🔋Mitochondria Mechanic🔬
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mitorandy.bsky.social
🔋Mitochondria Mechanic🔬
@mitorandy.bsky.social
𝙈𝙞𝙩𝙤𝙘𝙝𝙤𝙣𝙙𝙧𝙞𝙖 in health, cardiovascular disease, & aging. PhD in mitochondrial physiology. Posts are my own opinions.
Reposted by 🔋Mitochondria Mechanic🔬
Some more fun #mitochondria science for Friday, from Bioenergetics 4th edition by Nicholls & Ferguson. Mitochondrial charge, respiration, and oxidant production relationships: 🧪
February 2, 2024 at 8:14 PM
Reposted by 🔋Mitochondria Mechanic🔬
Excellent review on mitochondria and inflammation exploring how endosymbiosis may explain some things. 🧪

www.nature.com/articles/s41...
www.nature.com
February 8, 2024 at 12:39 AM
A mitochondrial origin for inherited diabetes mellitus 🧪

www.nature.com/articles/s41...
March 7, 2024 at 3:24 PM
Excellent review on mitochondria and inflammation exploring how endosymbiosis may explain some things. 🧪

www.nature.com/articles/s41...
www.nature.com
February 8, 2024 at 12:39 AM
Some more fun #mitochondria science for Friday, from Bioenergetics 4th edition by Nicholls & Ferguson. Mitochondrial charge, respiration, and oxidant production relationships: 🧪
February 2, 2024 at 8:14 PM
Reposted by 🔋Mitochondria Mechanic🔬
How do proteins get into mitochondria? Another graphic from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪
January 2, 2024 at 7:05 PM
How do proteins get into mitochondria? Another graphic from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪
January 2, 2024 at 7:05 PM
Reposted by 🔋Mitochondria Mechanic🔬
Studying mitochondria in isolation has revealed complex bioenergetic relationships that are useful for understanding physiology in general. More good stuff from Bioenergetics 4th edition by Nicholls & Ferguson 🧪
December 28, 2023 at 4:47 PM
"We breathe at the molecular level when mitochondria in our cells consume oxygen to extract energy from nutrients." Great first sentence of an abstract from this paper:

www.science.org/doi/10.1126/...
Multiple approaches of cellular metabolism define the bacterial ancestry of mitochondria
The aerobic ancestry of mitochondria is unveiled with multiple approaches.
www.science.org
December 29, 2023 at 4:05 PM
Reposted by 🔋Mitochondria Mechanic🔬
Hey. The fragmentation of the social media landscape has been hard on indie #scicomm 🧪 projects

So if you'd like to follow a podcast that's enthusiastic about #linguistics, could you check out @lingthusiasm.bsky.social?

And if you think your followers might like to, could you give this a repost?
December 28, 2023 at 5:43 PM
Studying mitochondria in isolation has revealed complex bioenergetic relationships that are useful for understanding physiology in general. More good stuff from Bioenergetics 4th edition by Nicholls & Ferguson 🧪
December 28, 2023 at 4:47 PM
Reposted by 🔋Mitochondria Mechanic🔬
Mitochondria are the powerhouse of the cell
Mitochondria move around in cells 🔋🏎️ Heres another nice diagram from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪
December 27, 2023 at 10:02 PM
Mitochondria move around in cells 🔋🏎️ Heres another nice diagram from Bioenergetics 4th edition by Nicholls & Ferguson: 🧪
December 27, 2023 at 7:30 PM
Reposted by 🔋Mitochondria Mechanic🔬
Mitochondria use an electro⚡chemical🧪 proton gradient. It's usually mostly electric potential, but different circumstances can increase the contribution of diffusion potential. A deep cut from Bioenergetics 4th edition by Nicholls & Ferguson 🔋
December 20, 2023 at 3:05 PM
Reposted by 🔋Mitochondria Mechanic🔬
December 16, 2023 at 12:04 PM
Mitochondria use an electro⚡chemical🧪 proton gradient. It's usually mostly electric potential, but different circumstances can increase the contribution of diffusion potential. A deep cut from Bioenergetics 4th edition by Nicholls & Ferguson 🔋
December 20, 2023 at 3:05 PM
Mitochondria are little circuits in our cells. 🔌⚡💡🔋 Helpful analogy for interpreting many bioenergetics experiments. Another great figure from Bioenergetics 4th edition by Nicholls & Ferguson. 🧪
December 13, 2023 at 5:21 PM
Lift some weights! 💪 It doesn't take too much to protect your heart 🫀 and health 🧪

