@mitchell-lab.bsky.social
Regulation of transcription, stem cells, and trying to figure out the regulatory code. The Mitchell Lab at the U of Toronto.
Reposted
Come join us in person for an AI workshop watch party.
📢 Join Drs. Ma’n Zawati & James Tsui for a dynamic workshop on the ethics & impact of AI in scientific research.
📍 Attend in Montreal, UBC, or U of T — or join via Zoom!
🗓️ Free & in person with snacks 🍪
🔗 Register: www.eventbrite.com/e/harnessing...
#AI #Genomics #CEEHRC #ScienceEthics
📍 Attend in Montreal, UBC, or U of T — or join via Zoom!
🗓️ Free & in person with snacks 🍪
🔗 Register: www.eventbrite.com/e/harnessing...
#AI #Genomics #CEEHRC #ScienceEthics
September 10, 2025 at 11:46 AM
Come join us in person for an AI workshop watch party.
Reposted
The Department of Cell & Systems Biology at University of Toronto invites applications for a full-time tenure stream position in the field of Animal Morphogenesis.
#CellBiology #DevelopmentalBiology #mechanobiology #TissueMorphogenesis
#SystemsBiology
jobs.utoronto.ca/job/Toronto-...
#CellBiology #DevelopmentalBiology #mechanobiology #TissueMorphogenesis
#SystemsBiology
jobs.utoronto.ca/job/Toronto-...
Assistant Professor - Animal Morphogenesis
Assistant Professor - Animal Morphogenesis
jobs.utoronto.ca
September 19, 2025 at 9:21 PM
The Department of Cell & Systems Biology at University of Toronto invites applications for a full-time tenure stream position in the field of Animal Morphogenesis.
#CellBiology #DevelopmentalBiology #mechanobiology #TissueMorphogenesis
#SystemsBiology
jobs.utoronto.ca/job/Toronto-...
#CellBiology #DevelopmentalBiology #mechanobiology #TissueMorphogenesis
#SystemsBiology
jobs.utoronto.ca/job/Toronto-...
Reposted
CALL FOR ABSTRACTS!
The deadline for abstract submission (for talk consideration), early-bird rates, and travel award applications for the 2025 CEEHRC Annual Meeting is TODAY, FRIDAY, SEPTEMBER 19!
event.fourwaves.com/...
#epigenetics #ceehrc #epigenomes
1/2
The deadline for abstract submission (for talk consideration), early-bird rates, and travel award applications for the 2025 CEEHRC Annual Meeting is TODAY, FRIDAY, SEPTEMBER 19!
event.fourwaves.com/...
#epigenetics #ceehrc #epigenomes
1/2
CEEHRC 11th Annual Canadian Conference on Epigenetics
Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics
event.fourwaves.com
September 19, 2025 at 4:00 PM
CALL FOR ABSTRACTS!
The deadline for abstract submission (for talk consideration), early-bird rates, and travel award applications for the 2025 CEEHRC Annual Meeting is TODAY, FRIDAY, SEPTEMBER 19!
event.fourwaves.com/...
#epigenetics #ceehrc #epigenomes
1/2
The deadline for abstract submission (for talk consideration), early-bird rates, and travel award applications for the 2025 CEEHRC Annual Meeting is TODAY, FRIDAY, SEPTEMBER 19!
event.fourwaves.com/...
#epigenetics #ceehrc #epigenomes
1/2
Reposted
DEADLINE EXTENDED!
Early-bird registration, abstract submission for talk consideration, and travel award application deadline has been extended to FRIDAY, SEPTEMBER 19!
Abstracts submitted after Sep 19 will be included in poster sessions.
event.fourwaves.com/...
1/2
Early-bird registration, abstract submission for talk consideration, and travel award application deadline has been extended to FRIDAY, SEPTEMBER 19!
Abstracts submitted after Sep 19 will be included in poster sessions.
event.fourwaves.com/...
1/2
September 12, 2025 at 9:00 PM
DEADLINE EXTENDED!
Early-bird registration, abstract submission for talk consideration, and travel award application deadline has been extended to FRIDAY, SEPTEMBER 19!
Abstracts submitted after Sep 19 will be included in poster sessions.
event.fourwaves.com/...
1/2
Early-bird registration, abstract submission for talk consideration, and travel award application deadline has been extended to FRIDAY, SEPTEMBER 19!
