Mikael Palner
@mikaelpalner.bsky.social
Researcher: The biological cause of mental illnesses, the pharmacological and neurobiological effects of treatments, including psychedelic drugs in both high and microdoses.
All posts are my own view and not a medical advice.
All posts are my own view and not a medical advice.
I love my new office hallway mates, DEI 💪
February 24, 2025 at 1:32 PM
I love my new office hallway mates, DEI 💪
Visited @jameswjesso.bsky.social **Adventures Through The Mind** podcast to talk about microdosing, psilocybin and translation of psychedelic science from rats to humans.
#microdosing #psilocybin
#microdosing #psilocybin
February 17, 2025 at 8:33 PM
Visited @jameswjesso.bsky.social **Adventures Through The Mind** podcast to talk about microdosing, psilocybin and translation of psychedelic science from rats to humans.
#microdosing #psilocybin
#microdosing #psilocybin
With president Trump hitting hard on science in the US, I want to let all my fellow US researchers know that Danish foundation provides quite a lot of postdoctoral and sabattical funding for visiting US citizens.
Reach out if you want to know more or collaborate while this goes down.
Reach out if you want to know more or collaborate while this goes down.
January 23, 2025 at 2:35 PM
With president Trump hitting hard on science in the US, I want to let all my fellow US researchers know that Danish foundation provides quite a lot of postdoctoral and sabattical funding for visiting US citizens.
Reach out if you want to know more or collaborate while this goes down.
Reach out if you want to know more or collaborate while this goes down.
Are you thinking of measuring synaptic plasticity in the living rat brain? Maybe after psychedelic-induced neuroplasticity, as David E Olson suggests in his recent commentary in the American Journal of Psychiatry
Check out our SV2A images using [18F]SynVest-1
#psychedelic #neuroplasticity #invivo
Check out our SV2A images using [18F]SynVest-1
#psychedelic #neuroplasticity #invivo
January 12, 2025 at 4:35 PM
Are you thinking of measuring synaptic plasticity in the living rat brain? Maybe after psychedelic-induced neuroplasticity, as David E Olson suggests in his recent commentary in the American Journal of Psychiatry
Check out our SV2A images using [18F]SynVest-1
#psychedelic #neuroplasticity #invivo
Check out our SV2A images using [18F]SynVest-1
#psychedelic #neuroplasticity #invivo
Do serotonergic psychedelics (like LSD, psilocybin, and 2C-B) all induce the same acute changes in brain activity? Our research in rats says they have some common features but also some distinctly different ones. The images below are from our newest preprint.
December 15, 2024 at 8:56 PM
Do serotonergic psychedelics (like LSD, psilocybin, and 2C-B) all induce the same acute changes in brain activity? Our research in rats says they have some common features but also some distinctly different ones. The images below are from our newest preprint.
Klemens Egger analyzed the effects of pharmahuasca on whole-brain metabolism in rats. Interestingly, while the combination of harmine and DMT increased the levels of DMT in the brain significantly, we could measure 5-HT2A occupancy. Additionally, all conditions increased thalamic activity. #dmt
December 11, 2024 at 6:59 AM
Klemens Egger analyzed the effects of pharmahuasca on whole-brain metabolism in rats. Interestingly, while the combination of harmine and DMT increased the levels of DMT in the brain significantly, we could measure 5-HT2A occupancy. Additionally, all conditions increased thalamic activity. #dmt
Last year, we used 5-HT2A PET (see my previous post) to establish science-backed psilocybin microdosing in rats based on human occupancy data from Madsen et al. (2019). We proved that microdosing of psilocybin induces behavioral and neurobiological changes in rats! www.nature.com/articles/s41...
November 28, 2024 at 2:26 PM
Last year, we used 5-HT2A PET (see my previous post) to establish science-backed psilocybin microdosing in rats based on human occupancy data from Madsen et al. (2019). We proved that microdosing of psilocybin induces behavioral and neurobiological changes in rats! www.nature.com/articles/s41...
Moving to a new lab is fantastic. 🐀 Reconnecting the cables, installing the machines and taking photos through a plastic bag is challenging 🤔
November 25, 2024 at 8:56 AM
Moving to a new lab is fantastic. 🐀 Reconnecting the cables, installing the machines and taking photos through a plastic bag is challenging 🤔
In 2008, Matthias Herth produced [18F]MHMZ, a PET tracer I love. My lab uses it extensively to map the 5-HT2A receptors in living rat brain and measure occupancy of psychedelics, like psilocybin below. Don't tell me 1mg/kg is not enough ;)
November 23, 2024 at 5:00 PM
In 2008, Matthias Herth produced [18F]MHMZ, a PET tracer I love. My lab uses it extensively to map the 5-HT2A receptors in living rat brain and measure occupancy of psychedelics, like psilocybin below. Don't tell me 1mg/kg is not enough ;)