MIke Ambler
@mike-ambler.bsky.social
Wellcome Trust Early (!) Career Fellow
Consultant senior lecturer in intensive care
Hibernation
Consultant senior lecturer in intensive care
Hibernation
Pinned
MIke Ambler
@mike-ambler.bsky.social
· Mar 19
Synthetic torpor in the rat recapitulates key features of natural torpor and is cardioprotective
During hibernation, animals enter torpor, a reversible physiological state typically characterised by reductions in core temperature, heart rate and oxygen consumption. Species that enter this hypothe...
www.biorxiv.org
Very excited to post this preprint... making a species that doesn't hibernate do something a lot like it, AND showing it is cardioprotective.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by MIke Ambler
New research shows that people in Malawi admitted to hospital with breathlessness are much more likely to die within a year than other patients.
Read more: lstm.ac/4n4gC8i
Read more: lstm.ac/4n4gC8i
Breathlessness increases long-term mortality risk, Malawi study finds
Research led by Liverpool School of Tropical Medicine and the Malawi-Liverpool-Wellcome Programme shows that over half of hospital patients with breathlessness had died within a year of admission
lstm.ac
September 11, 2025 at 9:00 AM
New research shows that people in Malawi admitted to hospital with breathlessness are much more likely to die within a year than other patients.
Read more: lstm.ac/4n4gC8i
Read more: lstm.ac/4n4gC8i
Reposted by MIke Ambler
🧵1/15 Delighted to share our study on the naked mole-rat (NMR): a mammal with bizarre thermal biology, notorious longevity, and cancer resistance. But how do NMRs maintain (or fail to maintain) their body temperature? Our latest work digs deep! #ThermalBiology #Thermogenesis
July 28, 2025 at 2:23 PM
🧵1/15 Delighted to share our study on the naked mole-rat (NMR): a mammal with bizarre thermal biology, notorious longevity, and cancer resistance. But how do NMRs maintain (or fail to maintain) their body temperature? Our latest work digs deep! #ThermalBiology #Thermogenesis
Reposted by MIke Ambler
The speed of light visualized on a cosmic scale.
Credit: Dr James O'Donoghue
Credit: Dr James O'Donoghue
May 4, 2025 at 12:57 AM
The speed of light visualized on a cosmic scale.
Credit: Dr James O'Donoghue
Credit: Dr James O'Donoghue
Reposted by MIke Ambler
Reposted by MIke Ambler
I have never seen a situation so dismal that Tony Blair couldn't make it worse.
April 29, 2025 at 2:42 PM
I have never seen a situation so dismal that Tony Blair couldn't make it worse.
Reposted by MIke Ambler
This trial demonstrated the dangers of algorithmic adaptive trial design. Miscoding meant that pts were put into the wrong arms. The authors say that despite the trial not having internal validity it should be regarded as having validity outside of how it was conducted. I am not convinced. #EMIMCC
April 22, 2025 at 3:21 PM
This trial demonstrated the dangers of algorithmic adaptive trial design. Miscoding meant that pts were put into the wrong arms. The authors say that despite the trial not having internal validity it should be regarded as having validity outside of how it was conducted. I am not convinced. #EMIMCC
Reposted by MIke Ambler
Circle up
April 15, 2025 at 1:58 AM
Circle up
Reposted by MIke Ambler
The reason we were all watching the Challenger launch is because it was quite literally an assignment for us to do so.
Can't help but contrast this to today's flight. Back in the day, space flight was for science and learning (and yes, industry). Now? It's vanity.
www.nasa.gov/history/40-y...
Can't help but contrast this to today's flight. Back in the day, space flight was for science and learning (and yes, industry). Now? It's vanity.
www.nasa.gov/history/40-y...
40 Years Ago: President Reagan Announces Teacher in Space Project - NASA
On Aug. 27, 1984, President Ronald W. Reagan announced the Teacher in Space project as part of NASA’s Space Flight Participant Program to expand the space
www.nasa.gov
April 14, 2025 at 5:55 PM
The reason we were all watching the Challenger launch is because it was quite literally an assignment for us to do so.
Can't help but contrast this to today's flight. Back in the day, space flight was for science and learning (and yes, industry). Now? It's vanity.
www.nasa.gov/history/40-y...
Can't help but contrast this to today's flight. Back in the day, space flight was for science and learning (and yes, industry). Now? It's vanity.
www.nasa.gov/history/40-y...
Reposted by MIke Ambler
"On October 8, 1931, a law went into effect requiring every Italian university professor to sign an oath pledging their loyalty to the government of Benito Mussolini. Out of over 1,200 professors in the country, only 12 refused. All of them were immediately fired." www.chronicle.com/article/what...
Opinion | What Autocrats Want From Academics: Servility
In 1931, Italian scholars were made to take loyalty oaths. Will that happen to us?
www.chronicle.com
March 21, 2025 at 10:45 PM
"On October 8, 1931, a law went into effect requiring every Italian university professor to sign an oath pledging their loyalty to the government of Benito Mussolini. Out of over 1,200 professors in the country, only 12 refused. All of them were immediately fired." www.chronicle.com/article/what...
Very excited to post this preprint... making a species that doesn't hibernate do something a lot like it, AND showing it is cardioprotective.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Synthetic torpor in the rat recapitulates key features of natural torpor and is cardioprotective
During hibernation, animals enter torpor, a reversible physiological state typically characterised by reductions in core temperature, heart rate and oxygen consumption. Species that enter this hypothe...
www.biorxiv.org
March 19, 2025 at 12:55 PM
Very excited to post this preprint... making a species that doesn't hibernate do something a lot like it, AND showing it is cardioprotective.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...