Abstracts submitted after Sep 19 will be included in poster sessions.
event.fourwaves.com/...
1/2
Come join us in person for an AI workshop watch party.
📢 Join Drs. Ma’n Zawati & James Tsui for a dynamic workshop on the ethics & impact of AI in scientific research.
📍 Attend in Montreal, UBC, or U of T — or join via Zoom!
🗓️ Free & in person with snacks 🍪
🔗 Register: www.eventbrite.com/e/harnessing...
#AI #Genomics #CEEHRC #ScienceEthics
📍 Attend in Montreal, UBC, or U of T — or join via Zoom!
🗓️ Free & in person with snacks 🍪
🔗 Register: www.eventbrite.com/e/harnessing...
#AI #Genomics #CEEHRC #ScienceEthics
September 10, 2025 at 11:46 AM
Come join us in person for an AI workshop watch party.
Reposted
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
September 8, 2025 at 3:15 PM
🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...
Reposted
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
September 1, 2025 at 2:59 PM
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!
register here for the entire series: us06web.zoom.us/webinar/regi...
register here for the entire series: us06web.zoom.us/webinar/regi...
Our latest is online now, we discovered that enhancers cause surrounding chromatin to acquire euchromatin modifications and produce non-coding RNA making regions without enhancer activity look like enhancers. doi.org/10.1101/2025...
Enhancers mediate euchromatin hopping at chromatin contact points
Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...
doi.org
September 8, 2025 at 1:26 AM
Our latest is online now, we discovered that enhancers cause surrounding chromatin to acquire euchromatin modifications and produce non-coding RNA making regions without enhancer activity look like enhancers. doi.org/10.1101/2025...
Reposted
🧪🌱Plants started off as aquatic organisms. But how did they make the jump to land?
The Christendat lab show in @molbioevol.bsky.social that SKL1 is necessary for chloroplast formation and this function is conserved in land plants from liverworts to flowering plants!
www.utoronto.ca/news/researc...
The Christendat lab show in @molbioevol.bsky.social that SKL1 is necessary for chloroplast formation and this function is conserved in land plants from liverworts to flowering plants!
www.utoronto.ca/news/researc...
Researchers identify protein that evolved to enable plants to thrive on land
Evolutionary plant biologists at the University of Toronto have identified a protein that evolved approximately 500 million years ago that enables plants to convert light into energy through photosynt...
www.utoronto.ca
August 15, 2025 at 5:55 PM
🧪🌱Plants started off as aquatic organisms. But how did they make the jump to land?
The Christendat lab show in @molbioevol.bsky.social that SKL1 is necessary for chloroplast formation and this function is conserved in land plants from liverworts to flowering plants!
www.utoronto.ca/news/researc...
The Christendat lab show in @molbioevol.bsky.social that SKL1 is necessary for chloroplast formation and this function is conserved in land plants from liverworts to flowering plants!
www.utoronto.ca/news/researc...
Reposted
#DYK there is #SciArt on display around the CSB Buildings @utoronto.ca?
Keep your eyes open for gorgeous images created by our @uoftartsci.bsky.social students, from their research and as artwork
You can also view these images in our online gallery!
csb.utoronto.ca/research-ove...
Keep your eyes open for gorgeous images created by our @uoftartsci.bsky.social students, from their research and as artwork
You can also view these images in our online gallery!
csb.utoronto.ca/research-ove...
July 31, 2025 at 7:07 PM
#DYK there is #SciArt on display around the CSB Buildings @utoronto.ca?
Keep your eyes open for gorgeous images created by our @uoftartsci.bsky.social students, from their research and as artwork
You can also view these images in our online gallery!
csb.utoronto.ca/research-ove...
Keep your eyes open for gorgeous images created by our @uoftartsci.bsky.social students, from their research and as artwork
You can also view these images in our online gallery!
csb.utoronto.ca/research-ove...
Reposted
The CEEHRC Annual Meeting returns this fall!
Register NOW for the 11th Canadian Conference on Epigenetics taking place November 12-15, 2025 at the Banff Centre for Arts and Creativity in Banff, Alberta.
event.fourwaves.com/...
