientists for first time in ocean
Stunned scientists say the extremely rare squid can weigh up to 500kg (1,100lb).
www.bbc.co.uk
April 16, 2025 at 1:11 PM
Colossal squid filmed in ocean for the first time. 🧪 www.bbc.co.uk/news/article...
Why not put more DNA in your cells? 🧪🖥️🧬
Just in case you missed this paper: the authors created DNA receptors for artificial cells 😎🧬🖥️🧪 plentyofroom.beehiiv.com/p/programmab...
Programmable DNA Receptors: Nanotech Advances Cellular Signaling
DNA nanotechnology creates programmable cell receptors, enabling self-assembling molecular systems with signal detection and response capabilities.
plentyofroom.beehiiv.com
April 16, 2025 at 1:52 PM
Why not put more DNA in your cells? 🧪🖥️🧬
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We teamed up with our pals at @ucsandiego.bsky.social to show how jumbo #phages – huge viruses that prey on bacteria – use sneaky tricks to attack their victims! This knowledge could be used to leverage them as a tool to fight antibiotic resistance. Read more here: ow.ly/6VLa50Vucc5 🦠
April 15, 2025 at 4:30 AM
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