Mikael Palner
@mikaelpalner.bsky.social
Researcher: The biological cause of mental illnesses, the pharmacological and neurobiological effects of treatments, including psychedelic drugs in both high and microdoses.
All posts are my own view and not a medical advice.
All posts are my own view and not a medical advice.
Was interviewed by Double Blind Magazine about the mushrooms extend lifespan hype.
They wrote a delightful piece about how much mushroom was given.
To quote them "That’s a fuckton of mushrooms for 95% of people".
I wonder about how the last 5% are doing?
doubleblindmag.com/was-the-life...
They wrote a delightful piece about how much mushroom was given.
To quote them "That’s a fuckton of mushrooms for 95% of people".
I wonder about how the last 5% are doing?
doubleblindmag.com/was-the-life...
Was the Life-Extending Psilocybin Study All Hype?
One academic says yes. PLUS an interview with an Onanya, AI generated DMT visuals, and psilocybin's impact on shame.
doubleblindmag.com
September 21, 2025 at 7:26 PM
Was interviewed by Double Blind Magazine about the mushrooms extend lifespan hype.
They wrote a delightful piece about how much mushroom was given.
To quote them "That’s a fuckton of mushrooms for 95% of people".
I wonder about how the last 5% are doing?
doubleblindmag.com/was-the-life...
They wrote a delightful piece about how much mushroom was given.
To quote them "That’s a fuckton of mushrooms for 95% of people".
I wonder about how the last 5% are doing?
doubleblindmag.com/was-the-life...
Psilocybin as an longevity drug? Not really!
I wrote a piece in @theconversation.com about why this claim is way out of proportions.
theconversation.com/why-the-magi...
I wrote a piece in @theconversation.com about why this claim is way out of proportions.
theconversation.com/why-the-magi...
Why the magic mushroom anti-ageing claims are overblown
The magic mushroom longevity study that’s too good to be true.
theconversation.com
August 28, 2025 at 12:31 PM
Psilocybin as an longevity drug? Not really!
I wrote a piece in @theconversation.com about why this claim is way out of proportions.
theconversation.com/why-the-magi...
I wrote a piece in @theconversation.com about why this claim is way out of proportions.
theconversation.com/why-the-magi...
Reposted by Mikael Palner
What shifts in our brain when our consciousness shifts? On Sept 8-9, we will explore this question at ESI-SyNC 2025 - with exciting talks, posters and discussions on the neural dynamics of altered consciousness, from psychedelics to breathwork, near-death experiences and meditation.
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July 31, 2025 at 4:42 PM
What shifts in our brain when our consciousness shifts? On Sept 8-9, we will explore this question at ESI-SyNC 2025 - with exciting talks, posters and discussions on the neural dynamics of altered consciousness, from psychedelics to breathwork, near-death experiences and meditation.
(1/2)
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Reposted by Mikael Palner
We worked so well as a team for the #GRCPsychedelics @vyazovskiy.bsky.social @viditavaidya.bsky.social @melissaherman.bsky.social
and congrats to @theborislab.bsky.social and @mikaelpalner.bsky.social, who will be the future vice-chairs!
and congrats to @theborislab.bsky.social and @mikaelpalner.bsky.social, who will be the future vice-chairs!
July 17, 2025 at 1:09 PM
We worked so well as a team for the #GRCPsychedelics @vyazovskiy.bsky.social @viditavaidya.bsky.social @melissaherman.bsky.social
and congrats to @theborislab.bsky.social and @mikaelpalner.bsky.social, who will be the future vice-chairs!
and congrats to @theborislab.bsky.social and @mikaelpalner.bsky.social, who will be the future vice-chairs!
Reposted by Mikael Palner
Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪
July 16, 2025 at 11:37 PM
Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪
Reposted by Mikael Palner
One more clip from my interview with @mikaelpalner.bsky.social.
In this one, he outlines a neurological definition for a psychedelic "microdose" according to binding occupancy at the serotonin receptor.
And, of course, what that means.
youtu.be/gG3JmDo_liU
In this one, he outlines a neurological definition for a psychedelic "microdose" according to binding occupancy at the serotonin receptor.
And, of course, what that means.
youtu.be/gG3JmDo_liU
A neural level definition of psychedelic microdosing, with Dr. Mikael Palner
YouTube video by Adventures Through The Mind
youtu.be
February 26, 2025 at 6:37 PM
One more clip from my interview with @mikaelpalner.bsky.social.
In this one, he outlines a neurological definition for a psychedelic "microdose" according to binding occupancy at the serotonin receptor.
And, of course, what that means.
youtu.be/gG3JmDo_liU
In this one, he outlines a neurological definition for a psychedelic "microdose" according to binding occupancy at the serotonin receptor.
