Maria Letizia Di Martino
@mldm.bsky.social
Senior Researcher at Uppsala University | Host-pathogen interactions | Intestinal organoids | Virulence gene regulation | Shigella and Salmonella | Functional genomics | Affiliated to the SellinLab @sellinlab.bsky.social
Huge congratulations to Thibault Frisch for leading this work to completion with remarkable insight and drive, and thanks to all co-authors for making it happen! @sellinlab.bsky.social, @lbarquist.bsky.social, @andrenmateus.bsky.social, @holmqvist-lab.bsky.social
June 17, 2025 at 9:39 AM
Huge congratulations to Thibault Frisch for leading this work to completion with remarkable insight and drive, and thanks to all co-authors for making it happen! @sellinlab.bsky.social, @lbarquist.bsky.social, @andrenmateus.bsky.social, @holmqvist-lab.bsky.social
pcnB (poly-A polymerase I) sustains replication of the Shigella virulence plasmid at levels optimal for virulence and boosts intraepithelial expansion in intestinal organoid monolayers.
June 17, 2025 at 9:36 AM
pcnB (poly-A polymerase I) sustains replication of the Shigella virulence plasmid at levels optimal for virulence and boosts intraepithelial expansion in intestinal organoid monolayers.
Thank you so much!
June 13, 2025 at 11:35 AM
Thank you so much!
Stay tuned for a follow up story coming out soon!
June 12, 2025 at 4:12 PM
Stay tuned for a follow up story coming out soon!
Finally thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for for highlighting our work with this cool editorial: www.nature.com/articles/s41...
Organoid models advance dysentery control - Nature Genetics
Shigella is a major human pathogen with a stark lack of pipelines linking genome content to clinical pathogenesis. An innovative study using large-scale organoid models, combined with genome-wide muta...
www.nature.com
June 12, 2025 at 3:56 PM
Finally thanks @sydneylmiles.bsky.social and @sergemostowylab.bsky.social for for highlighting our work with this cool editorial: www.nature.com/articles/s41...
Deeply grateful to @sellinlab.bsky.social for the unwavering support! And special thanks to our lab members Anjeela Bhetwal, @erixoneriksson.bsky.social, Ana Lopes, Angelika Ntokaki, and Martina Pasqua for their contributions. Also grateful to @andrenmateus.bsky.social and our clinical collaborators
June 12, 2025 at 3:54 PM
Deeply grateful to @sellinlab.bsky.social for the unwavering support! And special thanks to our lab members Anjeela Bhetwal, @erixoneriksson.bsky.social, Ana Lopes, Angelika Ntokaki, and Martina Pasqua for their contributions. Also grateful to @andrenmateus.bsky.social and our clinical collaborators
This study was co-led with our outstanding collaborators @lbarquist.bsky.social and Laura Jenniches — whose computational expertise was key to making this possible.
June 12, 2025 at 3:53 PM
This study was co-led with our outstanding collaborators @lbarquist.bsky.social and Laura Jenniches — whose computational expertise was key to making this possible.
One of the most exciting insights: Shigella uses tRNA-modifying enzymes and codon usage bias to fine-tune its virulence!
June 12, 2025 at 3:52 PM
One of the most exciting insights: Shigella uses tRNA-modifying enzymes and codon usage bias to fine-tune its virulence!