@mitulamehta.bsky.social
Reposted
The project is led by Oliver Howes at KCL, this job will be supervised by me, also @pgarner.bsky.social (who built the model) and @vaughanbell.bsky.social. Patient studies involve @mitulamehta.bsky.social, Kelly Diederen and others! 4/5
September 30, 2025 at 1:07 PM
The project is led by Oliver Howes at KCL, this job will be supervised by me, also @pgarner.bsky.social (who built the model) and @vaughanbell.bsky.social. Patient studies involve @mitulamehta.bsky.social, Kelly Diederen and others! 4/5
The full study is published today here: www.nature.com/articles/s41... :
Summary here:
www.kcl.ac.uk/news/ketamin...
and here: www.maudsleybrc.nihr.ac.uk/posts/2025/j...
Led by the excellent @lukejelenski.bsky.social 3/3
Summary here:
www.kcl.ac.uk/news/ketamin...
and here: www.maudsleybrc.nihr.ac.uk/posts/2025/j...
Led by the excellent @lukejelenski.bsky.social 3/3
Effect of naltrexone pretreatment on ketamine-induced glutamatergic activity and symptoms of depression: a randomized crossover study - Nature Medicine
The opioid system modulates ketamine’s effects in major depressive disorder, with naltrexone reducing acute glutamatergic activity and acute antidepressant effects.
www.nature.com
July 24, 2025 at 1:34 PM
The full study is published today here: www.nature.com/articles/s41... :
Summary here:
www.kcl.ac.uk/news/ketamin...
and here: www.maudsleybrc.nihr.ac.uk/posts/2025/j...
Led by the excellent @lukejelenski.bsky.social 3/3
Summary here:
www.kcl.ac.uk/news/ketamin...
and here: www.maudsleybrc.nihr.ac.uk/posts/2025/j...
Led by the excellent @lukejelenski.bsky.social 3/3
This mechanism could explain why the opiate antagonist reduces ketamine’s glutamate surge. The subsequent reduction in the antidepressant response suggests this glutamate mechanism is necessary. 2/3
July 24, 2025 at 1:32 PM
This mechanism could explain why the opiate antagonist reduces ketamine’s glutamate surge. The subsequent reduction in the antidepressant response suggests this glutamate mechanism is necessary. 2/3