And, of course, what that means.
youtu.be/gG3JmDo_liU
Reposted by Mikael Palner
Microdosing research is being polluted by a lack of specificity, says Dr. @mikaelpalner.bsky.social
youtu.be/0MZy1eLQUxY
youtu.be/0MZy1eLQUxY
Modern Microdosing Science has a Problem; All Psychedelics Aren't Created Equal - Dr. Mikael Palner
YouTube video by Adventures Through The Mind
youtu.be
February 25, 2025 at 8:24 PM
Microdosing research is being polluted by a lack of specificity, says Dr. @mikaelpalner.bsky.social
youtu.be/0MZy1eLQUxY
youtu.be/0MZy1eLQUxY
I love my new office hallway mates, DEI 💪
February 24, 2025 at 1:32 PM
I love my new office hallway mates, DEI 💪
Reposted by Mikael Palner
@mikaelpalner.bsky.social and I debate the value of removing the psychedelic effect from psychedelic drugs.
youtu.be/Qokk8MGkeHY
youtu.be/Qokk8MGkeHY
Debating the value of removing the psychedelic effect from psychedelic medicine, Dr. Mikael Palner
YouTube video by Adventures Through The Mind
youtu.be
February 22, 2025 at 1:07 PM
@mikaelpalner.bsky.social and I debate the value of removing the psychedelic effect from psychedelic drugs.
youtu.be/Qokk8MGkeHY
youtu.be/Qokk8MGkeHY
Reposted by Mikael Palner
"The very fact that I am having to publish this anonymously in a country that has the right to free speech written into our Constitution is an indictment of what is happening."
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Anger, despair, and defiance from a voice within the US federal research system
People around the world are watching with disbelief as the new US government closes down its aid programme, withdraws from the World Health Organization (WHO) and the Paris agreement on climate change...
www.bmj.com
February 17, 2025 at 4:33 AM
"The very fact that I am having to publish this anonymously in a country that has the right to free speech written into our Constitution is an indictment of what is happening."
www.bmj.com/content/388/...
www.bmj.com/content/388/...
Visited @jameswjesso.bsky.social **Adventures Through The Mind** podcast to talk about microdosing, psilocybin and translation of psychedelic science from rats to humans.
#microdosing #psilocybin
#microdosing #psilocybin
February 17, 2025 at 8:33 PM
Visited @jameswjesso.bsky.social **Adventures Through The Mind** podcast to talk about microdosing, psilocybin and translation of psychedelic science from rats to humans.
#microdosing #psilocybin
#microdosing #psilocybin
Reposted by Mikael Palner
I talk with Dr. Mikael Palner from Southern Denmark University about his research on the effects of chronic low dose (microdose) psilocybin on stress resiliency and compulsive behaviours.
www.jameswjesso.com/microdosing-...
#psychedelics #microdosing #psychedelicscience
www.jameswjesso.com/microdosing-...
#psychedelics #microdosing #psychedelicscience
Microdosing Psilocybin; Effects on Stress Resiliency and Compulsive Behaviours | Dr. Mikael Palner ~ ATTMind 194
Dr. Mikael Palner discusses his research on the effects of microdosing psilocybin on stress resiliency and compulsions.
www.jameswjesso.com
February 14, 2025 at 3:17 PM
I talk with Dr. Mikael Palner from Southern Denmark University about his research on the effects of chronic low dose (microdose) psilocybin on stress resiliency and compulsive behaviours.
www.jameswjesso.com/microdosing-...
#psychedelics #microdosing #psychedelicscience
www.jameswjesso.com/microdosing-...
#psychedelics #microdosing #psychedelicscience
@lizs1.bsky.social I'm happy to comment, I did a scientific study above on microdosing psilocybin in rat. www.nature.com/articles/s41...
Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats - Molecular Psychiatry
Molecular Psychiatry - Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats
www.nature.com
January 27, 2025 at 12:46 AM
@lizs1.bsky.social I'm happy to comment, I did a scientific study above on microdosing psilocybin in rat. www.nature.com/articles/s41...
With president Trump hitting hard on science in the US, I want to let all my fellow US researchers know that Danish foundation provides quite a lot of postdoctoral and sabattical funding for visiting US citizens.
Reach out if you want to know more or collaborate while this goes down.
Reach out if you want to know more or collaborate while this goes down.
January 23, 2025 at 2:35 PM
With president Trump hitting hard on science in the US, I want to let all my fellow US researchers know that Danish foundation provides quite a lot of postdoctoral and sabattical funding for visiting US citizens.
Reach out if you want to know more or collaborate while this goes down.
Reach out if you want to know more or collaborate while this goes down.
Are you thinking of measuring synaptic plasticity in the living rat brain? Maybe after psychedelic-induced neuroplasticity, as David E Olson suggests in his recent commentary in the American Journal of Psychiatry
Check out our SV2A images using [18F]SynVest-1
#psychedelic #neuroplasticity #invivo
Check out our SV2A images using [18F]SynVest-1
#psychedelic #neuroplasticity #invivo
January 12, 2025 at 4:35 PM
Are you thinking of measuring synaptic plasticity in the living rat brain? Maybe after psychedelic-induced neuroplasticity, as David E Olson suggests in his recent commentary in the American Journal of Psychiatry
Check out our SV2A images using [18F]SynVest-1
#psychedelic #neuroplasticity #invivo
Check out our SV2A images using [18F]SynVest-1
#psychedelic #neuroplasticity #invivo
This is a great review of novel measurements of functional connectivity.
