Mikel Lavilla-Puerta
@mikellavi.bsky.social
Oxygen, yeast, SynBio and sometimes, plants. Postdoc at Oxford Biology, PhD at Scuola Superiore Sant'Anna.
I also sing and am very fond of my village.
I also sing and am very fond of my village.
Big thanks to everyone involved! @yuminghe.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social et al.!
Several years in the making and a lot of people met, but finally out as a preprint!
Several years in the making and a lot of people met, but finally out as a preprint!
September 5, 2025 at 4:32 PM
Big thanks to everyone involved! @yuminghe.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social et al.!
Several years in the making and a lot of people met, but finally out as a preprint!
Several years in the making and a lot of people met, but finally out as a preprint!
3] The role of hypoxia-inducible PCOs: why make more of an enzyme in hypoxia, where it has negligible activity..? Well, they actually do something! And they may be the key to engineer faster hypoxic responses
September 5, 2025 at 4:32 PM
3] The role of hypoxia-inducible PCOs: why make more of an enzyme in hypoxia, where it has negligible activity..? Well, they actually do something! And they may be the key to engineer faster hypoxic responses
Thanks to this yeast system we understood:
1] The Cys-NDP is responsible for these responses in plants happening in only 5-10min.
2] HRPE elements (in hypoxic promoters) compete for ERFVII TFs when these are limited. The more HRPEs, the faster the response!
1] The Cys-NDP is responsible for these responses in plants happening in only 5-10min.
2] HRPE elements (in hypoxic promoters) compete for ERFVII TFs when these are limited. The more HRPEs, the faster the response!
September 5, 2025 at 4:32 PM
Thanks to this yeast system we understood:
1] The Cys-NDP is responsible for these responses in plants happening in only 5-10min.
2] HRPE elements (in hypoxic promoters) compete for ERFVII TFs when these are limited. The more HRPEs, the faster the response!
1] The Cys-NDP is responsible for these responses in plants happening in only 5-10min.
2] HRPE elements (in hypoxic promoters) compete for ERFVII TFs when these are limited. The more HRPEs, the faster the response!
The Cys N-Degron Pathway (which controls plant responses to hypoxia) works in coordination with many, many other processes that finely tune low O2 responses.
We took it.
Put it in yeast, where no such regulation exists.
And it still works! So the Cys-NDP is self-sufficient...
We took it.
Put it in yeast, where no such regulation exists.
And it still works! So the Cys-NDP is self-sufficient...
September 5, 2025 at 4:32 PM
The Cys N-Degron Pathway (which controls plant responses to hypoxia) works in coordination with many, many other processes that finely tune low O2 responses.
We took it.
Put it in yeast, where no such regulation exists.
And it still works! So the Cys-NDP is self-sufficient...
We took it.
Put it in yeast, where no such regulation exists.
And it still works! So the Cys-NDP is self-sufficient...