1/7
Register NOW for the 11th Canadian Conference on Epigenetics taking place November 12-15, 2025 at the Banff Centre for Arts and Creativity in Banff, Alberta.
event.fourwaves.com/...
1/7
CEEHRC 11th Annual Canadian Conference on Epigenetics
Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics
event.fourwaves.com
July 24, 2025 at 5:00 PM
The CEEHRC Annual Meeting returns this fall!
Register NOW for the 11th Canadian Conference on Epigenetics taking place November 12-15, 2025 at the Banff Centre for Arts and Creativity in Banff, Alberta.
event.fourwaves.com/...
1/7
Register NOW for the 11th Canadian Conference on Epigenetics taking place November 12-15, 2025 at the Banff Centre for Arts and Creativity in Banff, Alberta.
event.fourwaves.com/...
1/7
Our study of how the AP1 transcription factor JUND regulates gene expression during human pregnancy is out now in @PLOS Genetics can01.safelinks.protection.outlook.com?url=https%3A...
JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium
Author summary The muscular layer of the uterus, is responsible for the forceful contractions that deliver the baby at the end of pregnancy. During the majority of pregnancy this muscle is not able to...
can01.safelinks.protection.outlook.com
June 3, 2025 at 2:57 PM
Our study of how the AP1 transcription factor JUND regulates gene expression during human pregnancy is out now in @PLOS Genetics can01.safelinks.protection.outlook.com?url=https%3A...
It’s a pun-tastic research day @uoftcellsysbiol.bsky.social
May 1, 2025 at 4:17 PM
It’s a pun-tastic research day @uoftcellsysbiol.bsky.social
Reposted
CSB students from @uoftartsci.bsky.social networked with alumni during a recent Backpack to Briefcase speed mentorship reception with @uoftalumni.bsky.social. Check out the story for career tips and examples of potential career paths!
b2B speed networking event: connecting CSB students and alumni through shared experiences and snacks - Department of Cell & Systems Biology
CSB students networked with alumni during a recent speed mentorship reception. Along with specific career advice, students learned a few common themes for the modern job market
csb.utoronto.ca
April 17, 2025 at 7:43 PM
CSB students from @uoftartsci.bsky.social networked with alumni during a recent Backpack to Briefcase speed mentorship reception with @uoftalumni.bsky.social. Check out the story for career tips and examples of potential career paths!
Reposted
It's #WorldHealthDay
Since 2000, maternal deaths globally declined by 40%! 💙
BUT—progress is slowing, and aid funding cuts mean major threats to lifesaving maternity services in many parts of the world. ❌
Since 2000, maternal deaths globally declined by 40%! 💙
BUT—progress is slowing, and aid funding cuts mean major threats to lifesaving maternity services in many parts of the world. ❌
April 7, 2025 at 6:56 AM
It's #WorldHealthDay
Since 2000, maternal deaths globally declined by 40%! 💙
BUT—progress is slowing, and aid funding cuts mean major threats to lifesaving maternity services in many parts of the world. ❌
Since 2000, maternal deaths globally declined by 40%! 💙
BUT—progress is slowing, and aid funding cuts mean major threats to lifesaving maternity services in many parts of the world. ❌
Reposted
Melanie Woodin, an internationally recognized neuroscientist who studies the mechanisms underlying learning and memory in the brain, has been named #UofT’s 17th president. ➡️ uoft.me/uoftpres
March 26, 2025 at 2:14 PM
Melanie Woodin, an internationally recognized neuroscientist who studies the mechanisms underlying learning and memory in the brain, has been named #UofT’s 17th president. ➡️ uoft.me/uoftpres
Reposted
As you scroll through our skeets, you’ll see that women scientists are vital to discoveries made at CSB.
For International Day of Women & Girls in Science, we’ve highlighted some recent impressive accomplishments #IDWGS2025 #WomenInScience
csb.utoronto.ca/supporting-t...
For International Day of Women & Girls in Science, we’ve highlighted some recent impressive accomplishments #IDWGS2025 #WomenInScience
csb.utoronto.ca/supporting-t...
February 11, 2025 at 10:29 PM
As you scroll through our skeets, you’ll see that women scientists are vital to discoveries made at CSB.
For International Day of Women & Girls in Science, we’ve highlighted some recent impressive accomplishments #IDWGS2025 #WomenInScience
csb.utoronto.ca/supporting-t...
