Mikel Lavilla-Puerta
@mikellavi.bsky.social
Oxygen, yeast, SynBio and sometimes, plants. Postdoc at Oxford Biology, PhD at Scuola Superiore Sant'Anna.
I also sing and am very fond of my village.
I also sing and am very fond of my village.
Pinned
a cartoon of spongebob wearing a hat with the letter f on it
ALT: a cartoon of spongebob wearing a hat with the letter f on it
media.tenor.com
Preprint alert! 🗞
We used SynBio to "simplify" the plant oxygen sensing pathway and implement it in yeast🍄.
We can now control yeast growth through oxygen!
But most importantly,
Here's a very short recap of what we understood thanks to it:
biorxiv.org/content/10.110…
We used SynBio to "simplify" the plant oxygen sensing pathway and implement it in yeast🍄.
We can now control yeast growth through oxygen!
But most importantly,
Here's a very short recap of what we understood thanks to it:
biorxiv.org/content/10.110…
Reposted by Mikel Lavilla-Puerta
#ThrowbackThursday to last week Thursday at #ISPLORE2025JP where we took a group picture of our fantastic community. Missing those conferences vibes? Scroll back through the #ISPLORE2025JP hashtag for some of the best moments 🌱🌊
October 1, 2025 at 10:32 PM
#ThrowbackThursday to last week Thursday at #ISPLORE2025JP where we took a group picture of our fantastic community. Missing those conferences vibes? Scroll back through the #ISPLORE2025JP hashtag for some of the best moments 🌱🌊
Reposted by Mikel Lavilla-Puerta
#ISPLORE2025JP is over.. but not before a comedy performance and closing ceremony by the organizers Mikio Nakazono and Moto Ashikari 😆
Thanks so much to all organisers and sponsors for making this edition possible. It was truly amazing!
Next edition reveal by @djgibbs.bsky.social: #ISPLORE2028UK
Thanks so much to all organisers and sponsors for making this edition possible. It was truly amazing!
Next edition reveal by @djgibbs.bsky.social: #ISPLORE2028UK
September 26, 2025 at 5:08 AM
#ISPLORE2025JP is over.. but not before a comedy performance and closing ceremony by the organizers Mikio Nakazono and Moto Ashikari 😆
Thanks so much to all organisers and sponsors for making this edition possible. It was truly amazing!
Next edition reveal by @djgibbs.bsky.social: #ISPLORE2028UK
Thanks so much to all organisers and sponsors for making this edition possible. It was truly amazing!
Next edition reveal by @djgibbs.bsky.social: #ISPLORE2028UK
Reposted by Mikel Lavilla-Puerta
Coming to you live from #ISPLORE2025JP Fresh preprint from my lab showing that leaves progressively oxygenate and how this is important for their morphogenesis.Thanks to our collaborators from @Fra_LicO2si lab. #plantscience
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 22, 2025 at 6:47 AM
Coming to you live from #ISPLORE2025JP Fresh preprint from my lab showing that leaves progressively oxygenate and how this is important for their morphogenesis.Thanks to our collaborators from @Fra_LicO2si lab. #plantscience
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mikel Lavilla-Puerta
We finish this #ISPLORE2025JP session with exceptional talks by @mikellavi.bsky.social, Daai Zhang, @vinayshukla.bsky.social and Lina Zhou 🌱🌊 Check out @beagiuntoli.bsky.social's recent preprint #plantscience
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 23, 2025 at 8:57 AM
We finish this #ISPLORE2025JP session with exceptional talks by @mikellavi.bsky.social, Daai Zhang, @vinayshukla.bsky.social and Lina Zhou 🌱🌊 Check out @beagiuntoli.bsky.social's recent preprint #plantscience
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Mikel Lavilla-Puerta
The speed of hypoxia: great talk by @mikellavi.bsky.social at the @isplore.bsky.social conference in Nagoya!
September 23, 2025 at 7:33 AM
The speed of hypoxia: great talk by @mikellavi.bsky.social at the @isplore.bsky.social conference in Nagoya!
Reposted by Mikel Lavilla-Puerta
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants
Plants face hypoxic conditions either chronically, as particular tissues are characterized by fluctuating or stable low oxygen levels, or acutely, when flooded. In vascular plants, transcriptional ada...
www.biorxiv.org
September 8, 2025 at 10:15 AM
A synthetic ERFVII-dependent circuit in yeast sheds light on the regulation of early hypoxic responses of plants | Preprint from @mikellavi.bsky.social @beagiuntoli.bsky.social @syno2xis.bsky.social #N-degron #hypoxia www.biorxiv.org/content/10.1...
Preprint alert! 🗞
We used SynBio to "simplify" the plant oxygen sensing pathway and implement it in yeast🍄.
We can now control yeast growth through oxygen!