New @American_Heart statement:

professional.heart.org/en/science-n...
Resistance Exercise Training in Individuals With and Without Cardiovascular Disease: 2023 Update
professional.heart.org
December 8, 2023 at 3:28 PM
Reposted by 🔋Mitochondria Mechanic🔬
"systemic immune and inflammatory responses may lead to more severe illness in some patients"
SARS-CoV-2 can damage mitochondrion in heart, other organs, study finds.

Would B12 help? B12 would help.
#helpmechangethefuture
CDC case# 1232781-B4W6H4

www.cidrap.umn.edu/covid-19/sar...
SARS-CoV-2 can damage mitochondrion in heart, other organs, study finds
www.cidrap.umn.edu
December 4, 2023 at 11:42 AM
What is human aging? We still don't really know, but our organs might predict healthy versus unhealthy aging. 🧪

www.nature.com/articles/s41...
Organ aging signatures in the plasma proteome track health and disease - Nature
Blood plasma protein data was combined with machine learning models for a simple method to determine differences in organ-specific aging; the study provides a basis for the prediction of diseases and ...
www.nature.com
December 6, 2023 at 6:23 PM
Mitochondria, inflammation, and cardiovascular disease each influence one another. Interesting read: 🧪

journals.physiology.org/doi/abs/10.1...
Cardiovascular Aging: Spotlight on Mitochondria | American Journal of Physiology-Heart and Circulato...
Mitochondria are cellular organelles critical for ATP production and are particularly relevant to cardiovascular diseases including heart failure, atherosclerosis, ischemia reperfusion injury, and car...
journals.physiology.org
December 5, 2023 at 5:43 PM
Replacing damaged mitochondria with new ones could be important for many human diseases; high-quality causal studies are needed to start translating this growing evidence. 🧪

www.nature.com/articles/s42...
Mitophagy in human health, ageing and disease - Nature Metabolism
This Review discusses the role of mitophagy in cellular and organismal health and disease, with a specific focus on human ageing and evidence obtained in clinical studies.
www.nature.com
November 30, 2023 at 8:00 PM
Reposted by 🔋Mitochondria Mechanic🔬
Mitochondrial power and cardiac aging:🔋🫀🧪 Great review article on one of my favorite broad topics:

www.ncbi.nlm.nih.gov/pmc/articles...
Mitochondrial proton leak in cardiac aging
Age-associated diseases are becoming progressively more prevalent, reflecting the increased lifespan of the world’s population. However, the fundamental mechanisms of physiologic aging are poorly un...
www.ncbi.nlm.nih.gov
November 26, 2023 at 6:44 PM
Reposted by 🔋Mitochondria Mechanic🔬
"Politicians don't understand science"

... say the key science advisers during an inquiry that was set up to investigate how prepared the United Kingdom was for the COVID-19 pandemic.

I say "duh!"
🧪

www.nature.com/articles/d41...
‘Politicians don’t understand science’: advisers give evidence at UK COVID inquiry
Patrick Vallance, Chris Witty and others reflect on advising the UK government during the ongoing investigation into the country’s pandemic response. Patrick Vallance, Chris Witty and others reflect...
www.nature.com
November 26, 2023 at 3:02 PM
Mitochondrial power and cardiac aging:🔋🫀🧪 Great review article on one of my favorite broad topics:

www.ncbi.nlm.nih.gov/pmc/articles...
Mitochondrial proton leak in cardiac aging
Age-associated diseases are becoming progressively more prevalent, reflecting the increased lifespan of the world’s population. However, the fundamental mechanisms of physiologic aging are poorly un...
www.ncbi.nlm.nih.gov
November 26, 2023 at 6:44 PM