For International Day of Women & Girls in Science, we’ve highlighted some recent impressive accomplishments #IDWGS2025 #WomenInScience
csb.utoronto.ca/supporting-t...
Supporting the talented women scientists of CSB on IDWGS csb.utoronto.ca/supporting-t...
Supporting the Talented Women Scientists in CSB on IDWGS - Department of Cell & Systems Biology
We are proud to recognize the accomplishments of the women scientists in CSB on 2025's International Day of Women & Girls in Science and to offer our support all year long
csb.utoronto.ca
February 12, 2025 at 12:32 AM
Supporting the talented women scientists of CSB on IDWGS csb.utoronto.ca/supporting-t...
Our work on the enhancers regulating Sox2 in neural stem cells is published! This one has been a long time in the works. We found a cluster of downstream enhancers, including the more well studied SRR2, are required to maintain Sox2 expression and anterior neural identity.
doi.org/10.1093/g3jo...
doi.org/10.1093/g3jo...
A Sox2 Enhancer Cluster Regulates Region-Specific Neural Fates from Mouse Embryonic Stem Cells
Abstract. Sex-determining region Y box 2 (Sox2) is a critical transcription factor for embryogenesis and neural stem and progenitor cell (NSPC) maintenance
doi.org
January 30, 2025 at 1:32 AM
Our work on the enhancers regulating Sox2 in neural stem cells is published! This one has been a long time in the works. We found a cluster of downstream enhancers, including the more well studied SRR2, are required to maintain Sox2 expression and anterior neural identity.
doi.org/10.1093/g3jo...
doi.org/10.1093/g3jo...
Career achievement unlocked - two publications come out on the same day!
Great collaboration with Tom Sexton
doi.org/10.1126/scia...
And fantastic work by Tiegh Taylor and Mitchell lab colleagues
journals.plos.org/plosgenetics...
Great collaboration with Tom Sexton
doi.org/10.1126/scia...
And fantastic work by Tiegh Taylor and Mitchell lab colleagues
journals.plos.org/plosgenetics...
Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics
Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.
doi.org
December 14, 2024 at 5:33 PM
Career achievement unlocked - two publications come out on the same day!
Great collaboration with Tom Sexton
doi.org/10.1126/scia...
And fantastic work by Tiegh Taylor and Mitchell lab colleagues
journals.plos.org/plosgenetics...
Great collaboration with Tom Sexton
doi.org/10.1126/scia...
And fantastic work by Tiegh Taylor and Mitchell lab colleagues
journals.plos.org/plosgenetics...
Out now in @ScienceAdvances A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin
doi.org/10.1126/scia...
doi.org/10.1126/scia...
Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics
Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.
doi.org
December 14, 2024 at 5:29 PM
Out now in @ScienceAdvances A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin
doi.org/10.1126/scia...
doi.org/10.1126/scia...
The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells. How are 2 genes separately regulated even though they are fairly close to each other in the genome, we find a primary role for gene separation distance. journals.plos.org/plosgenetics...
The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells
Author summary Our study explores how two closely related genes, Lefty1 and Lefty2, are regulated independently despite their proximity in the genome. Both genes play important roles in stem cell main...
journals.plos.org
December 14, 2024 at 3:24 PM
The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells. How are 2 genes separately regulated even though they are fairly close to each other in the genome, we find a primary role for gene separation distance. journals.plos.org/plosgenetics...
Beautiful walk at #AsilomarChromatin this afternoon. Looking forward to the evening session.
December 14, 2024 at 1:52 AM
Beautiful walk at #AsilomarChromatin this afternoon. Looking forward to the evening session.
Reposted
Always been amazed how cells actually INTENTIONALLY cause double strand breaks. At @asilomarchroma last night, Cheyenne Sadeghi @FrockLab @Stanford showed evidence supporting that during #meiosis, #ATM kinase can suppress translocations after #SPO11 induces the meiotic double strand break.
December 13, 2024 at 4:15 PM
Reposted
Kicking off the 2024 @asilomarchromatin meeting with Maria Aristizabal Queen’s Univ drilling down on cancer-derived #histone mutations in budding yeast. Affect #genome integrity, transcription, and chromatin compaction! So cool that her first talk was THIS conference when she was an undergrad!
December 13, 2024 at 4:24 AM