But most importantly,
Here's a very short recap of what we understood thanks to it:
biorxiv.org/content/10.110…
We used SynBio to "simplify" the plant oxygen sensing pathway and implement it in yeast🍄.
We can now control yeast growth through oxygen!
But most importantly,
Here's a very short recap of what we understood thanks to it:
biorxiv.org/content/10.110…
a cartoon of spongebob wearing a hat with the letter f on it
ALT: a cartoon of spongebob wearing a hat with the letter f on it
media.tenor.com
September 5, 2025 at 4:32 PM
Preprint alert! 🗞
We used SynBio to "simplify" the plant oxygen sensing pathway and implement it in yeast🍄.
We can now control yeast growth through oxygen!
But most importantly,
Here's a very short recap of what we understood thanks to it:
biorxiv.org/content/10.110…
We used SynBio to "simplify" the plant oxygen sensing pathway and implement it in yeast🍄.
We can now control yeast growth through oxygen!
But most importantly,
Here's a very short recap of what we understood thanks to it:
biorxiv.org/content/10.110…
Reposted by Mikel Lavilla-Puerta
“I come from a rural area where agriculture and natural spaces coexist.” academic.oup.com/plphys/artic...
#WeAreASPB
#WeAreASPB
August 1, 2025 at 5:15 PM
“I come from a rural area where agriculture and natural spaces coexist.” academic.oup.com/plphys/artic...
#WeAreASPB
#WeAreASPB
Reposted by Mikel Lavilla-Puerta
Honoured & excited that ‘Breathing Underground’ has been funded by the ERC!
This will let me explore one of the most fundamental questions of plant life: how roots breathe underground? @erc.europa.eu
This will let me explore one of the most fundamental questions of plant life: how roots breathe underground? @erc.europa.eu
September 4, 2025 at 2:48 PM
Honoured & excited that ‘Breathing Underground’ has been funded by the ERC!
This will let me explore one of the most fundamental questions of plant life: how roots breathe underground? @erc.europa.eu
This will let me explore one of the most fundamental questions of plant life: how roots breathe underground? @erc.europa.eu
Reposted by Mikel Lavilla-Puerta
The January 2025 issue of Plant Physiology is now online! Read this Focus Issue on Hypoxia and Plants here: https://academic.oup.com/plphys/issue @ASPB @OxUniPress #PlantSci
The diverse aspects of hypoxia. The size of the oxygen bubble correlates with concentration. This collection highlights the importance of hypoxia for plant development and environmental adaptation such as during flooding, in compacted or poorly aerated soils, high altitudes, and within meristematic tissues. Image credit: Moe Abbas.
academic.oup.com
January 2, 2025 at 6:16 PM
The January 2025 issue of Plant Physiology is now online! Read this Focus Issue on Hypoxia and Plants here: https://academic.oup.com/plphys/issue @ASPB @OxUniPress #PlantSci
The real deal on the topic of plant hypoxia, SynBio and orthogonality. How to use these three concepts to build new oxygen-sensitive circuits? Don't miss the thread below!
Preprint alert, please share!!
With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
December 16, 2024 at 9:11 AM
The real deal on the topic of plant hypoxia, SynBio and orthogonality. How to use these three concepts to build new oxygen-sensitive circuits? Don't miss the thread below!
Reposted by Mikel Lavilla-Puerta
Preprint alert, please share!!
With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
December 15, 2024 at 5:46 PM
Preprint alert, please share!!
With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
With our new study, we engineered an orthogonal hypoxia-responsive system in plants inspired by mammalian HIF protein degradation. We demonstrated that this system could control protein stability and activity, enabling modulation of Oxygen sensing outputs. Here's how:
Reposted by Mikel Lavilla-Puerta
Added many more ISPLORE researchers to our starter pack, including @theplantlab.bsky.social, @mikellavi.bsky.social @freddietheodoulou.bsky.social, @gunjansharma88.bsky.social. Welcome to BlueSky!
December 13, 2024 at 10:51 AM
Added many more ISPLORE researchers to our starter pack, including @theplantlab.bsky.social, @mikellavi.bsky.social @freddietheodoulou.bsky.social, @gunjansharma88.bsky.social. Welcome to BlueSky!
First Bluesky post to share our review with the world! Is there anything, beyond oxygen biosensors, that SynBio can provide to the world of plant hypoxia? Check it out here! @plantphys.bsky.social academic.oup.com/plphys/advan...
Designed to breathe: synthetic biology applications in plant hypoxia
Novel biosensors and concepts from engineering biology expand the toolbox for plant low oxygen biology research
academic.oup.com
December 5, 2024 at 8:51 PM
First Bluesky post to share our review with the world! Is there anything, beyond oxygen biosensors, that SynBio can provide to the world of plant hypoxia? Check it out here! @plantphys.bsky.social academic.oup.com/plphys/advan...