Adam Hendricks
@mindonmotors.bsky.social
kinesins, dynein, microtubules, neurodegeneration
November 12, 2025 at 6:05 PM
Tau phosphorylation also relieves inhibition of lysosome transport by tau in neurons and alters the distribution of lysosomes in axons.
August 4, 2025 at 5:54 PM
Tau phosphorylation also relieves inhibition of lysosome transport by tau in neurons and alters the distribution of lysosomes in axons.
Cooperatively-bound tau inhibits kinesin-1 (KIF5B) motility, and inhibition is relieved by phosphorylation. In contrast, kinesin-3 (KIF1A) is strongly inhibited by both phosphoresistive and phosphomimetic tau.
August 4, 2025 at 5:50 PM
Cooperatively-bound tau inhibits kinesin-1 (KIF5B) motility, and inhibition is relieved by phosphorylation. In contrast, kinesin-3 (KIF1A) is strongly inhibited by both phosphoresistive and phosphomimetic tau.
Similarly, phosphorylation blocks the ability of tau to bind cooperatively in neurons
August 4, 2025 at 5:47 PM
Similarly, phosphorylation blocks the ability of tau to bind cooperatively in neurons