But how would you explain "structurally informed functional connectivity" to a lay person?
Give me your best shot 😀
www.nature.com/articles/s41...
But how would you explain "structurally informed functional connectivity" to a lay person?
Give me your best shot 😀
www.nature.com/articles/s41...
Structurally informed models of directed brain connectivity - Nature Reviews Neuroscience
The influence anatomy exerts on communication between brain regions remains unclear. In this Review, Greaves et al. synthesize how methods of structural connectivity integration constrain inference-ba...
www.nature.com
January 6, 2025 at 4:44 PM
This is a great review of novel measurements of functional connectivity.
But how would you explain "structurally informed functional connectivity" to a lay person?
Give me your best shot 😀
www.nature.com/articles/s41...
But how would you explain "structurally informed functional connectivity" to a lay person?
Give me your best shot 😀
www.nature.com/articles/s41...
Reposted by Mikael Palner
A #ScienceReview from last year highlights the growing recognition of the complex cognitive capacities of #rats and its implications for how they are treated in scientific contexts.
The complex affective and cognitive capacities of rats
For several decades, although studies of rat physiology and behavior have abounded, research on rat emotions has been limited in scope to fear, anxiety, and pain. Converging evidence for the capacity of many species to share others' affective states has...
scim.ag
January 1, 2025 at 3:07 PM
A #ScienceReview from last year highlights the growing recognition of the complex cognitive capacities of #rats and its implications for how they are treated in scientific contexts.
Do serotonergic psychedelics (like LSD, psilocybin, and 2C-B) all induce the same acute changes in brain activity? Our research in rats says they have some common features but also some distinctly different ones. The images below are from our newest preprint.
December 15, 2024 at 8:56 PM
Do serotonergic psychedelics (like LSD, psilocybin, and 2C-B) all induce the same acute changes in brain activity? Our research in rats says they have some common features but also some distinctly different ones. The images below are from our newest preprint.
Klemens Egger analyzed the effects of pharmahuasca on whole-brain metabolism in rats. Interestingly, while the combination of harmine and DMT increased the levels of DMT in the brain significantly, we could measure 5-HT2A occupancy. Additionally, all conditions increased thalamic activity. #dmt
December 11, 2024 at 6:59 AM
Klemens Egger analyzed the effects of pharmahuasca on whole-brain metabolism in rats. Interestingly, while the combination of harmine and DMT increased the levels of DMT in the brain significantly, we could measure 5-HT2A occupancy. Additionally, all conditions increased thalamic activity. #dmt
Last year, we used 5-HT2A PET (see my previous post) to establish science-backed psilocybin microdosing in rats based on human occupancy data from Madsen et al. (2019). We proved that microdosing of psilocybin induces behavioral and neurobiological changes in rats! www.nature.com/articles/s41...
November 28, 2024 at 2:26 PM
Last year, we used 5-HT2A PET (see my previous post) to establish science-backed psilocybin microdosing in rats based on human occupancy data from Madsen et al. (2019). We proved that microdosing of psilocybin induces behavioral and neurobiological changes in rats! www.nature.com/articles/s41...
Moving to a new lab is fantastic. 🐀 Reconnecting the cables, installing the machines and taking photos through a plastic bag is challenging 🤔
November 25, 2024 at 8:56 AM
Moving to a new lab is fantastic. 🐀 Reconnecting the cables, installing the machines and taking photos through a plastic bag is challenging 🤔
In 2008, Matthias Herth produced [18F]MHMZ, a PET tracer I love. My lab uses it extensively to map the 5-HT2A receptors in living rat brain and measure occupancy of psychedelics, like psilocybin below. Don't tell me 1mg/kg is not enough ;)
November 23, 2024 at 5:00 PM
In 2008, Matthias Herth produced [18F]MHMZ, a PET tracer I love. My lab uses it extensively to map the 5-HT2A receptors in living rat brain and measure occupancy of psychedelics, like psilocybin below. Don't tell me 1mg/kg is not enough ;)
How will the world look in 25 years if my research turns out to be a breakthrough?
That question was posed to me by Third Ear Studio and Denis Rivin 🔹🔺🔸. In their latest series "2049". We're talking about mental illnesses and psychedelic substances.
thirdear.studio/da/pods/2049
That question was posed to me by Third Ear Studio and Denis Rivin 🔹🔺🔸. In their latest series "2049". We're talking about mental illnesses and psychedelic substances.
thirdear.studio/da/pods/2049
2049 | Third Ear Studio
thirdear.studio
November 22, 2024 at 6:15 PM
How will the world look in 25 years if my research turns out to be a breakthrough?
That question was posed to me by Third Ear Studio and Denis Rivin 🔹🔺🔸. In their latest series "2049". We're talking about mental illnesses and psychedelic substances.
thirdear.studio/da/pods/2049
That question was posed to me by Third Ear Studio and Denis Rivin 🔹🔺🔸. In their latest series "2049". We're talking about mental illnesses and psychedelic substances.
thirdear.studio/da/pods/2049